GHK Cycle
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Going to start researching this next week and see this question here. Planning on starting with 1mg 2 days, 1.5mg 2 days then 2mg ongoing. Either 5 days on 2 days off or 60 days/30 days. Can any experienced researchers share their thoughts on the cycle and titration. Please and thank you.
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I have only researched GHK as part of Glow stack, typically in the 2.5-3mg daily range. I have done both 5/2 and 7 days a week for 2-3 months and haven’t noticed any difference.
There is some discussion/disagreement about whether the 2 days off really helps receptors refresh or not. I think of the 2 days off as an excuse to not inject the rat, have to fast, or whatever. IMO, it is just a matter of preference.
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No expert here
I just completed a cycle of GHK, First week was .5mg for 3 days to make sure no reactions other than that awful sting. Then bumped to 2mg daily for remainder of the month. Cycle off for a month, then plan to try Klow. I do see varying opinions/info on protocols, makes it confusing. But landed on this protocol for what some would refer to as a more intense approach rather than conservative at least from what I've read -
I've researched various GHK subq protocols up to 20mg daily, posted them here in the GHK thread. Currently 3mg am, 3mg pm, it has a very short half-life, ergo, multiple daily pins for those who are serious about seeing benefits.
3000+ genes upregulated, none downregulated. No evidence of tachyphylaxis, it works via gene expression modulation. Why would you ever want to "cycle" it? Based on my current understandings, I will "never" go off of it.
My labs, run every 4-6 weeks, are pristine. As always in this space, 99.9% of what you see and hear is utter baseless bullshit, you are well served to conduct your own deep dive.
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I've researched various GHK subq protocols up to 20mg daily, posted them here in the GHK thread. Currently 3mg am, 3mg pm, it has a very short half-life, ergo, multiple daily pins for those who are serious about seeing benefits.
3000+ genes upregulated, none downregulated. No evidence of tachyphylaxis, it works via gene expression modulation. Why would you ever want to "cycle" it? Based on my current understandings, I will "never" go off of it.
My labs, run every 4-6 weeks, are pristine. As always in this space, 99.9% of what you see and hear is utter baseless bullshit, you are well served to conduct your own deep dive.
@PeptidePete said in GHK Cycle:
I've researched various GHK subq protocols up to 20mg daily, posted them here in the GHK thread. Currently 3mg am, 3mg pm, it has a very short half-life, ergo, multiple daily pins for those who are serious about seeing benefits.
3000+ genes upregulated, none downregulated. No evidence of tachyphylaxis, it works via gene expression modulation. Why would you ever want to "cycle" it? Based on my current understandings, I will "never" go off of it.
My labs, run every 4-6 weeks, are pristine. As always in this space, 99.9% of what you see and hear is utter baseless bullshit, you are well served to conduct your own deep dive.
interesting, I was under the impression it had to be, mainly because of the copper and desensitization
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@PeptidePete said in GHK Cycle:
I've researched various GHK subq protocols up to 20mg daily, posted them here in the GHK thread. Currently 3mg am, 3mg pm, it has a very short half-life, ergo, multiple daily pins for those who are serious about seeing benefits.
3000+ genes upregulated, none downregulated. No evidence of tachyphylaxis, it works via gene expression modulation. Why would you ever want to "cycle" it? Based on my current understandings, I will "never" go off of it.
My labs, run every 4-6 weeks, are pristine. As always in this space, 99.9% of what you see and hear is utter baseless bullshit, you are well served to conduct your own deep dive.
interesting, I was under the impression it had to be, mainly because of the copper and desensitization
@PeptidePete said in GHK Cycle:
I've researched various GHK subq protocols up to 20mg daily, posted them here in the GHK thread. Currently 3mg am, 3mg pm, it has a very short half-life, ergo, multiple daily pins for those who are serious about seeing benefits.
3000+ genes upregulated, none downregulated. No evidence of tachyphylaxis, it works via gene expression modulation. Why would you ever want to "cycle" it? Based on my current understandings, I will "never" go off of it.
My labs, run every 4-6 weeks, are pristine. As always in this space, 99.9% of what you see and hear is utter baseless bullshit, you are well served to conduct your own deep dive.
interesting, I was under the impression it had to be, mainly because of the copper and desensitization
Zero evidence of any form of tachyphylaxis in any literature. Lots of bro science comments about it though...lol. Please dig into the risk of the copper in GHK, not possible because it's bound, no risk. If you discover evidence to the contrary, please update the thread.
BTW I love your posts, great to see you on here
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@peptidepete thanks for the information
sometimes I get long winded lol -
I've researched various GHK subq protocols up to 20mg daily, posted them here in the GHK thread. Currently 3mg am, 3mg pm, it has a very short half-life, ergo, multiple daily pins for those who are serious about seeing benefits.
3000+ genes upregulated, none downregulated. No evidence of tachyphylaxis, it works via gene expression modulation. Why would you ever want to "cycle" it? Based on my current understandings, I will "never" go off of it.
My labs, run every 4-6 weeks, are pristine. As always in this space, 99.9% of what you see and hear is utter baseless bullshit, you are well served to conduct your own deep dive.
@PeptidePete
I’ve seen your higher dose protocols in previous posts. I’ve also seen your hand (LOL) and for your age, It’s pretty unbelievable. I’m sold!
I’ve been on about 1.5mg for a month now. Problem is, in addition to the sting, I get an allergic welt wherever inject. It’s always gone within 24 hours. But I can’t imagine doing those higher doses and what my welt would look like!
I’ve heard different people experience more or less reaction, depending who the vendor is. Have you experienced this? -
I started the 3mg in the AM and 3mg in the PM today!!
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@jackie Hope all goes well!
