Energy Peptides Question
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My rat is also feeling depleted after 1.5mo of R and starts strength training this week. MOTS-C is in the freezer but I’m reading wildly varying dosing from .5mg/daily to 5mg twice a week. Thoughts on where to start and end up? His work schedule involves traveling for 1 week every other week which currently makes it impossible to research on those weeks.
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My rat is also feeling depleted after 1.5mo of R and starts strength training this week. MOTS-C is in the freezer but I’m reading wildly varying dosing from .5mg/daily to 5mg twice a week. Thoughts on where to start and end up? His work schedule involves traveling for 1 week every other week which currently makes it impossible to research on those weeks.
My rat is also feeling depleted after 1.5mo of R and starts strength training this week. MOTS-C is in the freezer but I’m reading wildly varying dosing from .5mg/daily to 5mg twice a week. Thoughts on where to start and end up? His work schedule involves traveling for 1 week every other week which currently makes it impossible to research on those weeks.
When I did MOTS-c I started at 5mg week, split into 3 injections, to test for any reactions. After a few weeks I went to 10mg a week, split into 3 injections
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@brandenscheidecker said:
hell no give him something that works lol once a week IM will change his life.
At his age of 67, absolutely. Going from very low T to pinning 100mg/week and pushing your T into the 600 to 900 range will be a drastic improvement in energy and overall quality of life. Expect fat loss, muscle gain, improvements in sleep, blood pressure, and glucose measurements as well. There is a reason why TRT is so popular.
Many go on TRT way to early in life when lifestyle changes can improve T levels drastically. However that's generally true for younger men. Once you're above 60, those leydig cells that produce testosterone just aren't as responsive as we need them to be.
The problem all goes back to mitochondria. The smooth endoplasmic reticulum is responsible for converting upstream hormones like pregnenolone into various andro metabolites that break down into testosterone, but the mitochondria are all dysfunctional which is essentially a broken chain in this process.
The current crop of peptide drugs do help energize existing mitochondria and even regrow new ones, but they are essentially the first gen and aren't effective enough to replace and regrow enough to be effective in this process for seniors who have a lot of mitochondria dysfunction. We do see increases in testosterone from using these drugs, however it's generally in younger people and/or only a small amount.
When this process is refined and we get 2nd/3rd gen drugs that do this effectively, replacing testosterone won't even be necessary any more for most people, because the mitochondria will be put back to work again and this process will holistically work again.
@brandenscheidecker said:
hell no give him something that works lol once a week IM will change his life.
At his age of 67, absolutely. Going from very low T to pinning 100mg/week and pushing your T into the 600 to 900 range will be a drastic improvement in energy and overall quality of life. Expect fat loss, muscle gain, improvements in sleep, blood pressure, and glucose measurements as well. There is a reason why TRT is so popular.
Many go on TRT way to early in life when lifestyle changes can improve T levels drastically. However that's generally true for younger men. Once you're above 60, those leydig cells that produce testosterone just aren't as responsive as we need them to be.
The problem all goes back to mitochondria. The smooth endoplasmic reticulum is responsible for converting upstream hormones like pregnenolone into various andro metabolites that break down into testosterone, but the mitochondria are all dysfunctional which is essentially a broken chain in this process.
The current crop of peptide drugs do help energize existing mitochondria and even regrow new ones, but they are essentially the first gen and aren't effective enough to replace and regrow enough to be effective in this process for seniors who have a lot of mitochondria dysfunction. We do see increases in testosterone from using these drugs, however it's generally in younger people and/or only a small amount.
When this process is refined and we get 2nd/3rd gen drugs that do this effectively, replacing testosterone won't even be necessary any more for most people, because the mitochondria will be put back to work again and this process will holistically work again.
We got his testosterone level. It was 442. Now, to
Convince the Doctor he heeds 600-900 -
@brandenscheidecker said:
hell no give him something that works lol once a week IM will change his life.
At his age of 67, absolutely. Going from very low T to pinning 100mg/week and pushing your T into the 600 to 900 range will be a drastic improvement in energy and overall quality of life. Expect fat loss, muscle gain, improvements in sleep, blood pressure, and glucose measurements as well. There is a reason why TRT is so popular.
