Ideas for my aged mother
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Hope this is the correct group for this. My mother is 84 and is struggling with high blood sugar and being fat and bad eyes. She tried ozempic a couple years ago and it was working, then she lost sight in one of her eyes (glaucoma and cornea issues). Don't know if it was causation or correlation. She got excited when she found out she could get mounjaro for free through her insurance plan, but the doctor said she won't prescribe it because of her eyes.
Now she is discouraged (plus she is depressed because my dad died in January after 65 years of marriage). I can't get her to stop eating sweets or to exercise because her joints hurt. Are there any peptides that you know of that might help her with weight/sugar/healing that are not a glp1?
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I'd start with her food. Carnivore, with a small amount of fruit
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Seems like her doctor may be confusing Monjauro (tirzepatide which is a GIP/GLP) with GLP1s. Reseach studies show that Tirzepatide is associated with a significantly lower risk of primary open-angle glaucoma and ocular hypertension compared to GLP-1 s. In fact, . findings suggested potential neuroprotective effects from its dual GIP/GLP-1 action. https://www.sciencedirect.com/science/article/abs/pii/S0002939425006531
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Fix that diet before anything else. No sugars and no grains, full stop. Then maybe look at one of the GLPs. Got to get that inflammation down so I'd look at KPV or maybe SS-31 for mito damage. Both of these names are on my research list for the upcoming week. Depending on how I respond I've been thinking about putting my own mother on them as a repair cycle. The safety profile for both probably ranks at the top of the pyramid as well. SS-31 has FDA trials / approval at 6 month run with heavy doses. KPV is a tiny peptide that is about as safe as it gets when you consider the data points we do have. Dr. Tatem on YT has a really good video about it.
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Hope this is the correct group for this. My mother is 84 and is struggling with high blood sugar and being fat and bad eyes. She tried ozempic a couple years ago and it was working, then she lost sight in one of her eyes (glaucoma and cornea issues). Don't know if it was causation or correlation. She got excited when she found out she could get mounjaro for free through her insurance plan, but the doctor said she won't prescribe it because of her eyes.
Now she is discouraged (plus she is depressed because my dad died in January after 65 years of marriage). I can't get her to stop eating sweets or to exercise because her joints hurt. Are there any peptides that you know of that might help her with weight/sugar/healing that are not a glp1?
@Hammertime65
i would work toward diet first of all. maybe try a SUPER small dose reta to get the cravings in check. if the glp1s are scary from the retina failure. i saw cagri and tesofensine use different pathways. but ultimately. the way they are eating and living may lose another eye anyways. so you gotta balance the good with the bad with some of the options.-you can do something like cartalax/glow/klow/wolverine for healing.
-as for joints something like aod 9604 was seen helpful with cartilage repair here.
https://pubmed.ncbi.nlm.nih.gov/26275694/
-was reading a thing on ss 31s effect on eye health. here. https://pmc.ncbi.nlm.nih.gov/articles/PMC4921212
-could do dsip/ epitalon /pinealon and nad for a lot of cognition help. circadian rhythm. etc.
-semax for mood and a boatload more
-glutathione for more repair.tldr the options are endless. but none of it will help if the diet is terrible. just gotta find something that motivates. whatever it may be. however small. i wish you the best of luck though.
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@brithus My guess is that since vision loss is a low incidence side effect of using GLP-1’s, and she lost vision while using one, she is at further risk with continued use. It is a fair concern. That being said, depending on her overall health and primary concerns, she may judge it to be worth the risk.
I have had vision problems in the past and was surprised when I recently found out about that side effect. But then, my sister in law had a stroke in her eye and lost partial vision and she wasn’t taking anything. The normal risk is 1/10,000 and the risk with GLP-1’s is 1/5,000.
At 84, all bets are off. Might try Glow/Klow, Dihexa, Epitalon, and SS-31, depending on what physical and mental rehab she is trying. Glow/Klow has been a game-changer for me in my late 50’s. I have no joint pain and am lifting heavier than ever.
Diet, exercise, and mental engagement are key.
Sorry to hear about your father.
Loneliness at that age is tough. Get her visiting friends and/or engaged with social groups if you can. -
Hope this is the correct group for this. My mother is 84 and is struggling with high blood sugar and being fat and bad eyes. She tried ozempic a couple years ago and it was working, then she lost sight in one of her eyes (glaucoma and cornea issues). Don't know if it was causation or correlation. She got excited when she found out she could get mounjaro for free through her insurance plan, but the doctor said she won't prescribe it because of her eyes.
