Two interesting articles on Survodutide recently published
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Survodutide in adults with obesity and metabolic dysfunction-associated steatotic liver disease: SYNCHRONIZE-MASLD, a randomized, double-blind, placebo-controlled phase 3 trial
https://www.nature.com/articles/s41591-026-04479-3and
Survodutide Once Weekly for the Treatment of Adults with Obesity
https://www.nejm.org/doi/full/10.1056/NEJMoa2600751Both published yesterday!
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Survodutide in adults with obesity and metabolic dysfunction-associated steatotic liver disease: SYNCHRONIZE-MASLD, a randomized, double-blind, placebo-controlled phase 3 trial
https://www.nature.com/articles/s41591-026-04479-3and
Survodutide Once Weekly for the Treatment of Adults with Obesity
https://www.nejm.org/doi/full/10.1056/NEJMoa2600751Both published yesterday!
@krisacero Summary please?
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@krisacero Summary please?
Sure! In the Nature Medicine one:
Survodutide titrating up to 6.0 mg was statistically superior to the placebo for reducing liver fat, body weight, and improving liver inflammation, fibrosis markers, and cardiometabolic health in people with obesity and at-risk MASLD (excess fat buildup in the liver). Reported a roughly 12% bodyweight loss but more significantly, focused a lot on removing fat from the liver.
In the NEJM one:
Survodutide delivered robust, sustained weight loss (12–16.6% roughly) superior to placebo in people with obesity without diabetes, with strong effects on fat depots (especially liver and visceral fat). -
Sure! In the Nature Medicine one:
Survodutide titrating up to 6.0 mg was statistically superior to the placebo for reducing liver fat, body weight, and improving liver inflammation, fibrosis markers, and cardiometabolic health in people with obesity and at-risk MASLD (excess fat buildup in the liver). Reported a roughly 12% bodyweight loss but more significantly, focused a lot on removing fat from the liver.
In the NEJM one:
Survodutide delivered robust, sustained weight loss (12–16.6% roughly) superior to placebo in people with obesity without diabetes, with strong effects on fat depots (especially liver and visceral fat).@krisacero Is there any write-up about Survo and Reta fat loss comparison? I know there's no head to head trial but have people studied the numbers independently and compared them?
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@krisacero Is there any write-up about Survo and Reta fat loss comparison? I know there's no head to head trial but have people studied the numbers independently and compared them?
@pep_researcher considering that these articles were published yesterday I don’t know if anyone’s done a comparison. I would assume with any of these studies, the scope is typically limited, like how the Nature article, where they do mention the weight loss, focused heavily on the decrease in fat in the liver especially.
I believe in the phase 3 study on Reta (which was what, a month ago?), they showed a much higher loss of body weight.
The reason I find these ones interesting more than some of the Reta ones are the food noise aspect as well as some of side effects of Reta which make me nervous. @randy mentions it in the “Ghetto Reta” stack using Tirz and Survo. In addition the mentions of the fatty liver remediation make me very excited for the future of these findings
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@pep_researcher considering that these articles were published yesterday I don’t know if anyone’s done a comparison. I would assume with any of these studies, the scope is typically limited, like how the Nature article, where they do mention the weight loss, focused heavily on the decrease in fat in the liver especially.
I believe in the phase 3 study on Reta (which was what, a month ago?), they showed a much higher loss of body weight.
The reason I find these ones interesting more than some of the Reta ones are the food noise aspect as well as some of side effects of Reta which make me nervous. @randy mentions it in the “Ghetto Reta” stack using Tirz and Survo. In addition the mentions of the fatty liver remediation make me very excited for the future of these findings
@krisacero Yeah I think the MASH results of Survodutide are better than Reta IIRC.
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Yeah, but here's another article published yesterday. Seems someone(s) want to possibly get rid of Survo:
https://www.cnbc.com/2026/06/08/weight-loss-drug-stock-zealand-pharma-data-ada.html
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