No its easy. I travel overseas frequently to Europe for business. No issues at all. You may not have a fridge, so I posted the two best choices.
This is an easy set up. https://peptidecritic.com/store/travel-freezer-pack-for-peptide-pens.
There may be no fridge available at the hotel, so you may need this from @randy video. https://www.amazon.com/dp/B0FPC2Y85Q/?coliid=I1SPTED66LIG1B&colid=2P2AONG7XZI5Q&psc=0&ref_=list_c_wl_lv_ov_lig_dp_it