Cagrilintide Weekly Research Protocol
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@PeptidePete did she start her rat at 1 mg? That's a very high starting dose for a research protocol
@Randy said in Cagrilintide Weekly Research Protocol:
@PeptidePete did she start her rat at 1 mg? That's a very high starting dose for a research protocol
Agreed.
Started on .5mg first week and she felt nothing, asked me to jack it up. The good news is no nausea or any sides on the 1mg, just killed all food desire so, in that regard, it worked great.
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@Randy said in Cagrilintide Weekly Research Protocol:
@PeptidePete did she start her rat at 1 mg? That's a very high starting dose for a research protocol
Agreed.
Started on .5mg first week and she felt nothing, asked me to jack it up. The good news is no nausea or any sides on the 1mg, just killed all food desire so, in that regard, it worked great.
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On my 4th week at .25mg's a week and I'm at 6mg's Tirz...after 4 weeks I'm feeling the buildup of the Cagri. It helps with food noise but what's cool about it is that it makes me feel full after a small portion of protein. Like, really full to where I don't want anymore. My problem over the years has been food noise and portion size...i feel like the combo of Tirz/Cagri is THE perfect answer for me. I think I'm sticking right here for now.
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The longer I use Cagri, the higher I'm going on dosing, although still low I'm at .375 for my 3rd week....Works for a few days then fades just in time for my Tirz pin.
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Not sure if this is the best place, didn’t want to start a new thread. Novo took a big hit because the latest CagriSema trials show it to be less effective than Tirzepatide alone. I know a lot of folks here are pairing Tirz with cagri with good results.
Good information to have available.
Honestly, based on my reading and (limited) experience, I don’t know why anyone would just use Sema instead of Tirz except maybe cost via traditional pathways.
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Safety Note:
If you normally tend towards LOW blood pressure, Cagri will drop it even lower AND that can trigger a resting heart rate increase to compensate (tachycardia) severe enough to cause an ER visit. Effects exacerbated if using Reta which also can have a BP lowering effect. My poor wife went 144bpm and 89/62bp. Be careful with this one if the situation applies to you.
Obviously this "side-effect" is a benefit if you tend towards a HIGH blood pressure.
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Safety Note:
If you normally tend towards LOW blood pressure, Cagri will drop it even lower AND that can trigger a resting heart rate increase to compensate (tachycardia) severe enough to cause an ER visit. Effects exacerbated if using Reta which also can have a BP lowering effect. My poor wife went 144bpm and 89/62bp. Be careful with this one if the situation applies to you.
Obviously this "side-effect" is a benefit if you tend towards a HIGH blood pressure.
@PeptidePete Thats a great warning. I wasnt aware cagri did this.
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@peptidepete did they have her do the Valsalva maneuver or did they have to intervene chemically?
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@peptidepete did they have her do the Valsalva maneuver or did they have to intervene chemically?
@MyB said in Cagrilintide Weekly Research Protocol:
@peptidepete did they have her do the Valsalva maneuver or did they have to intervene chemically?
My post was unclear- we did not go to the ER, although the conditions warranted it is what I should have written. She hates ERs due to prior experiences. I told her to put on her tightest leggings and that eased the symptoms within an hour or so. Valsalva is said to work well, as you noted, however it did not for her. She is feeling better today, 5 days subsequent to the injection.
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Currently researching Reta with a start at .5 mg/week then titrating by .25 mg each week. Currently researching Reta at 2mg once per week which seems to manage appetite and planning to research up to 4 mg of Reta weekly. Appetite control seems to fall off after a few days so started researching an additional research dose on day 4 each week @ .5 mg - with a plan to Titrate by .25 mg/week. Have been considering researching Cagri and replacing Day 4 Reta research dose with a Cagri research dose so the discussion here is helpful.
