Long term storage of reconstituted peptides
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Freezing reconstituted retatrutide will destroy the peptide.
Once water is added, freezing causes aggregation and structural damage that permanently degrades potency. There is no upside.
Lyophilized vials, on the other hand, are stable for years when kept sealed and frozen.
On top of that, freezing liquid can crack glass vials due to expansion.
Do not freeze after reconstitution. Keep vials dry and frozen, and only reconstitute one vial at a time.
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Thanks for the fast reply. Doesn't seem like there is a way to reconstitute just what we need then. If I reconstitute all 48mg in each vial it would go bad long before we have had a chance to use it @1mg each per week. My understanding is once reconstituted it will last about a month when refrigerated. We'd only have used 8mg during that time leaving 40mg of it to go bad.
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We have actually just shipped off some tirz and mots-c to have them tested 60 days after recon, a week on the counter, 2 weeks etc.
we wont have answers for you before that but what i can tell you is the general consensus is 60 days refrigerated.
One of the biggest mistakes we see when people get started is buying big bottles. Im researching 15mg tirz and i only buy 30mg bottles.
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Copy that. I had a sinking feeling....
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Interested in your stability reports though. Great idea.
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@randy Hey Randy. Can you send reconstituted peptides to the lab for testing?
My deal is that i take Reta low dose around 1.5mg a week, so a 30mg bottle last a while.
I would love to ship out some remainder of Reta in a cartridge that is around 3months old to see how it holds up.
Im actually willing to send 1 every month to see how long they last… 3 months, 4 months, up to 6 months
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you can but you would need a baseline from the batch first. Its also about 300 per test. The tests i mentioned above are not cheap.
shipping out the remainder of a cartridge wouldnt tell us much aside from whats left. With these sorts of tests you have to waste entire bottles.
we are testing Tirz/Maz/MOTS and that should give us a good idea of peptide life outside of the fridge.
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@randy hey buddy. When i first started i didn’t label my peptides once reconstituted and MotsC when I started the batch it would give me like a 15min sorta flush, good sting feeling.
Then i think the pen cartridge went too long and the last injection gave me a major reaction with a welt, do you think that could of been the peptide went bad?
I stopped because i opted to do I mitochondria protocol that starts with FOX04 30mg split in 3 shots for 2-3 weeks. That one is funny because that one feels like i got stung by a wasp. I split 50ml on each butt cheek.
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if you go on reddit and look up MOTS-C you will find a large number of posts about anaphylaxis/hives etc. For some the peptide fits in the histamine receptors just right. For others they will never have an issue. Sometimes a reaction hits after a few weeks of use. Its reasearch after all.
I never noticed any stinging with MOTS-C. Im also not the biggest fan of it. For me its just NAD light. Everyone is different but the influencers really latched on to this one once they couldnt say the word retatrutide on tiktok anymore.
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Freezing reconstituted retatrutide will destroy the peptide.
Once water is added, freezing causes aggregation and structural damage that permanently degrades potency. There is no upside.
Lyophilized vials, on the other hand, are stable for years when kept sealed and frozen.
On top of that, freezing liquid can crack glass vials due to expansion.
Do not freeze after reconstitution. Keep vials dry and frozen, and only reconstitute one vial at a time.
@Randy I am quite curious about the damage to peptides when frozen. Are the peptides not frozen in order for them to be lyophilized? Would the speed of the freezing process have an effect? Do they flash freeze before they are lyophilized? Do they have them in a non water based solution for them to be lyophilized? I would be interested in testing results for damage if there are any resources. My interest is more about inadvertently freezing them in a fridge that got to cold or while traveling in a cold climate.