Now she is discouraged (plus she is depressed because my dad died in January after 65 years of marriage). I can't get her to stop eating sweets or to exercise because her joints hurt. Are there any peptides that you know of that might help her with weight/sugar/healing that are not a glp1?
@Hammertime65 Do we think the vision was was due to diet? A high-sugar diet causes vision loss primarily by driving up blood glucose levels, leading to diabetes-related eye diseases like diabetic retinopathy, which damages retinal blood vessels. Chronic high sugar consumption also increases risks of glaucoma, cataracts, and macular degeneration.
If so, then diet is numero uno on that to-do list.
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@Hammertime65 Do we think the vision was was due to diet? A high-sugar diet causes vision loss primarily by driving up blood glucose levels, leading to diabetes-related eye diseases like diabetic retinopathy, which damages retinal blood vessels. Chronic high sugar consumption also increases risks of glaucoma, cataracts, and macular degeneration.
If so, then diet is numero uno on that to-do list.
@gym.rat I think it is the high sugar, but it didn't get real bad until she started the glp1, so that gets the blame. I've been trying for years to get her to go low carb but she's an addict to sugar.
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Thanks everyone for the suggestions. I will research the suggestions more. Diet talk goes in one ear and out the other. That has been her life long addiction. I can only harp so much. She knows it's bad for her. So maybe I can try these other things and get her feeling better and more hopeful.
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@hammertime65. Sorry for you and your family’s loss. About 4 years ago a med spa prescribed a Semaglutide from a Compounding pharmacy. It greatly reduced my craving for sugar. I used to love extra frosting on everything. Now I scrape frosting off of my few bites of a baked goodie. Now 4 weeks into my triz research, sweets don’t taste as good. Maybe a consult with a good peptide physician? The bad side is if your mom doesn’t want to change, then she can eat through the feeling of being full. It’s a mental thing along with the physical advantage of GLPs. Good luck with all of it
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Is she diabetic? Or pre diabetic? Do you know her HbA1c?
I am a diabetic - and there’s a few things I’ve learnt that are probably relevant here.- High blood sugars 100% effects your vision - dropping my A1c by a couple of points also lowered the strength of the prescription glasses I need to wear by several levels. It is noticeable - very.
- Before I started Reta I was on 2 types of insulin (4X a day/28 times a week) Metformin twice a day & Jardiance twice a day so 28X injections & 21 tablets a week.
Within 3 weeks I dropped ALL the insulin and pills and my glucose leveled are better than they have ever been since I started.
All with 1X injection of Reta a week.
It 100% drops sugar levels. - Even on smaller doses (maybe start at 1-2mg and maybe split into 2 injections a week) will stop her even thinking about eating lollies, chocolates, etc - not that she can’t if she wants to but she just won’t even think about them.
- The weight loss side of it I actually see as secondary but I won’t knock it back and no doubt will your mum.
There are a few other benefits to also apart from the actual weight loss side of it which is what most people use if for but i’ have to write an essay here to go through & explain it all (although I will expand a bit if you want)
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Is she diabetic? Or pre diabetic? Do you know her HbA1c?
I am a diabetic - and there’s a few things I’ve learnt that are probably relevant here.- High blood sugars 100% effects your vision - dropping my A1c by a couple of points also lowered the strength of the prescription glasses I need to wear by several levels. It is noticeable - very.
- Before I started Reta I was on 2 types of insulin (4X a day/28 times a week) Metformin twice a day & Jardiance twice a day so 28X injections & 21 tablets a week.
Within 3 weeks I dropped ALL the insulin and pills and my glucose leveled are better than they have ever been since I started.
All with 1X injection of Reta a week.
It 100% drops sugar levels. - Even on smaller doses (maybe start at 1-2mg and maybe split into 2 injections a week) will stop her even thinking about eating lollies, chocolates, etc - not that she can’t if she wants to but she just won’t even think about them.
- The weight loss side of it I actually see as secondary but I won’t knock it back and no doubt will your mum.
There are a few other benefits to also apart from the actual weight loss side of it which is what most people use if for but i’ have to write an essay here to go through & explain it all (although I will expand a bit if you want)
@STATIEEIGHT Thank you for the info. Her a1c on ozempic was 5.2. Now it is 6.8. She is on a new drug--rybelius? She doesn't use insulin. She tried metformin but kept crapping her pants, so that's a no go.
