<![CDATA[NAD+ Buffered vs non-Buffered]]>Currently on a 5-on/2-off protocol of SS-31 4mg/day + MOTS-C 2mg/day. Honestly, I may have a marginal energy boost from this although it's a little tough to tell at the moment as I am also in my 7th week of a Reta cycle and the calorie deficit has my ass dragging. Introduced the SS-31 and MOTS-C around week 4 and the lethargy is about 70% gone so maybe this is an indicaiton that the MOTS-C/SS-31 are doing something.

From many of these threads, I see that when people add NAD+ (in sufficient amounts) to a protocol like this, typically, a clean energy surge kicks into gear. So I'm going ot give it a try. I could use a surge!!!

My question is around the NAD+ buffered vs non-buffered. My understanding is NAD+ is inherently acidic. Buffer can bring the ph up to a ~6 which makes these 100mg injections a bit more tollerable.

Some sites sell only buffered, some sell only non-buffered. Does anybody have any experience using both and do you see any significant differences in effecacy or administration?

Context:
50 yo
Male
Current Pins: Reta (wk 7), GHK-cu (just started), BP157, MOTS-C, SS-31
5'11"
155 lbs
Dexa = 9.5% body fat

]]>https://community.peptidecritic.com/topic/1009/nad-buffered-vs-non-bufferedRSS for NodeThu, 23 Apr 2026 13:24:25 GMTThu, 09 Apr 2026 14:39:32 GMT60<![CDATA[Reply to NAD+ Buffered vs non-Buffered on Sun, 12 Apr 2026 16:26:56 GMT]]>@ResearchCat This is exactly where I'm at...

]]>https://community.peptidecritic.com/post/3580https://community.peptidecritic.com/post/3580Sun, 12 Apr 2026 16:26:56 GMT<![CDATA[Reply to NAD+ Buffered vs non-Buffered on Sun, 12 Apr 2026 16:25:47 GMT]]>@justalittleprick

I hadn’t thought of that, but I think it’s a great alternative strategy. I should have done something like this from the get-go.

I originally posted because I’m considering adding NAD+ to boost my energy. I’m about to pull the trigger on an Ipamorelin, CJC-1295, and Tesamorelin stack and hit the gym hard, so I’ll definitely need the extra fuel. I’m also planning to start tapering off Retatrutide; while my sub-Q fat has diminished significantly, I still have some visceral fat I’d like to target.

I’m approaching the fine-tuning phase now, so I need to put away the bazooka and pull out the sniper rifle. My goal isn’t to hit 6–8% body fat, as I believe maintaining that level of leanness comes with a whole host of other issues (IMHO).

Thanks for the insight!

]]>https://community.peptidecritic.com/post/3578https://community.peptidecritic.com/post/3578Sun, 12 Apr 2026 16:25:47 GMT<![CDATA[Reply to NAD+ Buffered vs non-Buffered on Fri, 10 Apr 2026 17:55:31 GMT]]>I am finding my problem is that I need to eat more, not less. My results have been good, but recently I have hit a bit of a wall and need to transition to something approaching maintenance/build. It’s hard building muscle when your muscles don’t have fuel, even with the creatine, peptides, etc.

]]>https://community.peptidecritic.com/post/3434https://community.peptidecritic.com/post/3434Fri, 10 Apr 2026 17:55:31 GMT<![CDATA[Reply to NAD+ Buffered vs non-Buffered on Fri, 10 Apr 2026 16:40:09 GMT]]>Have you thought about eating more calories and then fasting 1 day/week or 1-2 times a moonth.

I'm on reta, KLOW, SLU-PP-332, and Tesa/Ipa blend and have considerably more weight to lose than you, but I've been keeping my daily calories about 400 under my TDEE and then doing a 24-36 hour fast once a week and I'm dropping weight and still have energy for the 5 days a week in the gym.

The fast creates the calorie deficit and otherwise maintaining a higher calorie count is keeping my metabolism and energy up. The day after I break the fast my energy lags, but by the 2nd day I'm back to normal.

]]>https://community.peptidecritic.com/post/3432https://community.peptidecritic.com/post/3432Fri, 10 Apr 2026 16:40:09 GMT<![CDATA[Reply to NAD+ Buffered vs non-Buffered on Fri, 10 Apr 2026 01:38:21 GMT]]>Buffering is a must for this rat.

]]>https://community.peptidecritic.com/post/3416https://community.peptidecritic.com/post/3416Fri, 10 Apr 2026 01:38:21 GMT<![CDATA[Reply to NAD+ Buffered vs non-Buffered on Fri, 10 Apr 2026 00:31:33 GMT]]>Yeah, my first couple days at 50mg was something. Puts the CJC flush to shame.

]]>https://community.peptidecritic.com/post/3413https://community.peptidecritic.com/post/3413Fri, 10 Apr 2026 00:31:33 GMT<![CDATA[Reply to NAD+ Buffered vs non-Buffered on Thu, 09 Apr 2026 20:06:26 GMT]]>@WowwyZowwy said in NAD+ Buffered vs non-Buffered:

y

I love NAD+ and pin 100mg daily after waking.

It can be an intense sensation in the first 5-10 minutes (I enjoy it now), I would suggest research be conducted at infrequent low dosing until response is individually characterized 👍 (as with any new material)

]]>https://community.peptidecritic.com/post/3392https://community.peptidecritic.com/post/3392Thu, 09 Apr 2026 20:06:26 GMT<![CDATA[Reply to NAD+ Buffered vs non-Buffered on Thu, 09 Apr 2026 19:27:42 GMT]]>@PeptidePete
Hmmmm…. Good to know, Thx! Happy with your results of your buffered?

]]>https://community.peptidecritic.com/post/3390https://community.peptidecritic.com/post/3390Thu, 09 Apr 2026 19:27:42 GMT<![CDATA[Reply to NAD+ Buffered vs non-Buffered on Thu, 09 Apr 2026 16:44:39 GMT]]>My buffered NAD already stings like hell for 5-10 seconds upon pinning, would not want even more of that 😕

]]>https://community.peptidecritic.com/post/3387https://community.peptidecritic.com/post/3387Thu, 09 Apr 2026 16:44:39 GMT