It also changes with time, the body adapts. I only use Lilly's Zepbound tirzepatide injections. First month 2.5 mg weekly made me lose all appetite and I lost 15 pounds in 2 months. But then, I've been taking it for 6 more months increasing the dose to 9 mg (I couldn't do more b/c of the side effects), and I didn't really lose a pound consistently.