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Tirzepatide Schedule

Scheduled Pinned Locked Moved Peptide Discussion
glp2-tdosage-discussion
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  • S Online
    S Online
    seadracos
    wrote last edited by seadracos
    #1

    Hi here, I've been using Tirz for about 3 months now and was thinking of switching from a weekly dose to a 5 day dose since the half life is 5 days.

    My hope is that this week curb some of the food noise I've started to have at the end of the week while remaining on my low dose. I'm aware that this will up the amount I take per month.

    I think I'll give it a try and if it doesn't work I'll just titrate up a bit like normal. I'm at the baby dosages still so I have room to do that.

    Had anybody else tried this or something similar?

    A newbie aficionado of magical internet powder.

    P 1 Reply Last reply
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    • S seadracos

      Hi here, I've been using Tirz for about 3 months now and was thinking of switching from a weekly dose to a 5 day dose since the half life is 5 days.

      My hope is that this week curb some of the food noise I've started to have at the end of the week while remaining on my low dose. I'm aware that this will up the amount I take per month.

      I think I'll give it a try and if it doesn't work I'll just titrate up a bit like normal. I'm at the baby dosages still so I have room to do that.

      Had anybody else tried this or something similar?

      P Offline
      P Offline
      peptidepilot
      wrote last edited by
      #2

      @seadracos said:

      Hi here, I've been using Tirz for about 3 months now and was thinking of switching from a weekly dose to a 5 day dose since the half life is 5 days.

      My hope is that this week curb some of the food noise I've started to have at the end of the week while remaining on my low dose. I'm aware that this will up the amount I take per month.

      I think I'll give it a try and if it doesn't work I'll just titrate up a bit like normal. I'm at the baby dosages still so I have room to do that.

      Had anybody else tried this or something similar?

      Hi,
      I have also been on tirzepatide since July and am currently taking a 5 mg dose (Mon–Sun). I start to get hungry on Fri–Sun as well, though I try to eat healthy.

      There are more knowledgeable people here who will share more and better opinions, and I am not too sure about the 5-day dose protocol. However, since I am in a somewhat similar situation as you, here are the options I am considering (you could try the first two and see what works best):

      Option #1: Simple and straightforward—just increase to the next dose of tirzepatide.
      Option #2: Split the dose. For example, at 5 mg, take 2.5 mg on Monday and the remaining 2.5 mg on Thursday (or 3 mg on Monday and 2 mg on Thursday).
      Option #3: I am personally debating starting 4 mg of tirzepatide and 1 mg of retatrutide starting this monday to kill the trying reta itch. 😕
      Let us know whatever works for you. Thanks

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      • ResearchCatR Offline
        ResearchCatR Offline
        ResearchCat
        wrote last edited by
        #3

        I have done 5 day dosing, but only for a couple of months near the beginning because like you, i started to get hungry after day 5. Eventually, I went back to weekly and used the last two days (Friday/Saturday) as refeed days, since I am not very hungry during the week. At this point, I am in maintenance but still barely hitting my macros.

        I don’t know much about your protocols or process, but if you are still losing weight, and the food noises is manageable, it might be fine. Otherwise, like pilot said, you could titrate up. If you are working out consistently, make sure you can hit your macros so your muscles don’t evaporate.

        I honestly don’t understand why people mix Tirz and Reta, but it’s a free country. I might switch to Reta for a couple months to see if it helps with muscle mass, but from everything I have seen, Tirz has better overall appetite suppression.

        Thus ends my rambling.

        Yeah, well, I’m just here for the research, man. - The Dude

        If I haven’t liked your post, no offense. I have exceeded my daily allowance.

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        • ResearchCatR Offline
          ResearchCatR Offline
          ResearchCat
          wrote last edited by
          #4

          I’ll add that I currently take 5-6mg/week and titrate down if I want to eat more. Weight has been pretty stable around my target for a few months. Don’t be too capricious about it, but once you are comfortable with how it works for you, making small adjustments isn’t a big deal, imo.

          Yeah, well, I’m just here for the research, man. - The Dude

          If I haven’t liked your post, no offense. I have exceeded my daily allowance.

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          • T Offline
            T Offline
            trumans-mama
            wrote last edited by
            #5

            I'm in maintenance and dose 2.5mg every 3.5 days (Friday morning/Monday evening). Nice steady state.

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            • J Online
              J Online
              jdog_rat
              wrote last edited by
              #6

              I wanted to eventually transition to reta after my telehealth prescription of tirzepatide was over (6 months), however I didn't want to start reta at the minimum after ending tirzepatide. So in month 5 I started taking reta at 1mg on day 5. I'm now at 15mg tirz and 3mg reta. It has controlled my hunger well but I am still eating enough. Once I fully go on reta I'll be at 4mg and plan to add cagrilintide

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              • S Online
                S Online
                seadracos
                wrote last edited by
                #7

                I'm still at 2.5 mg/week and will probably titrate up to 3.75 since I have a kit of 15mg/vial. I've looked at reta, but didn't really want to mess with it since I'm losing weight consistently so far may if I plateau for a month or two. I'm not really interested in loosing weight fast, plus the food noise reduction has literally been life changing for me. I'm probably going to have to always be on it.

                I've lost 80lbs before and reached my ideal weight, but I was only able to keep it off for so long before I put it on as fast as I lost it. Fortunately/Unfortunately simple calorie deficit and exercise works for me, so I don't think I'll need help from reta. Granted it's been 5 years, and I'm not going to exercise 3 hours a day again.

                A newbie aficionado of magical internet powder.

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