The quest for better sleep
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Going to do a little journal for myself in my quest for better sleep and others are welcome to follow along or ask questions as I go. Since starting Reta my sleep has been terrible. The increase in resting heart rate has made me restless and I do a ton of tossing and turning. Just ruined my sleep. Started CJC no DAC / IPA about 3 weeks later thinking this would help and I think it actually made it worse. Not sure which pep or why, but I've got some very very minor tinnitus now. More noticeable while laying down. This has also affected my sleep. Lastly, even if I get to sleep, I'm waking up, having to pee in the middle of the night, or more tossing and turning because I just can't get comfortable.
Solutions: I was on magnesium supplements before all of this and it really helped to get me to sleep. I struggle with a racing mind at times. I've also dabbled in melatonin and that helps for the most part, but I rarely take this. Limiting blue light has not helped at all. Putting on a podcast has helped turn off my mind and get to sleep. It's worth noting that I take the magnesium every night before bed, but once I started Reta it seems to have become less ineffective, but the main problem for me is the quality of sleep and the constant waking up.
Peptides: First tried Pinealon. Made that into a nasal. I like the nasal options because I get needle fatigue and frankly its just way more convenient. Bought it from Mile High Compounds and dosed it every single night for about 12-14 days. If it did anything, it did very little. I will not be buying this again. One side effect I think I would attribute to the nasal Pinealon is waking up with a minor headache. Not every morning, but most mornings. I was taking this at night before bed. Then one night I took it about 3 hours before bed and I think this helped. I only did this one time however. Perhaps if I did this more I would have gotten better results. Then I came across some info that you should dose it in the morning right after you wake up. I tried that, but was honestly way too inconsistent and would forget. I'm not sure it helped anyway. Point being I think I'm over this one. Maybe I'll try subq down the road.
Next up, DSIP. Made it into a nasal. I take two sprays up each nostril about 30min before bed. Dosing is around 400mcg total. Night 1 I noticed improvement, but had to get up early so only got 6 hours of sleep, but I felt better than I had been in terms of sleep quality. I don't recall any vivid dreams as people talk about. I was cautiously optimistic this pep was working. Night 2, last night, was even better. Once I fell asleep I stayed asleep. Woke up feeling rested on just 7 hours of sleep. Probably the best sleep I've had in weeks. This time I had vivid dreams that I would describe as normal. I've come across evidence that you can become desensitized to DSIP, thus it's important to do 3-4 nights on, 2-3 off, so I'm going to follow this protocol. Hopefully I'm on the right track and the positive results continue. I'm heading to Scottsdale for a mini vacation this Wednesday. Upon my return I'm excited to start my Epitalon research. I've heard lots of positive anecdotes about it improving sleep quality. I will continue DSIP while on Epitalon and report back results.
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I have also been researching with Reta/DSIP/CJC no DAC / IPA. Sleep definitely improved with DSIP (5 on 2 off) in that when I do wake, I fall asleep back right away. My mind would race before when I woke. I still wake about twice a night to go. I've just accepted that as it is what it is. I'm at 300mcg. Oh and the vivid dreams have been a thing for me also.
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My rat is on Reta and started CJC no DAC/IPA about 4 weeks after starting Reta. No sleep issues with Reta but the CJC/IPA did affect my poor little rats sleep. I moved the CJC/IPA dose from night time before bed to a morning dose and not feeding my rat for at least two hours after the morning dose. My rats sleeping habits seem to have gotten better since trying this.
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Try cutting your Reta dosage in half, seems like you're super sensitive to it. Move your CJC/IPA to morning dosage. I have noticed that I sleep better on CJC cycle despite it being in the a.m., so there is carry over into the night.
Magnesium does pull water into the colon/digestive system, and can lead to more frequent urination up to a few hours after taking it. If you're taking magnesium at night, this can lead lead to more frequent nighttime urination. Take your magnesium during the day.
Switch to glycine at night. This helps actually prevent nighttime urination. Stop fluids at least 2 hours before bed (small amount to take supps is ok).
Room should be as dark as possible. Temperature should be cool, a hot room will disrupt sleep. Don't eat too close to bed. White noise helps. No caffeine after 12pm. I eat dinner early, and I'd advise you to as well.
My nighttime sleep stack is
Glycine 1g
L Theanine 200mg
5 htp 50mgSubtle, cheap and effective. I do all of the above. I also don't worry about it. If I don't sleep well for whatever reason, I'll be fine and deal with it and try and catch up the next day.
I don't sleep well if I go too deep into a calorie deficit, and that might be why you're having issues with the Reta.