Many go on TRT way to early in life when lifestyle changes can improve T levels drastically. However that's generally true for younger men. Once you're above 60, those leydig cells that produce testosterone just aren't as responsive as we need them to be.
The problem all goes back to mitochondria. The smooth endoplasmic reticulum is responsible for converting upstream hormones like pregnenolone into various andro metabolites that break down into testosterone, but the mitochondria are all dysfunctional which is essentially a broken chain in this process.
The current crop of peptide drugs do help energize existing mitochondria and even regrow new ones, but they are essentially the first gen and aren't effective enough to replace and regrow enough to be effective in this process for seniors who have a lot of mitochondria dysfunction. We do see increases in testosterone from using these drugs, however it's generally in younger people and/or only a small amount.
When this process is refined and we get 2nd/3rd gen drugs that do this effectively, replacing testosterone won't even be necessary any more for most people, because the mitochondria will be put back to work again and this process will holistically work again.
We got his testosterone level. It was 442. Now, to
Convince the Doctor he heeds 600-900@jackiew1 said:
.
We got his testosterone level. It was 442. Now, to
Convince the Doctor he heeds 600-900Surprisingly not bad for his age. What was his IGF-1? Did they test DHEA?
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Just seeing this thread today. Good discussion. Thanks! I am 58, last T test was 399, which is bottom of ‘normal’. Not really what I want to talk about here. I am specifically not interested in TRT unless I get a sign that it is a problem, which it doesn’t seem to be. I could just be an idiot.
What I want to talk about is how completely useless most PCP’s and the the medical industrial complex is. I have been saying for decades - partly of self-delusion and partly because it is the only way to describe it - that I am an operational athlete(yeah, I stole that from the old Teams guys). I am going to keep lifting, fighting, moving, etc. Your job is to treat me so I can continue. But that isn’t what doctors do. Doctors keep sick people alive. They don’t help healthy people optimize. If you find a doctor who does this (probably why we all fanboy/girl over Dr. Froeze) never let them go.
I am going through one of those periods where I see a bunch of doctors for various things and it is remarkable that you can go to your PCP, an ortho, and other people with your body bruised black from your spine to your ankle and have them remark that it must be quite painful.
Anyway, MOTS-C is a great addition to your stack for energy, particularly increasing exercise capacity.
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Just seeing this thread today. Good discussion. Thanks! I am 58, last T test was 399, which is bottom of ‘normal’. Not really what I want to talk about here. I am specifically not interested in TRT unless I get a sign that it is a problem, which it doesn’t seem to be. I could just be an idiot.
What I want to talk about is how completely useless most PCP’s and the the medical industrial complex is. I have been saying for decades - partly of self-delusion and partly because it is the only way to describe it - that I am an operational athlete(yeah, I stole that from the old Teams guys). I am going to keep lifting, fighting, moving, etc. Your job is to treat me so I can continue. But that isn’t what doctors do. Doctors keep sick people alive. They don’t help healthy people optimize. If you find a doctor who does this (probably why we all fanboy/girl over Dr. Froeze) never let them go.
I am going through one of those periods where I see a bunch of doctors for various things and it is remarkable that you can go to your PCP, an ortho, and other people with your body bruised black from your spine to your ankle and have them remark that it must be quite painful.
Anyway, MOTS-C is a great addition to your stack for energy, particularly increasing exercise capacity.
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@jackiew1
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If you don’t want to do TRT, HCG is a great alternative and works great with MOTS-C.
Just food for thought@Commander My understanding of HCG is that its a great support tool if you are on TRT. If you're not on TRT, I would look at Kisspeptin personally. Maybe even Testagen or stack Testagen with Kisspeptin. The thing with Testagen is that I have anecdotal evidence on both sides of the spectrum and nothing in the middle. That always leaves me suspicious.
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Yes run MOTSC, NAD+ and SS-31. You can also suppliment Co Q10 and Methylin blue. My daily go to. As soon as he is back on his feet and wants to level up def add 5amino 1mq + AOD or Slu-pp-322 on the stack. Believe or not, even Semax has given me a boost along a double latte.
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