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GLP's/Weight loss targeted peptides

Scheduled Pinned Locked Moved Peptide Discussion
22 Posts 6 Posters 1.8k Views 1 Watching
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  • judgetooJ Offline
    judgetooJ Offline
    judgetoo
    wrote last edited by
    #10

    Maybe these links will help you:

    https://pep-pedia.org/peptides/cagrilintide
    https://pep-pedia.org/peptides/survodutide
    https://pep-pedia.org/peptides/mazdutide

    E 1 Reply Last reply
    1
    • judgetooJ judgetoo

      Maybe these links will help you:

      https://pep-pedia.org/peptides/cagrilintide
      https://pep-pedia.org/peptides/survodutide
      https://pep-pedia.org/peptides/mazdutide

      E Offline
      E Offline
      Eleanor
      wrote last edited by Eleanor
      #11

      @judgetoo
      These are interesting. It gives the half life for Survo but can't find it for the other 2. With Survo half life of 6 days, it explains a lot. Got the notion to take Survo on Thursday and Tirz on Friday and it helps cover Survo plummet and hunger. What that actually means is I guessed right.

      Proud to be on a gubmint watch list

      1 Reply Last reply
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      • Snake PepskinS Offline
        Snake PepskinS Offline
        Snake Pepskin
        wrote last edited by Snake Pepskin
        #12

        IMG_0185.jpeg

        @beekind Cag and Eloralintide are in a different class, so I didn’t include them in the graph.
        But for contrast.

        Traditional incretins (GLP-1 and GLP-1/GIP/Glucagon agonists like Retatrutide and Survodutide) cause a transient, mild increase in resting heart rate due to autonomic stimulation.
        In contrast, both Cagrilintide and Eloralintide actually lower resting heart rate. This represents a complete divergence in how they interact with central autonomic nervous system circuits, offering a different cardiovascular footprint.

        “Knowledge is the ultimate power.
        It’s not what you know that defines you, it’s that which you share that defines you.”

        BeeKindB 1 Reply Last reply
        4
        • Snake PepskinS Offline
          Snake PepskinS Offline
          Snake Pepskin
          wrote last edited by
          #13

          97da1b05-580a-4e35-ae39-10959226c9cc-image.jpeg

          “Knowledge is the ultimate power.
          It’s not what you know that defines you, it’s that which you share that defines you.”

          E 1 Reply Last reply
          3
          • Snake PepskinS Snake Pepskin

            97da1b05-580a-4e35-ae39-10959226c9cc-image.jpeg

            E Offline
            E Offline
            Eleanor
            wrote last edited by
            #14

            @Snake-Pepskin Half lifes distinctly different that the published papers given in link above. Hmm. Thanks Snake.

            Proud to be on a gubmint watch list

            Snake PepskinS 1 Reply Last reply
            0
            • Snake PepskinS Snake Pepskin

              IMG_0185.jpeg

              @beekind Cag and Eloralintide are in a different class, so I didn’t include them in the graph.
              But for contrast.

              Traditional incretins (GLP-1 and GLP-1/GIP/Glucagon agonists like Retatrutide and Survodutide) cause a transient, mild increase in resting heart rate due to autonomic stimulation.
              In contrast, both Cagrilintide and Eloralintide actually lower resting heart rate. This represents a complete divergence in how they interact with central autonomic nervous system circuits, offering a different cardiovascular footprint.

              BeeKindB Offline
              BeeKindB Offline
              BeeKind
              wrote last edited by
              #15

              @Snake-Pepskin thank you. This is more along the lines of what I was looking for I knew someone posted a bar graph. I'm going to look more into the others. It seems there's others around the corner too that are being tested, I was reading about a bioglutide, basically reta with IGF-1.

              Just someone with a fridge full of research and a browser history that would concern my doctor.

              1 Reply Last reply
              0
              • E Eleanor

                @Snake-Pepskin Half lifes distinctly different that the published papers given in link above. Hmm. Thanks Snake.

                Snake PepskinS Offline
                Snake PepskinS Offline
                Snake Pepskin
                wrote last edited by
                #16

                @Eleanor

                Yeah, some are. My AI must be drawing from a different pond. Survo,seems a bit long, and Eloralintide. I’ll look into it.

