Anyone microdose it without losing weight?
I recently asked our PCP this very question (she has been recommending tirz to her patients for more than 10 years), especially for anti-inflammatory and early type 2 diabetes control purposes for a family member.
She suggested - if no weight loss is needed - starting at a very low 0.25 mg once a week to see how it behaves. People's bodies are very different one from another, and she feels flexibility is needed.
She had a patient with a weight issue and rheumatoid arthritis that eventually settled on a 2.5 mg dose once a month. That dose relieved 90% of her RA symptoms, and pulled her life out of pain territory.
I am so thankful we found a practitioner with this kind of experience with tirz.