US production/ USA based cGMP vendors?
-
Good morning,
Admin pls forgive if I’m breaking the rules here. Not really sure where else to post this question. Loved Randy Research Rat’s vid on What’s Really in Your Peptide Vial. I was wondering if there was a way to filter vendors that have local production here in the USA with GMP facilities? So far I saw that Alpha Biomed, Paramount Pep, maybe even EZ Peptides (lyophilize) in the US. Also what do you consider US made processing, is it final synthesis or just the lyophilize part of the process? I understand that a majority of the APIs come from china or overseas and we have COAs and reviews to help create level of comfort. Thank you!
B -
Great question! IDK if there is really a way to tell given that a lot of vendors say they are made in the USA at cGMP facilities but they aren’t providing the details on that. Alpha Biomed only sells through licensed prescribers. Not sure about the others.
-
@jborja Its a bit of a mess. Rumor is that Paramount is supplied by Alpha Biomed, but Paramount effectively provides zero COAs... so you have no idea what you are getting. Rumor has it Biolongevity Labs is also supplied by Alpha Biomed, and they do provide COAs.
A big part of it is really where you choose to put your trust. Suppliers like Nexaph (which supplies EZ Peptides) provide COAs for purity and mass, and have communities that also provide additional testing for each batch from vials shipped to those customers from that batch. This still requires you to trust that (a) they are telling the truth about batches and (b) purity/mass is more or less consistent within the batch.
Paramount requires you to trust that Alpha Biomed is supplying them with stuff that is 'ok' for some unknown definition of that... I find that super wishy washy. Do I trust Chinese supplies? No. But I also don't trust US suppliers a priori either. I trust a bit more tests and incentives. That's where the Nexaph (and by extension EZ Peptides) makes me more comfortable. Because their community tests the vials they actually ship out in the batch, and Nexaph doesn't have a good way to influence that, there is a decent probability they'd be caught if they did anything shady (and they know it). Hopefully that holds and they keep being a good supplier (as has been pointed out... suppliers can go bad quickly... Paramount used to provide COAs for example).
-
Here's the best answer you're going to find: https://www.youtube.com/watch?v=p1CnfTzK5tQ
-
oh Josh…
First things first, Alpha Biomed white labels for a lot of those overpriced single-bottle brands. That’s not speculation. You can reach out to them to white label your own brand. They're too scared to sell reta to the client now...but they are happy to have you do it for them.
At the raw level, almost everything is coming out of China or India. That part is unavoidable, so yeah, the “it’s all Chinese anyway” argument isn’t wrong, but it’s also incomplete.
What actually matters is what happens after the raws show up.
Where is it being handled?
Is it being filled in a controlled cleanroom, or after hours in a facility that was running botox, lemon bottle or filler during the day?Is it a proper lab environment, or a warehouse where they’re also packing orders in open air? I’ve personally seen both ends of that spectrum.
The case for US-based operations is that they’re generally running in real cleanroom environments with tighter process control. Another big difference is raw testing. Good US labs will reject entire batches if they fail (endotoxins being the big one). That’s not something you can assume happens overseas.
So “US made” usually doesn’t mean synthesized here. It typically means processed, tested, and lyophilized here under better controls.
At the end of the day, Chinese vs US isn’t a clean win either way. Both can pass, both can fail. What you’re really evaluating is process quality and oversight, not just geography.
-
@jborja Its a bit of a mess. Rumor is that Paramount is supplied by Alpha Biomed, but Paramount effectively provides zero COAs... so you have no idea what you are getting. Rumor has it Biolongevity Labs is also supplied by Alpha Biomed, and they do provide COAs.
A big part of it is really where you choose to put your trust. Suppliers like Nexaph (which supplies EZ Peptides) provide COAs for purity and mass, and have communities that also provide additional testing for each batch from vials shipped to those customers from that batch. This still requires you to trust that (a) they are telling the truth about batches and (b) purity/mass is more or less consistent within the batch.
Paramount requires you to trust that Alpha Biomed is supplying them with stuff that is 'ok' for some unknown definition of that... I find that super wishy washy. Do I trust Chinese supplies? No. But I also don't trust US suppliers a priori either. I trust a bit more tests and incentives. That's where the Nexaph (and by extension EZ Peptides) makes me more comfortable. Because their community tests the vials they actually ship out in the batch, and Nexaph doesn't have a good way to influence that, there is a decent probability they'd be caught if they did anything shady (and they know it). Hopefully that holds and they keep being a good supplier (as has been pointed out... suppliers can go bad quickly... Paramount used to provide COAs for example).
@PeptideEd thanks for the info. How can one join the community you mentioned in reviewing more Nexaph tests?
-
oh Josh…
First things first, Alpha Biomed white labels for a lot of those overpriced single-bottle brands. That’s not speculation. You can reach out to them to white label your own brand. They're too scared to sell reta to the client now...but they are happy to have you do it for them.
At the raw level, almost everything is coming out of China or India. That part is unavoidable, so yeah, the “it’s all Chinese anyway” argument isn’t wrong, but it’s also incomplete.
What actually matters is what happens after the raws show up.
Where is it being handled?
Is it being filled in a controlled cleanroom, or after hours in a facility that was running botox, lemon bottle or filler during the day?Is it a proper lab environment, or a warehouse where they’re also packing orders in open air? I’ve personally seen both ends of that spectrum.
The case for US-based operations is that they’re generally running in real cleanroom environments with tighter process control. Another big difference is raw testing. Good US labs will reject entire batches if they fail (endotoxins being the big one). That’s not something you can assume happens overseas.
So “US made” usually doesn’t mean synthesized here. It typically means processed, tested, and lyophilized here under better controls.
At the end of the day, Chinese vs US isn’t a clean win either way. Both can pass, both can fail. What you’re really evaluating is process quality and oversight, not just geography.
