CBL-514 experimental small molecule
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I purchased two vials of this and did two rounds of injections on a grid on my abdomen. The company I sourced from recommended a dose at 20% of the study max as the study was on obese subjects. I didn’t get any of the depressions from dead fat cells that were a concern but then again I didn’t see an overwhelming impact from the injections. The reconstituted solution is milky orange which was mildly concerning but I was told it was from the curcumin in the blend. End of the day I didn’t notice any magical fat loss over the past 4 weeks so guessing the dosage was too low to have any discernible impact. I may try doing a 50% dose of the study amount for one last try?
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I purchased two vials of this and did two rounds of injections on a grid on my abdomen. The company I sourced from recommended a dose at 20% of the study max as the study was on obese subjects. I didn’t get any of the depressions from dead fat cells that were a concern but then again I didn’t see an overwhelming impact from the injections. The reconstituted solution is milky orange which was mildly concerning but I was told it was from the curcumin in the blend. End of the day I didn’t notice any magical fat loss over the past 4 weeks so guessing the dosage was too low to have any discernible impact. I may try doing a 50% dose of the study amount for one last try?
Caliway owns an early patent that describes injectable micelle formulations containing resveratrol + curcuminoids for localized fat reduction. That's the predecessor chemistry to CBL-514.
Caliway describes CBL-514 as "505(b)(1) small-molecule new drug" - regulatory shorthand for a single new chemical entity.
Clinical papers for Phase 2b trial describe it the same way "a small-molecule injectable lipolysis agent that induces adipocyte apoptosis."
The recent mechanism disclosure (Wikipedia/patent-derived): a DYRK1B kinase inhibitor - again, one defined molecule.So you likely had their old version of the fat dissolver Resveratrol/Curcumin blend. This might still work to some extent.
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Lol. I just did the calculation for how much my dose would be to treat my belly. Just shy of 1500mg. The clinical trial was capped at 600mg. Would I just treat the middle of my belly and create a crater?
Doing the actual treatment doesn't sound that difficult. Get your Sharpie out and draw a grid with 1" spacing than pin 2mg at each spot. I still wonder what the end result would look like only being able to treat 10% of the surface area on somebody with my current body composition.
Oh yeah. Fun fact. At roughly $10/mg which is the lowest I see it listed for, that's $6,000 per treatment. The trial capped at 4 treatments 4 weeks apart. $24,000 to follow the dosing protocol laid out for that trial. I only see it in 20mg vials. You would need a total of 120 vials. Nuts.
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