NAION as side effect from GLPs
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I have heard about increasing cases of NAION in patients using GLPs. Any data to look deeper?
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The study wasn’t really a study. They just evaluated medical coding data and looked at people who were written a Rx for sema, whether they took it or not. They also noted an error in their data collection stating “Our manual review of records for this study revealed that 40% of cases coded as ischemic optic neuropathy were not actually NAION but rather arteritic ischemic optic neuropathy from giant cell arteritis”.
https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2820255 -
Might be useful to spell it out so everyone knows what the hell you’re talking about. There have been a few threads on here about GLP-1’s causing blindness. The risk seems quite low and happens in the normal population as well. This happened to my sister in law about 15 years ago, where she lost partial vision in her eye. It has progressed to almost complete loss of vision. Doctors think it was due to ocular stroke but aren’t sure. Not much can be done after the fact.
To MyB’s point, if you are selecting a group of inactive, diabetic, overweight people - all comorbidities for this kind of thing - you have to eliminate all the other causes of the condition before you can attribute it to the GLP-1.
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The study wasn’t really a study. They just evaluated medical coding data and looked at people who were written a Rx for sema, whether they took it or not. They also noted an error in their data collection stating “Our manual review of records for this study revealed that 40% of cases coded as ischemic optic neuropathy were not actually NAION but rather arteritic ischemic optic neuropathy from giant cell arteritis”.
https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2820255@MyB I saw a potscat of Dr. David Sinclair and he mention this increasing side effect in population taking glps. So I start researching about it.
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This post is deleted!
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Might be useful to spell it out so everyone knows what the hell you’re talking about. There have been a few threads on here about GLP-1’s causing blindness. The risk seems quite low and happens in the normal population as well. This happened to my sister in law about 15 years ago, where she lost partial vision in her eye. It has progressed to almost complete loss of vision. Doctors think it was due to ocular stroke but aren’t sure. Not much can be done after the fact.
To MyB’s point, if you are selecting a group of inactive, diabetic, overweight people - all comorbidities for this kind of thing - you have to eliminate all the other causes of the condition before you can attribute it to the GLP-1.
@ResearchCat you are right! I tried to edit my post but couldn't
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FWIW, I didn’t mean for that to sound as snarky as it did. I meant it more in a funny way.
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Even among people with "normal" insulin functioning, shifts in blood sugar can affect eyesight. If someone is drastically decreasing their food and beverage intake while on GLP meds, they run more risk of experiencing dehydration, electrolyte imbalances, and nutritional deficiencies, all of which are linked to blurry vision, and statistically this population is also more likely to have been diabetic or pre-diabetic beforehand (a known high-risk factor for ocular problems). In studies where GLP/optic neuropathy links were demonstrated, all the potentially overlapping co-morbidities make it difficult to say whether the connection is causational or correlational. I will certainly be watching carefully as further data gets collected, but lots of users report improved sight since starting sema and tirz, likely due to better-controlled blood sugar.
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I think when youre trying to remedy a very wide range of issues with one drug and often times its being used as a last ditch effort to save peoples lives. You see these wild 5 percent chance issues. Like how many people over 350 pounds were going to lose their eyesight anyways? And how many were gonna get their legs amputated if they kept pushing it. I think once we accept that reality we will have a better grasp of what different categories of people get. And how to manage the sides as much as manage the initial problem.
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