                “Knowledge is the ultimate power.
                It’s not what you know that defines you, it’s that which you share that defines you.”

                RandyR 1 Reply Last reply
                1
                • Snake PepskinS Snake Pepskin

                  @Eleanor

                  Yeah, some are. My AI must be drawing from a different pond. Survo,seems a bit long, and Eloralintide. I’ll look into it.

                  RandyR Offline
                  RandyR Offline
                  Randy
                  wrote last edited by Randy
                  #17

                  @Snake-Pepskin or the Ai is just making things up, AI has read alot of brow science at this point. Sadly crap in crap out with Ai and when it comes to peptides on the interne there is alot of crap for it to ingest.

                  "If it doesnt come in a needle. It doesn't work"

                  Snake PepskinS 1 Reply Last reply
                  4
                  • BeeKindB Offline
                    BeeKindB Offline
                    BeeKind
                    wrote last edited by
                    #18

                    @gym.rat possibly, but I'm trying to do some research to figure out if there's a better combo for me since I'm experiencing some GI issues on Reta. Maybe it's analysis paralysis, maybe it's just me doing a different type of research, some people's minds process things differently and it's ok.

                    Just someone with a fridge full of research and a browser history that would concern my doctor.

                    1 Reply Last reply
                    0
                    • BeeKindB Offline
                      BeeKindB Offline
                      BeeKind
                      wrote last edited by
                      #19

                      @gym.rat yes, I'm currently only tolerating 1mg twice a week, anytime I try to do more in one dose I get violently sick. I've been eating better and trying to change my lifestyle while utilizing reta. I prioritize my protein. I will try the enzyme you recommended, thank you!

                      Just someone with a fridge full of research and a browser history that would concern my doctor.

                      1 Reply Last reply
                      0
                      • RandyR Randy

                        @Snake-Pepskin or the Ai is just making things up, AI has read alot of brow science at this point. Sadly crap in crap out with Ai and when it comes to peptides on the interne there is alot of crap for it to ingest.

                        Snake PepskinS Offline
                        Snake PepskinS Offline
                        Snake Pepskin
                        wrote last edited by
                        #20

                        @Randy @eleanor
                        I was too tired last night to verify.

                        After I called it out for the wrong information:

                        “You are completely right, and I appreciate the direct correction. The previous charts relied on estimated/synthetic pharmacokinetic parameters that did not align with official clinical data.
                        To correct the record, here are the verified human terminal elimination half-lives and their primary literature sources:”

                        c1cbcf3e-e5ca-4263-a693-bff0bb996d27-image.jpeg

                        “Knowledge is the ultimate power.
                        It’s not what you know that defines you, it’s that which you share that defines you.”

                        E 1 Reply Last reply
                        1
                        • Snake PepskinS Snake Pepskin

                          @Randy @eleanor
                          I was too tired last night to verify.

                          After I called it out for the wrong information:

                          “You are completely right, and I appreciate the direct correction. The previous charts relied on estimated/synthetic pharmacokinetic parameters that did not align with official clinical data.
                          To correct the record, here are the verified human terminal elimination half-lives and their primary literature sources:”

                          c1cbcf3e-e5ca-4263-a693-bff0bb996d27-image.jpeg

                          E Offline
                          E Offline
                          Eleanor
                          wrote last edited by
                          #21

                          @Snake-Pepskin I don't recall you being called out and appreciate the info. Thanks for the new chart!

                          Proud to be on a gubmint watch list

                          Snake PepskinS 1 Reply Last reply
                          0
                          • E Eleanor

                            @Snake-Pepskin I don't recall you being called out and appreciate the info. Thanks for the new chart!

                            Snake PepskinS Offline
                            Snake PepskinS Offline
                            Snake Pepskin
                            wrote last edited by
                            #22

                            @Eleanor lol, I didn't get called out. I called out my AI bot about it. And it was sorry, like my dog after she stole my sandwich.

                            “Knowledge is the ultimate power.
                            It’s not what you know that defines you, it’s that which you share that defines you.”

                            1 Reply Last reply
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