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GLP's/Weight loss targeted peptides

Scheduled Pinned Locked Moved Peptide Discussion
22 Posts 6 Posters 1.8k Views 1 Watching
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  • atlas01A Offline
    atlas01A Offline
    atlas01
    wrote last edited by
    #2

    Google is your friend. Also search this forum for Randy's posts. Not trying to be rude, but learning how to find information for yourself will help you so much in life. Especially when it comes to injecting research chemicals directly into your body...

    BeeKindB 2 Replies Last reply
    -1
    • atlas01A atlas01

      Google is your friend. Also search this forum for Randy's posts. Not trying to be rude, but learning how to find information for yourself will help you so much in life. Especially when it comes to injecting research chemicals directly into your body...

      BeeKindB Offline
      BeeKindB Offline
      BeeKind
      wrote last edited by
      #3

      @atlas01 it's actually extremely rude, I tried google and thought man not only do I think I would benefit but I'm sure the community would also benefit from having one thread with all of the information. How HORRIBLE of me to "research" by asking people, you know A FORM OF RESEARCH...

      Just someone with a fridge full of research and a browser history that would concern my doctor.

      1 Reply Last reply
      -1
      • atlas01A atlas01

        Google is your friend. Also search this forum for Randy's posts. Not trying to be rude, but learning how to find information for yourself will help you so much in life. Especially when it comes to injecting research chemicals directly into your body...

        BeeKindB Offline
        BeeKindB Offline
        BeeKind
        wrote last edited by
        #4

        @atlas01 and GOOGLE - is mostly sponsored results so no, google is no one's friend.

        Just someone with a fridge full of research and a browser history that would concern my doctor.

        1 Reply Last reply
        0
        • atlas01A Offline
          atlas01A Offline
          atlas01
          wrote last edited by
          #5

          @beekind Here ya go.

          https://community.peptidecritic.com/topic/329/cagrilintide-weekly-research-protocol
          https://community.peptidecritic.com/topic/332/survodutide-weekly-research-dosing-protocol
          https://community.peptidecritic.com/topic/333/mazdutide-weekly-research-dosing-protocol

          BeeKindB 1 Reply Last reply
          1
          • atlas01A atlas01

            @beekind Here ya go.

            https://community.peptidecritic.com/topic/329/cagrilintide-weekly-research-protocol
            https://community.peptidecritic.com/topic/332/survodutide-weekly-research-dosing-protocol
            https://community.peptidecritic.com/topic/333/mazdutide-weekly-research-dosing-protocol

            BeeKindB Offline
            BeeKindB Offline
            BeeKind
            wrote last edited by
            #6

            @atlas01 you missed the entire point of my question/post. I know how to find Randy's dosing protocols. What I'm asking for is more along the lines of the receptors they target and at what levels.

            Just someone with a fridge full of research and a browser history that would concern my doctor.

            E 1 Reply Last reply
            0
            • BeeKindB BeeKind

              @atlas01 you missed the entire point of my question/post. I know how to find Randy's dosing protocols. What I'm asking for is more along the lines of the receptors they target and at what levels.

              E Offline
              E Offline
              Eleanor
              wrote last edited by
              #7

              @BeeKind
              I can only speak to the Survodutide, which you have the link above. I'm on 5.5 Tirz + 1.0 to 1.2 Survo. Although you will have a bit of nausea at first, do NOT believe what it says about Survo being an appetite suppressor (like Tirz is). When that visceral fat starts to dissolve and your blood glucose level rises, you will be huuuungry! If you have an affinity for sweets, look out! Just expect it.

              Can't speak to Mazdutide.

              Proud to be on a gubmint watch list

              BeeKindB 1 Reply Last reply
              3
              • E Eleanor

                @BeeKind
                I can only speak to the Survodutide, which you have the link above. I'm on 5.5 Tirz + 1.0 to 1.2 Survo. Although you will have a bit of nausea at first, do NOT believe what it says about Survo being an appetite suppressor (like Tirz is). When that visceral fat starts to dissolve and your blood glucose level rises, you will be huuuungry! If you have an affinity for sweets, look out! Just expect it.

                Can't speak to Mazdutide.

                BeeKindB Offline
                BeeKindB Offline
                BeeKind
                wrote last edited by
                #8

                @Eleanor Thanks - I guess I'm not wording this right. I'm looking for data- maybe chemical markers and levels. I'm trying to figure out in my own research which agonist is causing my GI issues and want to see what levels each of these effects each receptor. I saw a bar graph on here recently showing something similar but I don't believe it included all of them and I don't know if it was accurate for levels.

