Testing Results Showed Arsenic and Lead
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I recently had 7 peptides tested from a 3rd party and 3 of the peptides popped for arsenic and lead. The metal levels are within commonly accepted pharmaceutical elemental impurity limits and would generally be considered low-risk from a heavy metals standpoint. But, I need some feedback from others on this. A lot of companies aren't even testing for heavy metals!
Arsenic
GHK-Cu: 0.60 µg/vial
TB-500: 0.56 µg/vial
Retatrutide: 0.53 µg/vial
MOTS-c: 0.51 µg/vialLead
GHK-Cu: 0.91 µg/vial -
@jackiew1 I have a suppler in China...just like everyone else.
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@jackiew1 I have a suppler in China...just like everyone else.
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@jackiew1 I have a suppler in China...just like everyone else.
Most, yes, but there are quite a few people here that also buy from US based suppliers
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I don't mean that they make it here in the US. I meant that they source it from a US based vendor. There are MANY on here that we buy from. There are many listed on this website as vendors. It ships from the US, but of course it came from China. I was wondering who you purchased it from.
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https://youtu.be/TOlX5ezVCuQ?si=cL49imstjxynAvYZ
This was posted earlier but relevant here as well. It's an interview with Peter Magic, owner of Janoshik. A lot of good info, but one of the questions was on this very topic. Heavy metals and testing. He said (paraphrasing) "i'd be happy to test for heavy metals and glad to take someone's money, but almost every surface you test will test positive for it, at some level, but always well below anything that would cause harm to humans." So, take a moment to watch it. Very good info, and maybe helpful here as well.
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@jackiew1 I have a suppler in China...just like everyone else.
@keithvanderhoeven Care to share the source name/batch number in case anyone else might have the same stuff?
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@markgroce thanks for sharing that video, 27:35 is where Peter talks about testing for heavy metals and endotoxins. I was interested to hear his claim that anything will test positive for heavy metals, and his thoughts on endotoxin testing.
@keithvanderhoeven I'm getting some signal that those levels are not concerning:
The United States Pharmacopeial Convention (USP) has established the daily parenteral limit for arsenic at 15 μg/day. Apparently the European standard is exactly the same.
If you plan to pin that reta over 4 doses, you'll get 0.13 μg in each dose. As I understand it, a serving rice in the US has 2-7 μg of arsenic.
Sources:
- https://www.usp.org/sites/default/files/usp/document/our-work/chemical-medicines/key-issues/232-40-35-1s.pdf, table 1, page 2.
- https://www.ema.europa.eu/en/documents/scientific-guideline/international-conference-harmonisation-technical-requirements-registration-pharmaceuticals-human-use-ich-q3d-elemental-impurities-step-5-revision-1_en.pdf, page 30
Oh, and I had no idea what "parenteral" means, so I had to look that up:
Administered or occurring elsewhere in the body than the mouth and alimentary canal.
Origin: para: "beside" + enteron "intestine" + al. -
@markgroce thanks for sharing that video, 27:35 is where Peter talks about testing for heavy metals and endotoxins. I was interested to hear his claim that anything will test positive for heavy metals, and his thoughts on endotoxin testing.
@keithvanderhoeven I'm getting some signal that those levels are not concerning:
The United States Pharmacopeial Convention (USP) has established the daily parenteral limit for arsenic at 15 μg/day. Apparently the European standard is exactly the same.
If you plan to pin that reta over 4 doses, you'll get 0.13 μg in each dose. As I understand it, a serving rice in the US has 2-7 μg of arsenic.
Sources:
- https://www.usp.org/sites/default/files/usp/document/our-work/chemical-medicines/key-issues/232-40-35-1s.pdf, table 1, page 2.
- https://www.ema.europa.eu/en/documents/scientific-guideline/international-conference-harmonisation-technical-requirements-registration-pharmaceuticals-human-use-ich-q3d-elemental-impurities-step-5-revision-1_en.pdf, page 30
Oh, and I had no idea what "parenteral" means, so I had to look that up:
Administered or occurring elsewhere in the body than the mouth and alimentary canal.
