Internal Logan's Run

[Stan Douglas]

FOXO4-DRI
5 day cycle: 10mg-off-5mg-off-final 5mg
Planning on repeating twice a year

What is your procedure and how does one even test for results?

[MacLeeezy]

@Stan-Douglas I’m going to start this Friday, and do an almost identical protocol with a grand total of 30mg. For funsies, I had my testosterone checked yesterday and I’m going to check it again in 6-8 weeks. In the mice studies it nearly doubled the test in old mice. Besides hair fullness and the potential to slow down graying hair I’m personally not sure how to test results.

According to Grok:
Practical Testing Approaches
Here are common methods users and clinicians in longevity contexts use or discuss:

1. Blood Biomarkers (Most Accessible):
   • Inflammation/SASP markers: hs-CRP, IL-6, TNF-α, IL-1β. Senolytics often aim to lower chronic “inflammaging.”
   • Senescence-related: p16^INK4a expression in peripheral blood T-cells (emerging biomarker), GDF-15, osteopontin, or other SASP factors. Some labs/research settings measure these. 
   • Hormones: Total/free testosterone (mouse data showed improvements in aged testes via reduced local senescence). Also consider IGF-1 or others.
   • General panels: Comprehensive metabolic panel, liver/kidney function (e.g., AST, creatinine), oxidative stress markers.
   • Timing: Baseline before a cycle, then 2–4 weeks after, and possibly 1–3 months later. Effects may take weeks to months to appear.

[hunt_ak]

I’m going to follow this protocol/stack according to some other info I found elsewhere. That said, I’ll subscribe to the ‘blood in blood out’ mantra of before/after bloodwork before I start.

Planning on doing this mid-month. The Fox is supposed to really make you feel poorly for a bit from what I gather