GLP-1 effects on dopamine
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I think some may of missed the point of GLP-1 can chemically shunt dopamine.
After two years of use:
98% increased risk of any psychiatric disorders
195% higher risk of major depression
108% increased risk for anxiety
106% elevated risk for suicidal behaviorAs long as we are using AI.
Those exact percentages come directly from an observational study published in late 2024 using electronic health record database data (TriNetX).
While the numbers themselves are real quotes from that paper, the conclusion that GLP-1s "chemically shunt dopamine" to cause severe depression is an oversimplification and clinically misleading. Large-scale evaluations by regulatory agencies like the FDA, as well as broader clinical trial analyses, do not support a direct causal link.Loss of Dopaminergic Coping Mechanisms: For many individuals, eating functions as a primary, immediate mechanism for emotional regulation and dopamine stimulation. When a medication blunts that reward response, a patient loses a core coping mechanism without an immediate replacement, which can manifest clinically as temporary mood disruption, emotional flatness, or heightened anxiety.
I dont even doubt those percntages but numbers can always be misleading without context.
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I got an email from the VA recently saying that they are starting to open trials using GLP-1’s for alcohol and drug addiction, which means we will likely see a lot more on this in coming years. They are also starting to investigate psychedelics for TBI and PTSD.
Given the VA’s historical reputation, I see these as good both as a peptide researcher and as a veteran, since these are relatively cutting edge treatments.
@ResearchCat The problem here is that the effect only lasts as long as the person takes the drug. It also only stems the physical urge. It does nothing to help the mental issue behind what's causing the alcoholic to drink in the first place. GLP-1 would be a fabulous tool for alcoholism IF, and only IF, the alcoholic proceeded to get the mental help they needed through therapy, rehabilitation, and/or AA meetings. They would need to address the root cause of their problem. Otherwise, the relapse if they ever had to go off the drug would be detrimental. Just like the drug only fixes your metabolic issues while you take it, the same holds true for addiction.
Thank you for your service.
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Its real, so I guess it depends on how much it effects the individual. Me for example I have no desire to drink or smoke weed, I may have an occasional one and done, but I find myself to be way more productive and sleep is better. I think the whole picture needs to be looked at from 30,000 ft view. For many people if the pleasure of food was a hidden addiction you may need to re calibrate your system. The things that may have brought pleasure before like alcohol or sweet fatty foods for example will be affected by the dopamine recalibration. For me all the healthy changes and challenges have made me feel better and my dopamine is balanced and I now look forward to healthy routine changes like scheduled stretching, breathwork, cardio, healthy meal prep, my only addiction is shopping for peptides and researching healthy lifestyle changes. It all compounds and maybe some struggle with the change more than others but I'm not sure zooming in and looking only at the compound itself as the culprit is the answer. For most people is the caveat, of course there will probably extreme cases out there who just can't take it becasue of some obscure reason genetically. I would say its not a silver bullet but it is a really powerful tool, the work still needs to be done. You may find new pleasures over time and maybe your energy systems or something else needs to be reviewed and supported and the Reta is only making this obvious now as your dopamine system is operating without the huge spike and dips like it did before.
my only addiction is shopping for peptides
Funny how that works...
If you are losing weight at a more rapid weight the body tends to stopre toxins in fat. With your reved up metabolic rate you mmay be detoxifying at a higher rate
Big time fatty detox, and lots of B vitamins and others will further detox, making one feel like crap. B vits should be methylated only and don't OD yourself on them. My main problem is fatigue.
Everyone knows these peps only work as long as you're taking them. I know 2 people who've made the cut after a year off them, but those are paltry numbers. It is what it is. Given these FACTS, I'd still poke.
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@ResearchCat The problem here is that the effect only lasts as long as the person takes the drug. It also only stems the physical urge. It does nothing to help the mental issue behind what's causing the alcoholic to drink in the first place. GLP-1 would be a fabulous tool for alcoholism IF, and only IF, the alcoholic proceeded to get the mental help they needed through therapy, rehabilitation, and/or AA meetings. They would need to address the root cause of their problem. Otherwise, the relapse if they ever had to go off the drug would be detrimental. Just like the drug only fixes your metabolic issues while you take it, the same holds true for addiction.
Thank you for your service.
@kerryh It’s a fair point, but that is the same as with people using GLP-1’s for weight loss. Presumably - even if we know it isn’t true - people using these things are taking a holistic approach.
It’s actually well established that many GLP-1 users experience depression after losing weight because the problems driving them to eat didn’t go away with the weight. But it is still a powerful tool. And having experience with alcoholics, I can say that while the underlying issues remain, a few less lost jobs, car wrecks, and cocaine charges would make addressing the underlying issues more approachable.
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In regards to addiction, a GLP might provide a window. That's all any intervention provides, same as with Rehab. What's most important is that the person is truly sick and tired of where they are. If they want to change their life then they have to use all available resources to chase that new life with the same intensity they chased their addiction.
