Aavant TB-4 drop
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Until Recently, I was under the same impression, but they aren’t. Below is a basic Perplexity AI breakdown of how they differ. Now, I have heard people say if you have tb-500 it’s more than likely tb4. I’m not sure how true that is but there does seem to be a lot of overlap with the two. I’m sure someone on here can explain it better than I and without AI.
TB-500 and TB-4 (Thymosin Beta-4) are closely related but distinctly different peptides — TB-500 is a synthetic 7-amino acid fragment derived from the active site of TB-4, while TB-4 is the full 43-amino acid naturally occurring protein.[innerbody]
Structure & Origin
TB-4 is a naturally occurring peptide found in virtually every human cell, encoded by the TMSB4X gene, and plays broad roles in wound healing, tissue regeneration, and immune modulation. TB-500 (also called fequesetide or Ac-LKKTETQ) is specifically modeled after amino acids 17–23 of TB-4 — the segment responsible for actin-binding and cell migration. Because it’s a shorter fragment, TB-500 is significantly easier and cheaper to synthesize.@Pepe.la.peptide said in Aavant TB-4 drop:
Until Recently, I was under the same impression, but they aren’t. Below is a basic Perplexity AI breakdown of how they differ. Now, I have heard people say if you have tb-500 it’s more than likely tb4. I’m not sure how true that is but there does seem to be a lot of overlap with the two. I’m sure someone on here can explain it better than I and without AI.
TB-500 and TB-4 (Thymosin Beta-4) are closely related but distinctly different peptides — TB-500 is a synthetic 7-amino acid fragment derived from the active site of TB-4, while TB-4 is the full 43-amino acid naturally occurring protein.[innerbody]
Structure & Origin
TB-4 is a naturally occurring peptide found in virtually every human cell, encoded by the TMSB4X gene, and plays broad roles in wound healing, tissue regeneration, and immune modulation. TB-500 (also called fequesetide or Ac-LKKTETQ) is specifically modeled after amino acids 17–23 of TB-4 — the segment responsible for actin-binding and cell migration. Because it’s a shorter fragment, TB-500 is significantly easier and cheaper to synthesize.This was one of those that was confusing in the beginning of my research, some vendors had TB FRAG 17-23, TB500, or TB4 and I figured there must be differences but what. Found this article which helped explain. It was in simple terms for my brain
https://allaboutpeptides.com/tb4-thymosin-beta-4-vs-tb-500/
Love your username btw
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@wisgal64, thanks for sharing the article, I was wondering how Frag 19-23 was related. Have you run a protocol with either and if so thoughts? I agree with @commander vendors are using the names interchangeably, and personally I feel like biggest learning curve when getting started in peptides is learning the vernacular.
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@pepe.la.peptide & @wisgal64
Mind blown!!!!!!!
Now I know why the studies cited by that YouTube guy when talking about 500 don’t mention 500. But instead site TB-4.
I feel misled. Juan the mouse did 500. Wonder if the results with actual TB-4 would be the same.Also, would we not know the exact one we are getting via AAdvant once testing has concluded?
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Unfortunately I think some vendors are using the names interchangeably, when they are different things.
@Commander They are. More often than not its tb4 but labeled something else
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@wisgal64, thanks for sharing the article, I was wondering how Frag 19-23 was related. Have you run a protocol with either and if so thoughts? I agree with @commander vendors are using the names interchangeably, and personally I feel like biggest learning curve when getting started in peptides is learning the vernacular.
@Pepe.la.peptide said in Aavant TB-4 drop:
@wisgal64, thanks for sharing the article, I was wondering how Frag 19-23 was related. Have you run a protocol with either and if so thoughts? I agree with @commander vendors are using the names interchangeably, and personally I feel like biggest learning curve when getting started in peptides is learning the vernacular.
I've researched TB500(actually TB4 according to the CoA), from a couple of different vendors, PP and certified pep. Worked well for knee injury.
I do have a few vials of TB500 17-23 from EZ in the freezer, just looked at the CoA, it says TB500 in the Results.
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@Juan-Doe said in Aavant TB-4 drop:
When it says frag, what does that mean?
Frag means Fragment.
I did a quick search to get the full details:
It means it's not the full Thymosin‑β4 (TB4) peptide, but a short slice of it's amino sequence.
TB4 is a 43-amino-acid peptide.
A fragment like 17–23 means:- You take only amino acids #17 through #23
- That’s a 7‑amino‑acid micro‑segment of the original TB4 chain
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I think Uncle wang would say it best TB-500 and Frag 19-23 same, same...Tb4 and TB-500 same, same but different!
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I came across an older post from someone who has had years of experience with Peps and has designed protocols, well respected in the Reddit community. This is regarding Frag 17-23.
Her comment to someone asking about TB 17-23 and dosing.
"Not recommended. That's TB Frag 17-23. This is a fragment that targets primarily angiogenesis. So it's more for vascular disease and heart disease research.
Not a doctor, not medical advice, for research purposes only and for research discussions only."
I'm continuing to dig into this further.
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I also researched with TB500… honestly all I noticed was an increase in cherry angiomas, those little red dots that look similar to moles… which is most likely due to the increase in angiogenesis. Having said that, I am strongly considering ordering TB4 if it’s still available during the next Aavant drop, especially since the 01 (yellow cap) batch has already been tested and verified though the Aavant test group on TG. I am interested to see if there is a noticeable difference.
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I ran it. And no complaints there.
But now, will run TB4 next. Still sourcing materials needed for my next research cycle.
Any info is helpful.Honestly, I would have rather run TB4 instead of TB500.
@Juan-Doe that's what I'm thinking too. I read that TB500 is a fragment of TB4 which makes it cheaper and the fragment has not been studied like the full chain of TB4 has. All the studies showing the benefits were from TB4...Sounds like TB4 would be better but who knows without any real studies yet.
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@Juan-Doe that's what I'm thinking too. I read that TB500 is a fragment of TB4 which makes it cheaper and the fragment has not been studied like the full chain of TB4 has. All the studies showing the benefits were from TB4...Sounds like TB4 would be better but who knows without any real studies yet.
@JustAgirl EXACTLY! All the studies that are mentioned by so called “experts” mention TB4 and not TB500.
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any advice on ordering this thru the bot? or does it walk you through it?
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@brandenscheidecker edit: go to this topic. I made a post that shows how to start order with the bot including screenshots. Bot walks you through the process.
https://community.peptidecritic.com/post/2626 -
I just got one it was stupid easy! thank you!
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yes i am in the same boat, I was going to buy a 3d printer but now it looks like im buying Aavant lol
