Tirz and reta stack???
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Reta is tirz with a glucagon peptide. Now do the math. Is their GLP and GIP 1 :1 to a mg? Maybe there is something by increasing/titrating GLP-1 and GIP that is in the mix/math. Only one way to find out. "Pinch, pin and pray".
Reta is tirz with a glucagon peptide. Now do the math. Is their GLP and GIP 1 :1 to a mg? Maybe there is something by increasing/titrating GLP-1 and GIP that is in the mix/math. Only one way to find out. "Pinch, pin and pray".
Understood, and I likely should have started Tirz much lower than the max and titrated up, but I truly followed my prescribers orders and now regret it. But I have read multiple articles that the appetite suppression of Reta was actually designed to be 40% less that Tirz due to the increased effects of the Glucagon they added in? So I am not sure they were ever equal at the GLP1 level. This is all an experiment I guess.
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@Atlas said:
@crash2127 My suggestion is to download a calorie tracking app (I use Macro Factor), and track literally everything you eat for a week or two. It's all calories in, calories out. GLP medicines do not make you lose weight on their own - they just suppress appetite enough to put you in a calorie deficit.
For example: I'm 6'2" 197lbs, and I lift weights 4x a week, so my maintenance is about 3,100 calories a day. Right now I'm eating 2,600 calories a day, and losing about 1lb per week.
Ok, thanks. I'll look into it. I blame my Italian heritage and my Nona that lived with us growing up. MANGIA! for every meal until we all felt like we were going to throw up meatballs, lol. I just have a strong will now over feeling full!
Oh man, good Italian food is my weakness! I made aglio e olio last night, and I forgot that high-fat meals and GLPs don't play well
Anyway, I highly suggest getting to the gym at least 3 times a week. Even if you can't lift heavy, resistance training will prevent muscle loss and actually increase your daily calorie expenditure.
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Despite them being the same with respect to the GLP-1 and GIP agonists, it is important to note that many users note better hunger suppression (and booze, drugs, gambling, etc) suppression with Tirz than with Reta. A friend is on Reta and is hungry a lot, which in his case is good because he works out and needs to hit his macros. When I was on 10 mg Tirz, I had no desire to eat at all so i titrated myself back down. I am around 5mg now and increase or decrease +/- 1mg as needed to stay on goal.
Given the OP’s situation, a reset likely won’t make things worse an is likely to improve things based on on all I have read and watched. (We are not the target audience, but Countess of Shopping has been on GLP-1’s for 3 years and talks about stalls, resets, etc all the time. Worth checking her out, but be prepared for many long videos. Look for one on stalls and resets.)
Yeah, well, I’m just here for the research, man. - The Dude
If I haven’t liked your post, no offense. I have exceeded my daily allowance.
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Despite them being the same with respect to the GLP-1 and GIP agonists, it is important to note that many users note better hunger suppression (and booze, drugs, gambling, etc) suppression with Tirz than with Reta. A friend is on Reta and is hungry a lot, which in his case is good because he works out and needs to hit his macros. When I was on 10 mg Tirz, I had no desire to eat at all so i titrated myself back down. I am around 5mg now and increase or decrease +/- 1mg as needed to stay on goal.
Given the OP’s situation, a reset likely won’t make things worse an is likely to improve things based on on all I have read and watched. (We are not the target audience, but Countess of Shopping has been on GLP-1’s for 3 years and talks about stalls, resets, etc all the time. Worth checking her out, but be prepared for many long videos. Look for one on stalls and resets.)
@ResearchCat I love my Reta, enough hunger to get my proteins in has allow to not only maintain and gain more muscle. Due to it's 5-6 day half life. If I push it to 6-7 days you could actually finish a whole meal. I still watch what I eat though A good cheat day steak platter with fixing for me is bliss. If not I just reset with a dose on the 5-6 day when you feel them soft chocolate chips cookie calling.
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Yes, I generally take my Tirz Saturday night so I have Friday night and saturday as re-feed days, and run pretty tight during the week. For a while I was doing a 5 day cycle, but then I wasn’t eating enough, so I stopped. If we listen to our bodies, sometimes we can tune our dosing (specific to GLP-1’s) to optimize our goals and not lose a ton of muscle and/or tank our metabolism. But it can be hard to do when we’re watching the scale drop.
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I wish I had the same benefits as him on Cag, but not yet.
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This post is deleted!
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@jake_peptron Randy is a big fan of Tirz/Survo. I think if you search for ‘Ghetto Reta Stack’, you will find the thread on this.
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We all have a degree of insulin resistance. mitochondria burns fat. It is advised to optimize you mitochondria. Tune up your diet further, exercise past your comfort zone. You have options. Im sure there is someone who has research this further. If all fails you always have Reta.
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We all have a degree of insulin resistance. mitochondria burns fat. It is advised to optimize you mitochondria. Tune up your diet further, exercise past your comfort zone. You have options. Im sure there is someone who has research this further. If all fails you always have Reta.
We all have a degree of insulin resistance. mitochondria burns fat. It is advised to optimize you mitochondria. Tune up your diet further, exercise past your comfort zone. You have options. Im sure there is someone who has research this further. If all fails you always have Reta.
Very sound advice, thank you.
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@jake_peptron Randy is a big fan of Tirz/Survo. I think if you search for ‘Ghetto Reta Stack’, you will find the thread on this.