                Just someone with a fridge full of research and a browser history that would concern my doctor.

                E 1 Reply Last reply
                1
                • BeeKindB BeeKind

                  @Eleanor Thanks - I guess I'm not wording this right. I'm looking for data- maybe chemical markers and levels. I'm trying to figure out in my own research which agonist is causing my GI issues and want to see what levels each of these effects each receptor. I saw a bar graph on here recently showing something similar but I don't believe it included all of them and I don't know if it was accurate for levels.

                  E Offline
                  E Offline
                  Eleanor
                  wrote last edited by
                  #9

                  @BeeKind Sorry Bee, can't help you with that.

                  Proud to be on a gubmint watch list

                  1 Reply Last reply
                  1
                  • judgetooJ Offline
                    judgetooJ Offline
                    judgetoo
                    wrote last edited by
                    #10

                    Maybe these links will help you:

                    https://pep-pedia.org/peptides/cagrilintide
                    https://pep-pedia.org/peptides/survodutide
                    https://pep-pedia.org/peptides/mazdutide

                    E 1 Reply Last reply
                    1
                    • judgetooJ judgetoo

                      Maybe these links will help you:

                      https://pep-pedia.org/peptides/cagrilintide
                      https://pep-pedia.org/peptides/survodutide
                      https://pep-pedia.org/peptides/mazdutide

                      E Offline
                      E Offline
                      Eleanor
                      wrote last edited by Eleanor
                      #11

                      @judgetoo
                      These are interesting. It gives the half life for Survo but can't find it for the other 2. With Survo half life of 6 days, it explains a lot. Got the notion to take Survo on Thursday and Tirz on Friday and it helps cover Survo plummet and hunger. What that actually means is I guessed right.

                      Proud to be on a gubmint watch list

                      1 Reply Last reply
                      1
                      • Snake PepskinS Offline
                        Snake PepskinS Offline
                        Snake Pepskin
                        wrote last edited by Snake Pepskin
                        #12

                        IMG_0185.jpeg

                        @beekind Cag and Eloralintide are in a different class, so I didn’t include them in the graph.
                        But for contrast.

                        Traditional incretins (GLP-1 and GLP-1/GIP/Glucagon agonists like Retatrutide and Survodutide) cause a transient, mild increase in resting heart rate due to autonomic stimulation.
                        In contrast, both Cagrilintide and Eloralintide actually lower resting heart rate. This represents a complete divergence in how they interact with central autonomic nervous system circuits, offering a different cardiovascular footprint.

                        “Knowledge is the ultimate power.
                        It’s not what you know that defines you, it’s that which you share that defines you.”

                        BeeKindB 1 Reply Last reply
                        4
                        • Snake PepskinS Offline
                          Snake PepskinS Offline
                          Snake Pepskin
                          wrote last edited by
                          #13

                          97da1b05-580a-4e35-ae39-10959226c9cc-image.jpeg

                          “Knowledge is the ultimate power.
                          It’s not what you know that defines you, it’s that which you share that defines you.”

                          E 1 Reply Last reply
                          3
                          • Snake PepskinS Snake Pepskin

                            97da1b05-580a-4e35-ae39-10959226c9cc-image.jpeg

                            E Offline
                            E Offline
                            Eleanor
                            wrote last edited by
                            #14

                            @Snake-Pepskin Half lifes distinctly different that the published papers given in link above. Hmm. Thanks Snake.

                            Proud to be on a gubmint watch list

                            Snake PepskinS 1 Reply Last reply
                            0
                            • Snake PepskinS Snake Pepskin

                              IMG_0185.jpeg

                              @beekind Cag and Eloralintide are in a different class, so I didn’t include them in the graph.
                              But for contrast.

                              Traditional incretins (GLP-1 and GLP-1/GIP/Glucagon agonists like Retatrutide and Survodutide) cause a transient, mild increase in resting heart rate due to autonomic stimulation.
                              In contrast, both Cagrilintide and Eloralintide actually lower resting heart rate. This represents a complete divergence in how they interact with central autonomic nervous system circuits, offering a different cardiovascular footprint.