If you continue to have issues after trying the above, cut the Reta off completely and see if that helps. You might be a hyper responder to GLP drugs. I get that GLPS are a lifesaver to many and certainly obesity is a issue. Perhaps consider switching to a single agonist GLP like Semaglutide at a very low dosage, that will definitely mitigate side effects like sleep issues.
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@neil-mccauley can you elaborate on HTP?
Founds some info, I hadn't heard of this before, sounds very beneficial for more than just sleep, going to give it a try
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@neil-mccauley can you elaborate on HTP?
Founds some info, I hadn't heard of this before, sounds very beneficial for more than just sleep, going to give it a try
@neil-mccauley can you elaborate on HTP?
Founds some info, I hadn't heard of this before, sounds very beneficial for more than just sleep, going to give it a try
It's 5-Htp. Great bang for your buck supplement and just a good all around thing to take. I use 50mg at night. Increases natural production of serotonin and melatonin, but does both indirectly and doesn't interrupt your natural process, just supports it in a holistic manner. Zero side effects at that dosage.
Higher dosages taken throughout the day can slightly tamper down hunger, although I have never used it for that before.
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CJC no DAC / IPA drop this and go to HGH
@brandenscheidecker Not ready for that yet. Plus there might still be kids in my future. Maybe when I get into my 50s.
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Try cutting your Reta dosage in half, seems like you're super sensitive to it. Move your CJC/IPA to morning dosage. I have noticed that I sleep better on CJC cycle despite it being in the a.m., so there is carry over into the night.
Magnesium does pull water into the colon/digestive system, and can lead to more frequent urination up to a few hours after taking it. If you're taking magnesium at night, this can lead lead to more frequent nighttime urination. Take your magnesium during the day.
Switch to glycine at night. This helps actually prevent nighttime urination. Stop fluids at least 2 hours before bed (small amount to take supps is ok).
Room should be as dark as possible. Temperature should be cool, a hot room will disrupt sleep. Don't eat too close to bed. White noise helps. No caffeine after 12pm. I eat dinner early, and I'd advise you to as well.
My nighttime sleep stack is
Glycine 1g
L Theanine 200mg
5 htp 50mgSubtle, cheap and effective. I do all of the above. I also don't worry about it. If I don't sleep well for whatever reason, I'll be fine and deal with it and try and catch up the next day.
I don't sleep well if I go too deep into a calorie deficit, and that might be why you're having issues with the Reta.
If you continue to have issues after trying the above, cut the Reta off completely and see if that helps. You might be a hyper responder to GLP drugs. I get that GLPS are a lifesaver to many and certainly obesity is a issue. Perhaps consider switching to a single agonist GLP like Semaglutide at a very low dosage, that will definitely mitigate side effects like sleep issues.
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Scientologists, use a supplement called Cal-Mag (calcium, magnesium blend) that helps promote sleep. I tried it a few times many years ago when they tried to indoctrinate me into there cult. It definitely works.
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I’m on 5mg Reta 2x per week (10 total) and it has definitely negatively impacted sleep due to increase in RHR and lower HRV. What has worked for me is this product https://getumbo.com/pages/myco-rest-special?srsltid=AfmBOoqUUJhCLvLVSNzWYlY_YlwZUobFxs6Nhmho7Z5t79q9D6q761uC and 10mg doxepin (prescription but cheap)
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Honestly, I think my lifestyle changes have helped a lot. I didn’t fine GHRH or epitalon to help a lot with sleep. But I go to bed early(10-10:30) use sleep focus, don’t eat or drink booze for a couple hours before sleep, and aside from getting up for the bathroom too much, I am sleeping a lot better.
A side effect of GLP-1’s is that I eat and drink less at night so I have no reflux and my sleep has much improved. I do still have odd nights where i do not sleep well, or at all. But I am sleeping better than in decades.
I hope you figure it out.
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I’m going on week 5 of HGH. I tried every other peptide. Tesamorelin cjc, etc. nothing is like GH. No more waking up at 49 like, did I run a marathon yesterday? I’m going to say it’s not cheap. But it is worth it. I can’t explain how much it’s worth it.
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Try cutting your Reta dosage in half, seems like you're super sensitive to it. Move your CJC/IPA to morning dosage. I have noticed that I sleep better on CJC cycle despite it being in the a.m., so there is carry over into the night.
Magnesium does pull water into the colon/digestive system, and can lead to more frequent urination up to a few hours after taking it. If you're taking magnesium at night, this can lead lead to more frequent nighttime urination. Take your magnesium during the day.
Switch to glycine at night. This helps actually prevent nighttime urination. Stop fluids at least 2 hours before bed (small amount to take supps is ok).
Room should be as dark as possible. Temperature should be cool, a hot room will disrupt sleep. Don't eat too close to bed. White noise helps. No caffeine after 12pm. I eat dinner early, and I'd advise you to as well.