@jake_peptron Randy is a big fan of Tirz/Survo. I think if you search for ‘Ghetto Reta Stack’, you will find the thread on this.
Sounds interesting but that again is two GLP1s. I feel like at least the Cag, technically, isn't overloading the same receptors, but in theory should give a stronger appetite suppressant effect. It is all trial and error I guess.
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Just my two cents but your receptors are probably burnt out. That doctor did you dirty. I dont think you mentioned how long you were on Sema but going max dose from that to max dose of Tirz for an extended period would seem to have diminishing return. Also missing wayyy to much data on diet and calories to really help. Start tracking everything you eat immediately. One of two scenarios seem possible. You have been under eating so long your metabolism and hormones are shot and you need to come back down or off Tirz. Start eating again to reset everything. Or you are overeating which seems nuts at that dose of Tirz. Would love to hear what decisions you make and how you progress. For me its data data data. Track and adjust.
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Just my two cents but your receptors are probably burnt out. That doctor did you dirty. I dont think you mentioned how long you were on Sema but going max dose from that to max dose of Tirz for an extended period would seem to have diminishing return. Also missing wayyy to much data on diet and calories to really help. Start tracking everything you eat immediately. One of two scenarios seem possible. You have been under eating so long your metabolism and hormones are shot and you need to come back down or off Tirz. Start eating again to reset everything. Or you are overeating which seems nuts at that dose of Tirz. Would love to hear what decisions you make and how you progress. For me its data data data. Track and adjust.
@cc4part41 said:
Just my two cents but your receptors are probably burnt out. That doctor did you dirty. I dont think you mentioned how long you....
I was on Sema 6 months, last 3 at max dose. Insurance stopped paying and I was off 6 months before going to tirz with a tele-med provider who put me right on 15mgs. First 3 months were fine, went from 239 to 212. Last two months not so good, back up to 214. Added Cag just about a month ago, currently 1.25mgs, no side effects, but no appetite suppression. Yes, I should definitely track calories (i did during sema) but haven't thought about it with Tirz. I do not personally feel my eating has increased much, and would guess I am between 2200 to 2500 calories a day, but that is just speculation based on prior tracking. And I don't drink or eat sweets.
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@cc4part41 said:
Just my two cents but your receptors are probably burnt out. That doctor did you dirty. I dont think you mentioned how long you....
I was on Sema 6 months, last 3 at max dose. Insurance stopped paying and I was off 6 months before going to tirz with a tele-med provider who put me right on 15mgs. First 3 months were fine, went from 239 to 212. Last two months not so good, back up to 214. Added Cag just about a month ago, currently 1.25mgs, no side effects, but no appetite suppression. Yes, I should definitely track calories (i did during sema) but haven't thought about it with Tirz. I do not personally feel my eating has increased much, and would guess I am between 2200 to 2500 calories a day, but that is just speculation based on prior tracking. And I don't drink or eat sweets.
@crash2127 but do you move your body?
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@crash2127 but do you move your body?
@crash2127 but do you move your body?
Yes. I mentioned a few messages back, 3 days a week in the gym with light weights. I am a big walker. Probably 4 to 5 days a week getting in 4 to 5 miles at a time (live 10 minutes from Disney World so I go there to get the steps in). I by no means am a couch potato. I don't even watch TV. Don't even drink alcohol and no illicit drugs.
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What you are eating and how much is the unknown variable. Track to get a baseline then cut 250 to 500 a day if you can. Focus on hitting your daily protein target. Look into low calorie high volume meals to keep you full. That really helped me. Sounds like you walk alot but if you aren't already track your steps. You may find you over do it some days and then under on others. Find your baseline then increase steps by 2000 a day. Your body may have hit homeostasis with what you have been doing and need to make some adjustments to get it to adapt again. Lastly is what is your sleep like? Go to bed at the same time and wake up at the same time. Shoot for 8 hours. For me no caffeine after 2pm. Cold bedroom. Light blocking blinds. Would love to say I stay off my phone before bed but I dont. Lol. You're doing great. Track. Adjust. It will come. Always here to be a sounding board.
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What you are eating and how much is the unknown variable. Track to get a baseline then cut 250 to 500 a day if you can. Focus on hitting your daily protein target. Look into low calorie high volume meals to keep you full. That really helped me. Sounds like you walk alot but if you aren't already track your steps. You may find you over do it some days and then under on others. Find your baseline then increase steps by 2000 a day. Your body may have hit homeostasis with what you have been doing and need to make some adjustments to get it to adapt again. Lastly is what is your sleep like? Go to bed at the same time and wake up at the same time. Shoot for 8 hours. For me no caffeine after 2pm. Cold bedroom. Light blocking blinds. Would love to say I stay off my phone before bed but I dont. Lol. You're doing great. Track. Adjust. It will come. Always here to be a sounding board.
@cc4part41 said:
What you are eating and how much is the unknown variable. Track to get a baseline then cut 250 to 500 a day .....
Great advice, thank you! And my sleep sucks! I hit the pillow hard about 10/10:30 and pass out in minutes. But between 1 and 2 am I wake up thinking about every stupid ass thing I have to do the next day and I just can't shut my brain off. Get up at 6am for work, and start the day out fatigued because of it. Tried semax, selank, dsip non helped. My sleep was actually great until this past January when my daughter got medically discharged from the Navy and moved back with me. I raised her alone since she was 13 and she is my world, so it is constant worrying about her that has done me in. Well, again thanks for the encouragement.
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