I forgot to mention, she had a cancerous breast lump removed last year also. So I'll have to figure out if the peps suggested will be a problem with that.
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Is she diabetic? Or pre diabetic? Do you know her HbA1c?
I am a diabetic - and there’s a few things I’ve learnt that are probably relevant here.- High blood sugars 100% effects your vision - dropping my A1c by a couple of points also lowered the strength of the prescription glasses I need to wear by several levels. It is noticeable - very.
- Before I started Reta I was on 2 types of insulin (4X a day/28 times a week) Metformin twice a day & Jardiance twice a day so 28X injections & 21 tablets a week.
Within 3 weeks I dropped ALL the insulin and pills and my glucose leveled are better than they have ever been since I started.
All with 1X injection of Reta a week.
It 100% drops sugar levels. - Even on smaller doses (maybe start at 1-2mg and maybe split into 2 injections a week) will stop her even thinking about eating lollies, chocolates, etc - not that she can’t if she wants to but she just won’t even think about them.
- The weight loss side of it I actually see as secondary but I won’t knock it back and no doubt will your mum.
There are a few other benefits to also apart from the actual weight loss side of it which is what most people use if for but i’ have to write an essay here to go through & explain it all (although I will expand a bit if you want)
@STATIEEIGHT the side effect of not wanting any of the bad vices you otherwise had is spooky. like its almost a autopilot mode. or taking the video game off survival mode. you have so much more mental bandwidth to do other shit or think of it in the first place.
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@STATIEEIGHT the side effect of not wanting any of the bad vices you otherwise had is spooky. like its almost a autopilot mode. or taking the video game off survival mode. you have so much more mental bandwidth to do other shit or think of it in the first place.
Pretty much.
I know a few diabetics now both T1’s & T2’s that are totally off all meds now with Reta.
One is a 25yo female friend of the family who is skinny as a rake - diagnosed as T1 at about 6-7yo totally off all meds/insulin as well using just Reta - pretty life changing stuff really. -
@STATIEEIGHT Thank you for the info. Her a1c on ozempic was 5.2. Now it is 6.8. She is on a new drug--rybelius? She doesn't use insulin. She tried metformin but kept crapping her pants, so that's a no go.
I forgot to mention, she had a cancerous breast lump removed last year also. So I'll have to figure out if the peps suggested will be a problem with that.
@Hammertime65
I have no experience with Rybelius but I thought it was just an oral GLP1 anyway?
Maybe they need to up the dosage on that to help her with the sugar carb addiction.5.1 is pretty good- 6.8 not so much.
Im a grumpy old bastard set in my own ways too so I sorta know what your dealing with but I’ve been on a bit of a mish mash carnivore/keto type diet for years and it works but Reta works better.Good luck with her
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Pretty much.
I know a few diabetics now both T1’s & T2’s that are totally off all meds now with Reta.
One is a 25yo female friend of the family who is skinny as a rake - diagnosed as T1 at about 6-7yo totally off all meds/insulin as well using just Reta - pretty life changing stuff really.@STATIEEIGHT yeah its slowly recruiting researchers amongst my circle of people as well. eventually everyone will be
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@quicksilver80 not sure if you mean that (comment about addictive behaviors) in a good or bad way. That being said, I agree with you. It is interesting looking at it from a moral perspective, taking a shot that makes you lose interest in all the bad stuff you’ve been trying to stop doing.
I expect that over the next few years, GLP-1’s will be widely used for every kind of addiction to help people quit and/or stay off of them.
The problem will remain: what productive things are there to do. Apparently one problem with GLP-1’s is that many people who identify being fat or ‘not able to’ do things because of obesity become very depressed when they lose a lot of weight because all the problems they had are still there and losing weight didn’t fix them.
Every day that I wake up is further evidence of my immortality.
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@quicksilver80 not sure if you mean that (comment about addictive behaviors) in a good or bad way. That being said, I agree with you. It is interesting looking at it from a moral perspective, taking a shot that makes you lose interest in all the bad stuff you’ve been trying to stop doing.
I expect that over the next few years, GLP-1’s will be widely used for every kind of addiction to help people quit and/or stay off of them.
The problem will remain: what productive things are there to do. Apparently one problem with GLP-1’s is that many people who identify being fat or ‘not able to’ do things because of obesity become very depressed when they lose a lot of weight because all the problems they had are still there and losing weight didn’t fix them.
@ResearchCat i mean its good of course. i know one who couldnt stay off the powder and out of massage parlors. and apparently it helps them. if it works it works.
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