GLP's/Weight loss targeted peptides
-
@atlas01 you missed the entire point of my question/post. I know how to find Randy's dosing protocols. What I'm asking for is more along the lines of the receptors they target and at what levels.
@BeeKind
I can only speak to the Survodutide, which you have the link above. I'm on 5.5 Tirz + 1.0 to 1.2 Survo. Although you will have a bit of nausea at first, do NOT believe what it says about Survo being an appetite suppressor (like Tirz is). When that visceral fat starts to dissolve and your blood glucose level rises, you will be huuuungry! If you have an affinity for sweets, look out! Just expect it.Can't speak to Mazdutide.
Proud to be on a gubmint watch list
-
@BeeKind
I can only speak to the Survodutide, which you have the link above. I'm on 5.5 Tirz + 1.0 to 1.2 Survo. Although you will have a bit of nausea at first, do NOT believe what it says about Survo being an appetite suppressor (like Tirz is). When that visceral fat starts to dissolve and your blood glucose level rises, you will be huuuungry! If you have an affinity for sweets, look out! Just expect it.Can't speak to Mazdutide.
@Eleanor Thanks - I guess I'm not wording this right. I'm looking for data- maybe chemical markers and levels. I'm trying to figure out in my own research which agonist is causing my GI issues and want to see what levels each of these effects each receptor. I saw a bar graph on here recently showing something similar but I don't believe it included all of them and I don't know if it was accurate for levels.
-
@Eleanor Thanks - I guess I'm not wording this right. I'm looking for data- maybe chemical markers and levels. I'm trying to figure out in my own research which agonist is causing my GI issues and want to see what levels each of these effects each receptor. I saw a bar graph on here recently showing something similar but I don't believe it included all of them and I don't know if it was accurate for levels.
-
Maybe these links will help you:
https://pep-pedia.org/peptides/cagrilintide
https://pep-pedia.org/peptides/survodutide
https://pep-pedia.org/peptides/mazdutide -
Maybe these links will help you:
https://pep-pedia.org/peptides/cagrilintide
https://pep-pedia.org/peptides/survodutide
https://pep-pedia.org/peptides/mazdutide@judgetoo
These are interesting. It gives the half life for Survo but can't find it for the other 2. With Survo half life of 6 days, it explains a lot. Got the notion to take Survo on Thursday and Tirz on Friday and it helps cover Survo plummet and hunger. What that actually means is I guessed right. -
@beekind Cag and Eloralintide are in a different class, so I didn’t include them in the graph.
But for contrast.Traditional incretins (GLP-1 and GLP-1/GIP/Glucagon agonists like Retatrutide and Survodutide) cause a transient, mild increase in resting heart rate due to autonomic stimulation.
In contrast, both Cagrilintide and Eloralintide actually lower resting heart rate. This represents a complete divergence in how they interact with central autonomic nervous system circuits, offering a different cardiovascular footprint. -
-
@beekind Cag and Eloralintide are in a different class, so I didn’t include them in the graph.
But for contrast.Traditional incretins (GLP-1 and GLP-1/GIP/Glucagon agonists like Retatrutide and Survodutide) cause a transient, mild increase in resting heart rate due to autonomic stimulation.
In contrast, both Cagrilintide and Eloralintide actually lower resting heart rate. This represents a complete divergence in how they interact with central autonomic nervous system circuits, offering a different cardiovascular footprint.@Snake-Pepskin thank you. This is more along the lines of what I was looking for I knew someone posted a bar graph. I'm going to look more into the others. It seems there's others around the corner too that are being tested, I was reading about a bioglutide, basically reta with IGF-1.
-
@Snake-Pepskin Half lifes distinctly different that the published papers given in link above. Hmm. Thanks Snake.
Yeah, some are. My AI must be drawing from a different pond. Survo,seems a bit long, and Eloralintide. I’ll look into it.
“Knowledge is the ultimate power.
It’s not what you know that defines you, it’s that which you share that defines you.” -
Yeah, some are. My AI must be drawing from a different pond. Survo,seems a bit long, and Eloralintide. I’ll look into it.
@Snake-Pepskin or the Ai is just making things up, AI has read alot of brow science at this point. Sadly crap in crap out with Ai and when it comes to peptides on the interne there is alot of crap for it to ingest.
-
@gym.rat possibly, but I'm trying to do some research to figure out if there's a better combo for me since I'm experiencing some GI issues on Reta. Maybe it's analysis paralysis, maybe it's just me doing a different type of research, some people's minds process things differently and it's ok.
-
@gym.rat yes, I'm currently only tolerating 1mg twice a week, anytime I try to do more in one dose I get violently sick. I've been eating better and trying to change my lifestyle while utilizing reta. I prioritize my protein. I will try the enzyme you recommended, thank you!
-
@Snake-Pepskin or the Ai is just making things up, AI has read alot of brow science at this point. Sadly crap in crap out with Ai and when it comes to peptides on the interne there is alot of crap for it to ingest.
@Randy @eleanor
I was too tired last night to verify.After I called it out for the wrong information:
“You are completely right, and I appreciate the direct correction. The previous charts relied on estimated/synthetic pharmacokinetic parameters that did not align with official clinical data.
To correct the record, here are the verified human terminal elimination half-lives and their primary literature sources:”
-
@Randy @eleanor
I was too tired last night to verify.After I called it out for the wrong information:
“You are completely right, and I appreciate the direct correction. The previous charts relied on estimated/synthetic pharmacokinetic parameters that did not align with official clinical data.
To correct the record, here are the verified human terminal elimination half-lives and their primary literature sources:” -
@Snake-Pepskin I don't recall you being called out and appreciate the info. Thanks for the new chart!
@Eleanor lol, I didn't get called out. I called out my AI bot about it. And it was sorry, like my dog after she stole my sandwich.
Hello! It looks like you're interested in this conversation, but you don't have an account yet.
Getting fed up of having to scroll through the same posts each visit? When you register for an account, you'll always come back to exactly where you were before, and choose to be notified of new replies (either via email, or push notification). You'll also be able to save bookmarks and upvote posts to show your appreciation to other community members.
With your input, this post could be even better 💗
Register Login