Has anyone tried Retatrutide while on Tirzepatide?

peptidepilot

Hi Guys,
I have a question for the community: has anyone here tried Retatrutide while on Tirzepatide? If so, what were the dosages, results, and side effects, if any?
Also, if you were already on a certain dose of Tirzepatide, did you reduce it when you added Retatrutide? If so, what were the doses for both the dual (2P) and triple (3P) agonists?
I am currently on Tirzepatide (2P) at 5 mg and plan to start Retatrutide (3P), but I can’t decide between two options:

Stop the 2P altogether and start Retatrutide at its starting dose(1mg).
Lower the doses of both, for example reducing Tirzepatide to 4 mg and starting Retatrutide(1mg) alongside it.
Has anyone been in this situation? Please share your experience. Thank you!

chrisd

I would stop Tirz....and your next scheduled injection...Inject Reta instead... Thats what I'm going to do... I was at 7.5 Tirz but will start Reta at 1 mg mainly because I had a bad experience with Reta back in April ...I think I titrated up too fast and it gave me panic attacks.. I was new at peptides and self injections and made some beginner mistakes, Tirz has been great...I've lost 30lbs since april but have been on a Plateau since Sept...time for a change

MmmmYah

@chrisd said:

I would stop Tirz....and your next scheduled injection...Inject Reta instead... Thats what I'm going to do... I was at 7.5 Tirz but will start Reta at 1 mg mainly because I had a bad experience with Reta back in April ...I think I titrated up too fast and it gave me panic attacks.. I was new at peptides and self injections and made some beginner mistakes, Tirz has been great...I've lost 30lbs since april but have been on a Plateau since Sept...time for a change

Any reason why you are switching earlier rather than titrating all the way up to 15 mg Tirz first?

Randy

If noise is the issue tirz is king. Titrate to max would be my vote. Ive run both. Glucagon increased my rats hunger

booker

I run both 2.5 mg tri Monday night 1 mg reta Friday morning

Justdabbling

I was debating the same thing but then i read about people stopping a glp only to have it be less effective when they go back to it later. So now Im thinking if I start reta, I'll probably stack it. Also, I just added the chengdu elora to stack the tirz, so might be a while before i touch the rt i have also bought

pep_researcher

Yeah my did it. But it didn't notice much difference. Was probably suffering from another condition that got detected on its comprehensive blood work, and when it started supplements to fix that, it started losing weight while eating proper meals while on medium dose Reeta.

boriswilliams

You can follow me

peptidepilot

@MmmmYah said:

@chrisd said:

I would stop Tirz....and your next scheduled injection...Inject Reta instead... Thats what I'm going to do... I was at 7.5 Tirz but will start Reta at 1 mg mainly because I had a bad experience with Reta back in April ...I think I titrated up too fast and it gave me panic attacks.. I was new at peptides and self injections and made some beginner mistakes, Tirz has been great...I've lost 30lbs since april but have been on a Plateau since Sept...time for a change

Any reason why you are switching earlier rather than titrating all the way up to 15 mg Tirz first?

No specific reason, I’ve just been seeing so much hype about Retatrutide everywhere lately that I’m really curious to learn more and thats why wanted to try it out. that's main driver behind switch

peptidepilot

@Justdabbling said:

I was debating the same thing but then i read about people stopping a glp only to have it be less effective when they go back to it later. So now Im thinking if I start reta, I'll probably stack it. Also, I just added the chengdu elora to stack the tirz, so might be a while before i touch the rt i have also bought

Same here. I am also curious to know. If someone tries Reta and decide to switch back to Tirzepatide later, will their previous effective dose of Tirzepatide still work? Or does trying Reta build up a tolerance that makes Tirzepatide less effective afterward? There are mix opnions and experiences out there that does make sense probably due to different body compositions/chemistry. Thanks

peptidepilot

@pep_researcher said:

Yeah my did it. But it didn't notice much difference. Was probably suffering from another condition that got detected on its comprehensive blood work, and when it started supplements to fix that, it started losing weight while eating proper meals while on medium dose Reeta.

would you care share more detials. like what before/after dose your rat was on for both Triz and Reta. whats medium reta dose. Thanks

peptidepilot

@Randy said:

If noise is the issue tirz is king. Titrate to max would be my vote. Ive run both. Glucagon increased my rats hunger

Yes, I'll probably stick to tirzepatide long-term. Food noise is still an issue, and I've plateaued on my current dose, so it's time to up it anyway. Thanks for reply.

dontfyourlife

I wouldn't combine them and they are designed as a stand alone drugs that can have intense side affects.

If you have the time (or inclination)...here is a video that breaks down the science of why not to. Just wayyy to much to summarize here.

https://youtu.be/Taj81n2-q9I

jdog_rat

Yes now. 15mg t, 3mg r. Feeling good. Eventually I will transition to only reta and cagri

MmmmYah

https://youtu.be/NdGKQ4aH7hI?t=840