Thanks! I upped from 3mg to 4mg a few weeks ago. No issues. I thought what @peptidepete said made sense and I have a stash in the freezer, so why not try it?
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There are a few doctors on youtube (Dr. Alex Tatem and Dr. Ashley) who both say that ghk-cu are "well-tolerated" in the body, but I've also read horrible stories about people getting painful welts, swelling, and other reactions from taking it, which freaks me out a little. Are you taking it primarily for skin/hair benefits or to promote healing? I've also heard that you need to take a zinc supplement if you're taking GHK-Cu? There seem to be so many contradictions about this one !
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Forum blocks my "likes" after 20 per day <sad face> You all are funny..lol
Look, there is a case also to be made that signaling on a genetic level does not benefit from dosing more frequently than once every one or two days. Is a whisper sufficient? Or frequent shouts more effective? We just don't know because there are no human case studies.
With that said I observed no evidence that heroic doses cause any deleterious effects. N=1 for what that's worth, ya know? Did not notice blue tinting either, but that would be kind of cool. "No tats or piercings but I am blue"...haha!
65 year old hands today. Remember I live in Nevada with 10% typical humidity. Thank FLGR242 for the increased vascularity (different thread).
As previously mentioned, based on no hard evidence whatsoever, it is my opinion GHK subq may be a very beneficial agent for us older folks. Only time will tell.
Also, go do a search for the speed at which skin cells turnover, that is one very compelling reason I do not cycle. Make sense?
Cheers-
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Oh- as noted in the "other" GHK thread- Pain.
Absolutely injection site specific! I hit the wrong spot, it hurts sometime for 24-36 hours. To the extent it can wake me up at night.
BUT you have to find the spot that is right for YOU. For me the sides or especially good is upper half or upper sides of butt cheeks. That is my go-to area. If you don't find the right spot, it is too painful to maintain a regimen.
I use a Gansulin pen with BD Nano 2nd Gen Pen Needles, 4mm x 32G FWIW.
Also I dilute a 100mg vial with 6ml water. There are multiple ways to make that happen, figure out what works for you. I use that example only as a dilution ratio reference not a reconstitution/dosing reference! So many reconstitution calculators for folks to use, that is a foundational skill for any researcher.
ALSO....lol...the pain is not an indication of damage being done. It feels like acid is dissolving your flesh, but it is not and your flesh is a-ok...lol
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There are a few doctors on youtube (Dr. Alex Tatem and Dr. Ashley) who both say that ghk-cu are "well-tolerated" in the body, but I've also read horrible stories about people getting painful welts, swelling, and other reactions from taking it, which freaks me out a little. Are you taking it primarily for skin/hair benefits or to promote healing? I've also heard that you need to take a zinc supplement if you're taking GHK-Cu? There seem to be so many contradictions about this one !
Are you taking it primarily for skin/hair benefits or to promote healing? I've also heard that you need to take a zinc supplement if you're taking GHK-Cu? There seem to be so many contradictions about this one !
Zinc supplementation w/GHK = bro science. No basis, if you find one please post it and let us know? Zinc is great for those who are deficient, but AGAIN, the copper in GHK is BOUND, it is not affecting your copper levels. Important to understand this!
Research the 3000 gene upregulations. Hair/skin is 2/3000. To understand is to be stunned. Go deep.
YouTube/IG/etc is 99.9% worse than worthless recycled BS. Kristi Sawicki is good and I respect her. She is on the verge of "selling out" though...lol
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@peptidepete It’s a slow day when i don’t cap my like limit by noon.
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@peptidepete encouraged me, lol I guess I am easily swayed.
I am taking it for skin and hair, mainly. I am a 10 year breast cancer survivor who had 1.5 years of very harsh treatments. One of my drugs was called the Red Devil and it lived up to it's name. I am currently, thankfully, considered No Evidence of Disease, which is as good as it gets for TNBC. However, cancer being the gift that keeps on giving, I have had problems from the treatments. The skin on my arms became very thin, it bruises and tears easily. That has been greatly improved the past 6 months! I have noticed my facial lines are reduced, so that was a plus, too. My hair took about 5 months to respond. I lost all my hair to chemo and it grew back about 70%. I had a few spots where it didn't grow back. My hairstylist hid it very well. My hair is growing like a weed now and it looks very healthy. The best part, I have hair growing in the previous bald spots. It's very exciting!
Lately I am dealing with the skin that was damaged from radiation. I had 33 regular treatments and 5 "targeted boosts" at the end It just ruins the skin (no brainer though - radiation and live - easy choice). Last fall my reconstructed implant ruptured (manufacture recall on product, yay me!) and now I am dealing with silicone damage on the inside. That skin developed cellulitis after my January surgery. I am going to have to have another surgery in the next few weeks, because of this. I don't think that the GHK-cu will help that area, but you never know!
I always laugh that I am the healthiest sick person around. I am fit and very active. I have been a fitness instructor on the side for 30 years.
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2 different research subjects in my house. RS1-experienced the sting twice the first week. I'm not going to sugar coat it, as Peptidepete that said "it stung like a bitch" , and it did, but eventually subsided. Top of the thigh is a no go for me. I switched course found better sites and a different method for injecting.
RS2- experienced no pain, bragged about it even, laughed at me when I was in pain, thought I was exaggerating lol UNTIL the 29th night, he decided to try the inner thigh. 'Bout 2am I heard a very shrill sound, had no idea his voice could go that high. I tried to be sympathetic, I really did, but the only thing that came out of my mouth was the devil incarnate got ya huh? LOL
Everyone reacts differently. I hope you have a good experience
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I can’t imagine using my thigh! Ouch. I use my glutes and it is not too bad
