Ipamorelin — Subcutaneous Research Dosing Protocol
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For research use only. Not medical advice.
Overview
Ipamorelin is a highly selective GH secretagogue that mimics ghrelin at the GHS-R1a receptor.
Its key strength is GH-specific release without raising cortisol or prolactin, making it one of the cleanest and most predictable GHRP options.
Most researchers use once-daily subcutaneous dosing to align with natural GH rhythms.Daily Dosing Protocol (Subcutaneous)
Standard Daily Range
100–250 mcg once daily
Most subjects start at the lower end and gradually increase to optimize sleep quality, recovery, and GH-related effects.
Titration Schedule
Weeks 1–2
100 mcg daily
Establishes baseline sensitivity and minimizes initial flushing or hunger waves.
Weeks 3–4
150 mcg daily
A mild increase to enhance GH pulse amplitude.
Weeks 5–8
200 mcg daily
This is the common “working dose” for most research setups.
Weeks 9–12
250 mcg daily
Upper-end daily dose for maximizing GH release without excessive receptor desensitization.
Timing
Best taken 30–60 minutes before bedtime on an empty stomach to line up with natural nocturnal GH release.
Avoid carbs/fats for ~1 hour before administration to prevent blunting the GH pulse.
Alternative timing used by some researchers:
Post-workout
Morning fasted
Both approaches are viable depending on goals.Cycle Length
Typical ipamorelin research cycles:
8–12 weeks on, followed by
2–4 weeks off to reduce receptor desensitization.
Some researchers run longer cycles when combining with GHRH analogs (e.g., CJC-1295 or MOD-GRF).
Common Research Notes
Hunger pulses may appear briefly after administration but usually diminish with repeated use.
Ipamorelin’s clean hormone profile makes it well suited for stacks with GHRH analogs.
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Hey Randy, I
My rat has had a nagging shoulder/arm issue for 6 years. I have no idea what I did. Maybe too many pushups in her 40’s? also I want to her trim down and build some more muscle. Could my rat research 4 peptides at once? BPC 157. CJC/IPAand RETA? -
Hey Randy, I
My rat has had a nagging shoulder/arm issue for 6 years. I have no idea what I did. Maybe too many pushups in her 40’s? also I want to her trim down and build some more muscle. Could my rat research 4 peptides at once? BPC 157. CJC/IPAand RETA?@jamiek I am currently researching tirzepatide, Glow(BPC, TB5, GHK), CJC/IPA, SS-31, and just started MOTS-C. Oh, and Semax.
For what you describe with respect to your shoulder, I’d strongly recommend either wolverine or Glow stack. I had persistent shoulder and knee pain from years of swimming and jiu jitsu, and being on Earth too long. A couple months on Wolv/Glow and I have no shoulder pain any more, and only occasional knee pain. And I am working out hard, and lifting heavier than ever.
So yes, you can absolutely run 4 or more peptides together. Start slow, get comfortable with how your body adapts, and increase dosages only when you’re confident with how your body is adapting.
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Hey Randy, I
My rat has had a nagging shoulder/arm issue for 6 years. I have no idea what I did. Maybe too many pushups in her 40’s? also I want to her trim down and build some more muscle. Could my rat research 4 peptides at once? BPC 157. CJC/IPAand RETA?@jamiek you can but pick one and add them many weeks apart. A lot of people just start a stack, have a histamine reaction and have to start over. Id also note some (including me) have significantly increased appetite with ipamorelin. CJC is the most common to cause histamine reactions in that category. If you are cutting tesa is likely your best bet.
If i were dealing with the issue you mentioned and wanted to cut some weight/attempt to repair the shoulder id do bpc and tirz or reta. After bpc try adding other stuff.
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Interesting, so if I am understanding correctly, start the bpc157 and continue my tirz then after the 8 week cycle switch to ipamorelin? I have been on tirz for 18 months. I was going to switch to Reta to lose more fat. People say it’s helps with the last 5 lbs. I do have my nutrition dialed.
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Some like reta. I dont. I was hungry. Tirz is the goat IMO. Adding cagri, survo or maz to tirz gets you past any stalls. We have a post on here about ghetto reta that might be worth a look. Also ipa might significantly increase your appetitte.
Just add one thing at a time and run it for a bit to test tolerance. That's the research protocol i'd suggest.
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Some like reta. I dont. I was hungry. Tirz is the goat IMO. Adding cagri, survo or maz to tirz gets you past any stalls. We have a post on here about ghetto reta that might be worth a look. Also ipa might significantly increase your appetitte.
Just add one thing at a time and run it for a bit to test tolerance. That's the research protocol i'd suggest.
@Randy It’s funny; a friend of mine is on reta and like it a lot but is increasing his dose because of food noise/hunger. I use tirz and he keeps trying to get me to move to reta but I am not having trouble with food noise on a very low dose.
Hence why I always say to take it slow and see what works best for you. Maybe I will try reta at some point, but right now I see no reason to mess with variables that aren’t causing problems.