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@ResearchCat The problem here is that the effect only lasts as long as the person takes the drug. It also only stems the physical urge. It does nothing to help the mental issue behind what's causing the alcoholic to drink in the first place. GLP-1 would be a fabulous tool for alcoholism IF, and only IF, the alcoholic proceeded to get the mental help they needed through therapy, rehabilitation, and/or AA meetings. They would need to address the root cause of their problem. Otherwise, the relapse if they ever had to go off the drug would be detrimental. Just like the drug only fixes your metabolic issues while you take it, the same holds true for addiction.
Thank you for your service.
@kerryh I believe if you use it long enough you'll rewire new habits to maintain your new body and mind composition (epigenetics). If you pay attention you will learn your biology, diet, physic, learning what it takes to be in a healthy state. Mind, body and soul. If you have to microdose .5mg of reta for the rest of my life now in then I will, considering the consequences in the state of health most are in. I am out of this system of manage decline slowly killing you and bleeding your wealth.
2M
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@kerryh I believe if you use it long enough you'll rewire new habits to maintain your new body and mind composition (epigenetics). If you pay attention you will learn your biology, diet, physic, learning what it takes to be in a healthy state. Mind, body and soul. If you have to microdose .5mg of reta for the rest of my life now in then I will, considering the consequences in the state of health most are in. I am out of this system of manage decline slowly killing you and bleeding your wealth.
@EXTROPIAN I’m listening to a longevity researcher who is talking about GLP-1’s as a lifelong thing along with metformin and rapamycin. I am not a big fan of taking meds, or taking anything for life, but if we are talking about living past 100 (150 is what he is talking about) and being mentally and physically capable, I am willing to negotiate.
I am playing the longest game.
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@kerryh I believe if you use it long enough you'll rewire new habits to maintain your new body and mind composition (epigenetics). If you pay attention you will learn your biology, diet, physic, learning what it takes to be in a healthy state. Mind, body and soul. If you have to microdose .5mg of reta for the rest of my life now in then I will, considering the consequences in the state of health most are in. I am out of this system of manage decline slowly killing you and bleeding your wealth.
@EXTROPIAN Discussion and semi-debate:
How long is long enough to rewire a person? All supposition and no solid human trials, except for GLP's & very few others; the rest is guesswork. Consider if a person starts at a young enough age (birth thru 20's, perhaps), without extreme injuries and continues at length; yeah, maybe. If any later in life, probably not. My conjecture is just as valid as yours on this subject and I'm sick of the influencers pushing this for their own benefit ($$$$$).Want the obvious answer to pass the century mark? You'll probably have to live as they did in the early 20th century thru about the 1940's, with little chemical (or govt) interference in water and food; the air is questionable, depending upon where you live. To make it work today, you'd more or less end up living as The Amish do. Once the 'clean cycle' is broken and the family unit splits, it's downhill from there.
I can say these things with a type of experience that counts; 40+ hours per week, aged and injured people, some genetics involved, others not. Also, mental and emotional stressors have a major influence on a person's longevity; oftentimes breaking their desire to continue to live. Keep in mind, everyone you once knew and loved are likely gone and the landscape around you has become unrecognizable. I'm sure most here have seen something like this process and I see it every day.
If you still want to live to 100+, stem cells are the way to go, but you really need to save up those nickels and dimes to afford it.
Proud to be on a gubmint watch list
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@EXTROPIAN Discussion and semi-debate:
How long is long enough to rewire a person? All supposition and no solid human trials, except for GLP's & very few others; the rest is guesswork. Consider if a person starts at a young enough age (birth thru 20's, perhaps), without extreme injuries and continues at length; yeah, maybe. If any later in life, probably not. My conjecture is just as valid as yours on this subject and I'm sick of the influencers pushing this for their own benefit ($$$$$).Want the obvious answer to pass the century mark? You'll probably have to live as they did in the early 20th century thru about the 1940's, with little chemical (or govt) interference in water and food; the air is questionable, depending upon where you live. To make it work today, you'd more or less end up living as The Amish do. Once the 'clean cycle' is broken and the family unit splits, it's downhill from there.
I can say these things with a type of experience that counts; 40+ hours per week, aged and injured people, some genetics involved, others not. Also, mental and emotional stressors have a major influence on a person's longevity; oftentimes breaking their desire to continue to live. Keep in mind, everyone you once knew and loved are likely gone and the landscape around you has become unrecognizable. I'm sure most here have seen something like this process and I see it every day.
If you still want to live to 100+, stem cells are the way to go, but you really need to save up those nickels and dimes to afford it.
@Eleanor Don't forget, we are the rats. The trial is live. Dial down the chatter, more presence, more experience and enjoy the ride.
The greatest story ever told is yours. So live it the best you can. These peptides are a blessing. I now in then still question. Why are these peptides all the sudden out at a time when most are metabolically unhealthy? -
@EXTROPIAN I’m listening to a longevity researcher who is talking about GLP-1’s as a lifelong thing along with metformin and rapamycin. I am not a big fan of taking meds, or taking anything for life, but if we are talking about living past 100 (150 is what he is talking about) and being mentally and physically capable, I am willing to negotiate.