Origin: para: "beside" + enteron "intestine" + al.@glpbacon I found the same intel. It appears a lot of peptide companies are forgoing the heavy metals testing because they will "pop" and the levels are so low it doesn't cause a concern. I'm a transparent person and I want my customers to know what they are putting in their bodies!
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@jackiew1 There are no US based suppliers! And if there were they aren't testing for heavy metals. Majority of peptide companies are only testing purity, endotoxins and vial strength/potencey.
@keithvanderhoeven This isn't true. Many have extended their testing and do heavy metals. It all depends on your source and of course the amount of heavy metals. I've come across stuff that says heavy metals are everywhere including our food and its impossible to avoid b/c of the soil. I have no idea how true this is, but I tend to believe it.
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https://youtu.be/TOlX5ezVCuQ?si=cL49imstjxynAvYZ
This was posted earlier but relevant here as well. It's an interview with Peter Magic, owner of Janoshik. A lot of good info, but one of the questions was on this very topic. Heavy metals and testing. He said (paraphrasing) "i'd be happy to test for heavy metals and glad to take someone's money, but almost every surface you test will test positive for it, at some level, but always well below anything that would cause harm to humans." So, take a moment to watch it. Very good info, and maybe helpful here as well.
@markgroce I thought this was great. Lots to unwrap. Basically said sterility and quantity is all you need to test; everything else is a waste, other than comparison testing. That was my takeaway. He said endotoxins is a total waste of money but he does it for some customers.
The best was on sterile water v BAC he essentially said BAC is a waste that bacteria can't grow without dirt, and that if you keep the needle clean, sterile water is better because there is a lower chance of injection site reaction. He said he has had sterile water for 12 years and it's still fine nothing can grow in it unless you introduce dirt.
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@markgroce I thought this was great. Lots to unwrap. Basically said sterility and quantity is all you need to test; everything else is a waste, other than comparison testing. That was my takeaway. He said endotoxins is a total waste of money but he does it for some customers.
The best was on sterile water v BAC he essentially said BAC is a waste that bacteria can't grow without dirt, and that if you keep the needle clean, sterile water is better because there is a lower chance of injection site reaction. He said he has had sterile water for 12 years and it's still fine nothing can grow in it unless you introduce dirt.
@markgroce I thought this was great. Lots to unwrap. Basically said sterility and quantity is all you need to test; everything else is a waste, other than comparison testing. That was my takeaway. He said endotoxins is a total waste of money but he does it for some customers.
The best was on sterile water v BAC he essentially said BAC is a waste that bacteria can't grow without dirt, and that if you keep the needle clean, sterile water is better because there is a lower chance of injection site reaction. He said he has had sterile water for 12 years and it's still fine nothing can grow in it unless you introduce dirt.
He's not completely wrong (I don't think). Sterility doesn't provide an environment for bacteria to grow, but doesn't mean they can't survive for some arbitrary amount of time within that environment. Hence the inclusion of the benzoyl alcohol. I have a year or 2 worth of bac. But, the FDA may force me to start making my own at some point!
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Pick your battles otherwise you'll be fighting constantly with everything. So many bigger fish to fry. Are you eating sugar? Seed Oils? Carbs? Food with anti-nutrients? Heavy metal testing of peptides is number one million on the list of things I care about. (I pay for a shtload of frequent blood and health testing so I DO care about things that matter)
You want something to care about? Do some research in regards to toxins in shrimp, crabs, lobsters and God forbid fish liver. Let me know when you absolutely avoid all of those and we can have a conversation.
You are welcome
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@markgroce I thought this was great. Lots to unwrap. Basically said sterility and quantity is all you need to test; everything else is a waste, other than comparison testing. That was my takeaway. He said endotoxins is a total waste of money but he does it for some customers.
The best was on sterile water v BAC he essentially said BAC is a waste that bacteria can't grow without dirt, and that if you keep the needle clean, sterile water is better because there is a lower chance of injection site reaction. He said he has had sterile water for 12 years and it's still fine nothing can grow in it unless you introduce dirt.
@Stevepep said:
Basically said sterility and quantity is all you need to test;Purity and quantity you mean? I watched it and then rewatched it and couldn't hear him reference sterility.
Overall I feel that the interview threw a large wet blanket on a lot of the fear mongering surrounding gray...thoughts?
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