How do you calculate the overfill when adjusting your dose?
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even the compounders arent as accurate as you would like to believe.
Yes you average it for your rat. That being said eyballing 33 units vs 35 is kind of pointless. I always round to the nearest big number on syringes. I also try to keep every research protocol for the rat using the same number. so 40 units all around these days.
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I always find it amusing when these questions come up. I was there once myself. Almost everyone assumes that the compounding pharmacy is somehow precisely on the money, but then the peptide vendors aren’t. And then people talk about how tirz from one compounding pharmacy or vendor is ‘stronger’ than the same chemical from another pharmacy or vendor. There is only one scientific way I know that can make that true.
Keep in mind that the last compounding pharmacy I dealt with had me with a prescription for Clomid but wrote enclo in the comments (‘that is our system’) and I was supposed to believe they were actually sending me enclomiphene citrate no COA. There are not enough expletives for how little confidence I have in the medical industry anymore.
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There are a lot of errors and roundings in the process. You reconstitute it with a not exact amount of water, you filter it (if you do) and something is left there, you transfer it from vial to vial or to a pen, you measure it with a syringe. Do you expect it to be exact 11.85 mg divided by a dose ratio to the tens of micrograms (microliters)? Just assume the number on the label unless it's twice less than COA.
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even the compounders arent as accurate as you would like to believe.
Yes you average it for your rat. That being said eyballing 33 units vs 35 is kind of pointless. I always round to the nearest big number on syringes. I also try to keep every research protocol for the rat using the same number. so 40 units all around these days.
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@Randy thanks! Yeah I sort of figured this would be the reply..but figured it couldn't hurt to ask. You don’t know what you don't know right?
@user_6780 We all started out there. Perfectly good question. I use a spreadsheet and plug the numbers into it, including the averaging to get my dosage and units.
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For a minor overfill, I don’t even count it and dose based on the label.
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For a minor overfill, I don’t even count it and dose based on the label.
@Blueeyedme I use other peps that have overfill and I have never worried about it before; however, specifically for tirz, I am l transitioning from a compounding pharmacy, so a little different experience. I also am EXTREMELY sensitive to tirzepatide in general. I have never injected over 1mg in the last year and had to titrate up very slowly. My larger concern was more focused on an accurate dose as not to overwhelm my system with a crazy fluctuation.
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@Blueeyedme I use other peps that have overfill and I have never worried about it before; however, specifically for tirz, I am l transitioning from a compounding pharmacy, so a little different experience. I also am EXTREMELY sensitive to tirzepatide in general. I have never injected over 1mg in the last year and had to titrate up very slowly. My larger concern was more focused on an accurate dose as not to overwhelm my system with a crazy fluctuation.
@Blueeyedme I use other peps that have overfill and I have never worried about it before; however, specifically for tirz, I am l transitioning from a compounding pharmacy, so a little different experience. I also am EXTREMELY sensitive to tirzepatide in general. I have never injected over 1mg in the last year and had to titrate up very slowly. My larger concern was more focused on an accurate dose as not to overwhelm my system with a crazy fluctuation.
One thing I stand by is that for most peptides, ignoring a 20% overfill is probably fine. Doing so with GLP-1’s is a completely different thing. I would definitely go by the COA instead of the label. Your particular vial might not be spot on, but starting conservatively and titrating up based on initial findings is a good way to go.
My current tirz kit tested at 70mg for a 60mg vial, and since I typically only take 5mg, ignoring that overfill would give me a noticeable difference in suppression. The higher your dose, the less meaningful it is, but unlike other peps, dosing mistakes with GLP-1’s can punish you.
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@Blueeyedme I use other peps that have overfill and I have never worried about it before; however, specifically for tirz, I am l transitioning from a compounding pharmacy, so a little different experience. I also am EXTREMELY sensitive to tirzepatide in general. I have never injected over 1mg in the last year and had to titrate up very slowly. My larger concern was more focused on an accurate dose as not to overwhelm my system with a crazy fluctuation.
One thing I stand by is that for most peptides, ignoring a 20% overfill is probably fine. Doing so with GLP-1’s is a completely different thing. I would definitely go by the COA instead of the label. Your particular vial might not be spot on, but starting conservatively and titrating up based on initial findings is a good way to go.
My current tirz kit tested at 70mg for a 60mg vial, and since I typically only take 5mg, ignoring that overfill would give me a noticeable difference in suppression. The higher your dose, the less meaningful it is, but unlike other peps, dosing mistakes with GLP-1’s can punish you.
@ResearchCat thank you! Yes I agree!
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