I am playing the longest game.
@ResearchCat in this state of the world I'm not hopeful for the future so I'm good with not extending my lifespan too long. But while I'm here Id like to be as healthy as possible to have a better quality of life.
Just someone with a fridge full of research and a browser history that would concern my doctor.
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@ResearchCat in this state of the world I'm not hopeful for the future so I'm good with not extending my lifespan too long. But while I'm here Id like to be as healthy as possible to have a better quality of life.
@ResearchCat in this state of the world I'm not hopeful for the future so I'm good with not extending my lifespan too long. But while I'm here Id like to be as healthy as possible to have a better quality of life.
@beekind That's the idea! Thank you!
@extropian I can't help but be amused when someone tells a 70+ year old to "enjoy the ride", as if I haven't lived to the fullest already. And "live it the best you can". What the heck fire do you think I'm doing?! NO offense meant; I just can't help but chuckle, so thanks for that.
These peptides are a blessing. I now in then still question. Why are these peptides all the sudden out at a time when most are metabolically unhealthy?
Agree with that completely.
Proud to be on a gubmint watch list
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@ResearchCat in this state of the world I'm not hopeful for the future so I'm good with not extending my lifespan too long. But while I'm here Id like to be as healthy as possible to have a better quality of life.
@beekind That's the idea! Thank you!
@extropian I can't help but be amused when someone tells a 70+ year old to "enjoy the ride", as if I haven't lived to the fullest already. And "live it the best you can". What the heck fire do you think I'm doing?! NO offense meant; I just can't help but chuckle, so thanks for that.
These peptides are a blessing. I now in then still question. Why are these peptides all the sudden out at a time when most are metabolically unhealthy?
Agree with that completely.
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@Eleanor I am 55 and still on the roller coaster ride anticipating the next turn. Is wonder completely gone after 70? Ah man, I want off this ride! lol And a red head. Irish?
@EXTROPIAN Slainte Bro!
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@ResearchCat in this state of the world I'm not hopeful for the future so I'm good with not extending my lifespan too long. But while I'm here Id like to be as healthy as possible to have a better quality of life.
@ResearchCat in this state of the world I'm not hopeful for the future so I'm good with not extending my lifespan too long. But while I'm here Id like to be as healthy as possible to have a better quality of life.
The future is going to be great. There will be some bumps and bruises, but if you rip the overlays of politics off, this is a great time to be alive - and the only one you get.
There is a very common human frailty that we indulge that the time we live in is both worse than every other time, and more consequential than every other time. Right now, everyone thinks the 80’s and 90’s were the best. But it’s kind of like everyone who is done with boot camp tells you stories about how great it was.
From a secular perspective, we are in what is called a fourth turning, which is going to be rough no matter what the current batch of idiots is doing. But most of us will be alive for the upswing. (Basically, we are at the ‘weak men make hard times’ period of the cycle. It is an actual thing, as it turns out.)
I was listening to David Sinclair this week and he was talking about how the first person who will live to be 150 is alive today. That’s amazing. Probably won’t be me.
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Tl;DR version of the above.
We can’t choose the times we live in; we can only choose what to do with the time we are given. - Gandalf
Yeah, well, I’m just here for the research, man. - The Dude
If I haven’t liked your post, no offense. I have exceeded my daily allowance.
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Tl;DR version of the above.
We can’t choose the times we live in; we can only choose what to do with the time we are given. - Gandalf
@ResearchCat I'm still ok with not living to 150. Its not promised that it will get better and with technology, AI, data centers, politics, the economy, war, hatred and the lack of humanity in humans, I don't see how any of those things improve without a major catastrophic event. So 75-85 years is ok by me. Life is getting far too expensive. I'm one of those who will probably work until I die because I wasn't given the tools I needed to make good financial decisions early in life so working until 150 sounds AWFUL.
Im still going to enjoy the life I have and do the best to make a better future for my child but I'm not chasing immortality.
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Before Reta, the Beaver enthusiastically did 3 set lifting workouts, swam sets until time to go to work (which is swimming for a beaver).
Reta, slowly decayed to 2 sets, minimal swim sets.
After doing the high dose SS-31 protocol, down to one lifting set per workout and I am in no hurry to get the beaver to the gym on time.
But the beaver feels great. Resting energy is like in its 20s. No more of that viscous friction in the legs when climbing stairs. Dopamine patches help a little. But at what point does one cycle off of Reta to readjust the brain chemistry? Too tell the truth, the beaver is kind of Jonesing for another SS-31 cycle. -
@kenhnsy due to the reduction in neurotransmitters there’s lots of things down river that can take place like vasoconstriction, nitric oxide uncoupling, and things related to antioxidant depletion. Up your antioxidants, polyphenols, and natural vasodilators. Do low dose and work up to not create a bottle neck which will crash your system and make symptoms worse.
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