                              BeeKindB Offline
                              BeeKindB Offline
                              BeeKind
                              wrote last edited by
                              #15

                              @Snake-Pepskin thank you. This is more along the lines of what I was looking for I knew someone posted a bar graph. I'm going to look more into the others. It seems there's others around the corner too that are being tested, I was reading about a bioglutide, basically reta with IGF-1.

                              Just someone with a fridge full of research and a browser history that would concern my doctor.

                              1 Reply Last reply
                              0
                              • E Eleanor

                                @Snake-Pepskin Half lifes distinctly different that the published papers given in link above. Hmm. Thanks Snake.

                                Snake PepskinS Offline
                                Snake PepskinS Offline
                                Snake Pepskin
                                wrote last edited by
                                #16

                                @Eleanor

                                Yeah, some are. My AI must be drawing from a different pond. Survo,seems a bit long, and Eloralintide. I’ll look into it.

                                “Knowledge is the ultimate power.
                                It’s not what you know that defines you, it’s that which you share that defines you.”

                                RandyR 1 Reply Last reply
                                1
                                • Snake PepskinS Snake Pepskin

                                  @Eleanor

                                  Yeah, some are. My AI must be drawing from a different pond. Survo,seems a bit long, and Eloralintide. I’ll look into it.

                                  RandyR Offline
                                  RandyR Offline
                                  Randy
                                  wrote last edited by Randy
                                  #17

                                  @Snake-Pepskin or the Ai is just making things up, AI has read alot of brow science at this point. Sadly crap in crap out with Ai and when it comes to peptides on the interne there is alot of crap for it to ingest.

                                  "If it doesnt come in a needle. It doesn't work"

                                  Snake PepskinS 1 Reply Last reply
                                  4
                                  • BeeKindB Offline
                                    BeeKindB Offline
                                    BeeKind
                                    wrote last edited by
                                    #18

                                    @gym.rat possibly, but I'm trying to do some research to figure out if there's a better combo for me since I'm experiencing some GI issues on Reta. Maybe it's analysis paralysis, maybe it's just me doing a different type of research, some people's minds process things differently and it's ok.

                                    Just someone with a fridge full of research and a browser history that would concern my doctor.

                                    1 Reply Last reply
                                    0
                                    • BeeKindB Offline
                                      BeeKindB Offline
                                      BeeKind
                                      wrote last edited by
                                      #19

                                      @gym.rat yes, I'm currently only tolerating 1mg twice a week, anytime I try to do more in one dose I get violently sick. I've been eating better and trying to change my lifestyle while utilizing reta. I prioritize my protein. I will try the enzyme you recommended, thank you!

                                      Just someone with a fridge full of research and a browser history that would concern my doctor.

                                      1 Reply Last reply
                                      0
                                      • RandyR Randy

                                        @Snake-Pepskin or the Ai is just making things up, AI has read alot of brow science at this point. Sadly crap in crap out with Ai and when it comes to peptides on the interne there is alot of crap for it to ingest.

                                        Snake PepskinS Offline
                                        Snake PepskinS Offline
                                        Snake Pepskin
                                        wrote last edited by
                                        #20

                                        @Randy @eleanor
                                        I was too tired last night to verify.

                                        After I called it out for the wrong information:

                                        “You are completely right, and I appreciate the direct correction. The previous charts relied on estimated/synthetic pharmacokinetic parameters that did not align with official clinical data.
                                        To correct the record, here are the verified human terminal elimination half-lives and their primary literature sources:”

                                        c1cbcf3e-e5ca-4263-a693-bff0bb996d27-image.jpeg

                                        “Knowledge is the ultimate power.
                                        It’s not what you know that defines you, it’s that which you share that defines you.”

                                        E 1 Reply Last reply
                                        1
                                        • Snake PepskinS Snake Pepskin

                                          @Randy @eleanor
                                          I was too tired last night to verify.

                                          After I called it out for the wrong information:

                                          “You are completely right, and I appreciate the direct correction. The previous charts relied on estimated/synthetic pharmacokinetic parameters that did not align with official clinical data.
                                          To correct the record, here are the verified human terminal elimination half-lives and their primary literature sources:”

                                          c1cbcf3e-e5ca-4263-a693-bff0bb996d27-image.jpeg

                                          E Offline
                                          E Offline
                                          Eleanor
                                          wrote last edited by
                                          #21

                                          @Snake-Pepskin I don't recall you being called out and appreciate the info. Thanks for the new chart!

                                          Proud to be on a gubmint watch list

                                          Snake PepskinS 1 Reply Last reply
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