Reta & kidney studies
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This is the Baylor article that lists the data for all three studies
https://pmc.ncbi.nlm.nih.gov/articles/PMC12026077/pdf/UBMC_38_2456441.pdf -
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In my opinion, i take the highest dose i can take that you can meet your macros.
It makes no sense you take 8mg if you cant eat, by fixing 1 thing you break 2.
The studies on GLPs are mainly done for ppl over weight so yes they use high doses, but i guarantee that even at lower doses it helps with many things, lipids,insulin, heart, kidneys and probably a ton of other things.
The studies are also done with compliance in mind such as dosing frequency, imaging Elly telling everyone to take a daily Subq shot or even lower doses.
They need high doses and less frequency to sell…
I take 2mg a week split 3x M, W, F and im not doing it for weight loss.
As @randy Jeff has his views of Reta, the glucagon is the retain muscle component however Tirz is a great GLP and works as well as long as you can meet your daily macros.
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Primary will only scribe sema and refuses to scribe tirz w/o t2d. Kidney cancer was determined metabolic because the subject was morbidly obese. Subject does weight resistance 5x a week and currently meets all macros but still has fatty liver and insulin resistance after one year.
Thank you for your input. Just trying to do as much research as possible to not cause additional damage to remaining kidney. The fatty liver and insulin resistance will more likely do more damage than the Reta ever would is my current theory. -
Primary will only scribe sema and refuses to scribe tirz w/o t2d. Kidney cancer was determined metabolic because the subject was morbidly obese. Subject does weight resistance 5x a week and currently meets all macros but still has fatty liver and insulin resistance after one year.
Thank you for your input. Just trying to do as much research as possible to not cause additional damage to remaining kidney. The fatty liver and insulin resistance will more likely do more damage than the Reta ever would is my current theory. -
Just dropping information for anyone else in the future. I spent the day on clinical study sites. The people that were in the low dose studies of .5 and 1 had DKD (diabetic kidney disease). One group had starting eGFR >30 and another had >50. For reference a good eGFR is 90. The averages when completed were in the higher 80’s. I found a peer review of Reta and Tirz. Both are recommended for patients with DKD to improve function.
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@myb thank you for sharing that info. I'd had the vague notion that reta improved kidney disease... but admit to not having chased it down thoroughly.
One other thing to be aware of (you probably know, but others may not) is there are two ways to measure eGFR - the traditional computes it from Creatinine and the other from cystatin c. Cystatin C is usually considered to be more reliable... but always run it with inflammation markers like hscrp. The reason is that cystatin C can be thrown off by chronic inflammation in a way that will tank the eGFR calculated from it. I usually run both for this reason.
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Just dropping information for anyone else in the future. I spent the day on clinical study sites. The people that were in the low dose studies of .5 and 1 had DKD (diabetic kidney disease). One group had starting eGFR >30 and another had >50. For reference a good eGFR is 90. The averages when completed were in the higher 80’s. I found a peer review of Reta and Tirz. Both are recommended for patients with DKD to improve function.
@MyB Tesamorelin with Ipamorelin helps with visceral fat and fatty liver. I’m not sure of its effect on renal function but it’s definitely works to decrease abdominal girth. Worked for me and I had fatty liver a visceral fat that I couldn’t drop. Good luck
subjects cancer history.