Study: RUO Reta Underperformed Lilly's Trials
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Most of the people posting online are taking way less than the doses Lilly is giving participants in the trials. It is very common to see people posting that they are taking 0.5mg-6mg. In the trials they start at 2mg and titrate up to 12mg by the 17th week. A lot of users online seem to be people who aren't even obese as well so they have much less to lose.
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Yeah, I just hit six months and have lost 20.5% on RUO and have not gone above 4.5mg.
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They are desperate and frustrated that their cat got out of the bag and FDA isn't bending easily to their biologic demands. Crony capitalism peaked here.
I also suspect now that they are delaying Reta submission for approval to wait out this administration and get the new pharma friendly one.
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@Newenough ROTFL yeah ask them to send vials to Jano!
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I decided to look at my trajectory vs the phase 3 trials recently because there are two of us doing this together and she is only using 2mg/ week and I'm using 8 - both with the concept of least effective dose. I'm amazed how different we are with the exact same peps, batch, reconstitution (I make the cartridges at the same time). Fascinating science fair project. We've both lost the same amount (different percentages). I'm at 16% at 13 weeks. Shows the need for personalized dosing!
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Honestly Lilly. I don’t care about percentages over time period. I want to go slow and cautiously because my $12 per month COAed glp3r is working just fine at 0.5mg every 4 days. Further, I know it can bring the heat if I need it. If it doesn’t do the trick I can throw Cagrilintide and Tesemorelin or hgh at it for another $24 a month.
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8 months. Husbands rat 3mg and 12% loss. My rat 4mg and 11%. Our goal is not to lose as much as possible as fast as possible. It’s to lose as slow as possible to sustain loss long term.
My friends rat did a fast and high titration like the trials and lost 25% in 6 months. She now does 4mg for maintenance. Anything lower and she starts to gain weight.
My theory, RUO of low and slow will be better for longer term sustained results. -
I’m down 26% since Feb…. Tesa, gym and other steps were involved but this stuff works crazy good. Almost ready to back way off to maintanence
@MacLeeezy When and how did you add in Tesa? Trying to learn about that - seeing wildly different protocols
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I mean, practically speaking if the takeaway is that RUO Reta is 82.3854% as effective as Lilly reta for 10% of the cost, most researchers would be happy taking 1.22x RUO Reta and have money to buy a car rather than spend full boat just for Reta.
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Don't forget the trials likely offer nutrition advice, accountability etc. Those alone can go along way to losing weight. I'm actually impressed RUO/stand alone efforts work 82% as well as a clinically controlled setting.
They could have picked much better examples of RUO reta "not working". Like a friend's rat. He was complaining that reta didn't work at all, blamed the drug then the vendor. Curious, I asked what dose used and how it impacted his diet/alcohol. I had to walk away when he said he hadn't taken reta in 3 weeks and only intermittently before then. Said he treated it like blood pressure meds. When he was thinking he'd be hungry he'd do a shot.
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@Newenough ROTFL yeah ask them to send vials to Jano!
@Newenough ROTFL yeah ask them to send vials to Jano!
Im actually curious if they did. A study needs to know what they are working with....
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Most of the people posting online are taking way less than the doses Lilly is giving participants in the trials. It is very common to see people posting that they are taking 0.5mg-6mg. In the trials they start at 2mg and titrate up to 12mg by the 17th week. A lot of users online seem to be people who aren't even obese as well so they have much less to lose.
@Shifted I think this is the biggest difference in such a study that doesn't compare dosing regimen of RUO vs Lilly reta.
RUO dosing isn't as "standardized" and has people starting lower (as low as 0.5mg) and not titrating as fast as Lilly. Many people don't cross 4mg.
Lilly protocol, on the other hand, starts at 2mg and essentially doubles dose every month for the next 4 months - till it hits 12mg/week. This aggressive titration leads to higher weight loss.
Interestingly, the heart rate increase was see in both RUO reta and Lilly's reta. So, that side effect is compound specific. Sema/tirz did not see any change in heart rates.
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Most of the people posting online are taking way less than the doses Lilly is giving participants in the trials. It is very common to see people posting that they are taking 0.5mg-6mg. In the trials they start at 2mg and titrate up to 12mg by the 17th week. A lot of users online seem to be people who aren't even obese as well so they have much less to lose.
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@Shifted I think this is the biggest difference in such a study that doesn't compare dosing regimen of RUO vs Lilly reta.
RUO dosing isn't as "standardized" and has people starting lower (as low as 0.5mg) and not titrating as fast as Lilly. Many people don't cross 4mg.
Lilly protocol, on the other hand, starts at 2mg and essentially doubles dose every month for the next 4 months - till it hits 12mg/week. This aggressive titration leads to higher weight loss.
Interestingly, the heart rate increase was see in both RUO reta and Lilly's reta. So, that side effect is compound specific. Sema/tirz did not see any change in heart rates.
@MickElron 100%. I have been taking Tirz for over a year now. I started with a telehealth company with standard dosing but went off the reservation after 2-1/2 months because I wasn’t eating or pooping when I went to 10mg. So I promptly started titrating down to 2.5mg, which was good to maintain, and am currently on 5-6mg as I try to lose a bit more weight while maintaining muscle.
I didn’t read the study linked above, but I’d wager a cohort of RUO patients is entirely different than a standard group.
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@MacLeeezy When and how did you add in Tesa? Trying to learn about that - seeing wildly different protocols
@SkepticJen I started Tesa and Reta around the same time so I can’t really say I noticed a difference. I started at 1mg a day 5 days on 2 days off. After doing more research I upped it to match the human trials. 2mg a day 7 days a week, but ended up taking a month off after 16 weeks, but I’ve read that you really don’t have too. I later added 400mcg of Ipamoralin because it’s said to increase the effectiveness of Tesa by 40%, but you do need to cycle that one so you don’t desensitize. I recently checked my IGF levels and I was sitting at 308.
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I can’t be the only one who has no clue what RUO means…
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