My nighttime sleep stack is
Glycine 1g
L Theanine 200mg
5 htp 50mgSubtle, cheap and effective. I do all of the above. I also don't worry about it. If I don't sleep well for whatever reason, I'll be fine and deal with it and try and catch up the next day.
I don't sleep well if I go too deep into a calorie deficit, and that might be why you're having issues with the Reta.
If you continue to have issues after trying the above, cut the Reta off completely and see if that helps. You might be a hyper responder to GLP drugs. I get that GLPS are a lifesaver to many and certainly obesity is a issue. Perhaps consider switching to a single agonist GLP like Semaglutide at a very low dosage, that will definitely mitigate side effects like sleep issues.
I don't sleep well if I go too deep into a calorie deficit, and that might be why you're having issues with the Reta.
Yes that's largely why. Its a blood sugar crash in the middle of the night on Reta which is causing the disrupted sleep. The issue is then compounded when you're needing to take a GHRH agonist on an empty stomach which can take 3-4hrs for gastric emptying on Reta which means your CJC/IPA dose is best on an empty stomach....
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I’m going on week 5 of HGH. I tried every other peptide. Tesamorelin cjc, etc. nothing is like GH. No more waking up at 49 like, did I run a marathon yesterday? I’m going to say it’s not cheap. But it is worth it. I can’t explain how much it’s worth it.
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Took a 4 day break from all peps while on vacation in Scottsdale and slept decently well. Came back last night and I only continued my nasal DSIP. Ended up sleeping great and for a full 8 hours which has been very problematic. Felt refreshed all day. This evening I just gave my rat 1mg Epitalon and will take DSIP nasal again.
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I don't sleep well if I go too deep into a calorie deficit, and that might be why you're having issues with the Reta.
Yes that's largely why. Its a blood sugar crash in the middle of the night on Reta which is causing the disrupted sleep. The issue is then compounded when you're needing to take a GHRH agonist on an empty stomach which can take 3-4hrs for gastric emptying on Reta which means your CJC/IPA dose is best on an empty stomach....
I don't sleep well if I go too deep into a calorie deficit, and that might be why you're having issues with the Reta.
Yes that's largely why. Its a blood sugar crash in the middle of the night on Reta which is causing the disrupted sleep. The issue is then compounded when you're needing to take a GHRH agonist on an empty stomach which can take 3-4hrs for gastric emptying on Reta which means your CJC/IPA dose is best on an empty stomach....
I pin my GH secretagogues in the a.m. first thing so I never have to worry about what state of fasting I am in.
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Okay....wow....whoever on this forum in another thread wrote about taking Epitalon right before bed was right. 30 minutes after the pin and I thought I was going to sleep standing up like Mr. Ed. Laid down and couldn't keep my eyes open. Great sleep on night one and it was paired with nasal DSIP. I did feel a bit groggy getting up for work and honestly wanted to turn right back over and keep sleeping. I also took a 1.5 hour nap after work which is unusual. Will be something to monitor.
Also worth noting that I pinned a half dose of Reta (1mg) about two hours before which usually gets my heart going. I did this because I missed a week due to travels. I plan to pin another 1mg on Thursday to keep with my normal 2mg weekly dosing.
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Crazy, I've been recently looking into sleep aids as well. My wearable has been telling me I've been getting poor sleep. I had been taking Magnesium Glycinate as it can help, and help you being regular, which I am, start grinding my coffee in the morning and gotta go. But I recently tried L-Theanine. I did get better sleep but I was grogy when I got up the next day, it went away after 30-45min of being up. Reading all these posts must be the reta, currently at 1mg weekly. About to start 2mg. Will have to see the diff. I have Epitalon on my list, but many of the peps say possible - "active cancer contraindications" which has me a little concerned. I don't currenly have any, but have had some cut out before.
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Crazy, I've been recently looking into sleep aids as well. My wearable has been telling me I've been getting poor sleep. I had been taking Magnesium Glycinate as it can help, and help you being regular, which I am, start grinding my coffee in the morning and gotta go. But I recently tried L-Theanine. I did get better sleep but I was grogy when I got up the next day, it went away after 30-45min of being up. Reading all these posts must be the reta, currently at 1mg weekly. About to start 2mg. Will have to see the diff. I have Epitalon on my list, but many of the peps say possible - "active cancer contraindications" which has me a little concerned. I don't currenly have any, but have had some cut out before.
@damic I'm no doctor, but per Grok there is no link to cancer and Epitalon. In fact it sounds more anti cancer. I read a ton about peptides and collect massive amounts of anecdotal evidence as a data point in a web app that I've built and I've yet to see cancer and Epitalon linked.
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