Tesamorelin alone or Tesa/Ipa blend
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So is the combination best or having them separate?
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Use them in combination but pin them separately so you can manage the quantity of each. I actually use the 10/3 blend but I'm good with 1mg/300mcg nightly. Others prefer a different dose of each.
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Tesamorelin can be run continuously for up to 52 weeks in studies without losing the efficacy, but Ipamorelin needs a break after 12 weeks to restore receptors sensitivity.
@vpeptides FYI - I thought the same for Ipamorellin, but after watching the Alex Kikel GH peptide seminar, that led me to try and to find research on Ipamorellin casuing receptor fatigue, there is no eveidence I can find that Ipamorellin causes receptor desensitization. In fact it was the opposite and my mind was blown becasue I always thought this needed a cycle. I could only find a study showing NO receptor desensitization. Alex claims only Hexarellin casues desesitization and its rapid. Check it out and let me know if you have any other sources showing it does cause receptor fatigue becasyue I can't find it but I've heard many Gurus make the claim so I went with it until I watched the seminar and looked for reearch on it.
Let me know if you can find anything on it though I'm interested in this becasue I love IPA the podcast is bellow
The Prep Coach - GROWTH HORMONE PEPTIDES (SEMINAR & PROTOCOLS) -
Looking to start a cycle of either Tesamorelin by itself or the Tesamorelin/ipamorelin 10/3mg blend. Is the blend that much more advantageous over tesamorelin alone? I was thinking of doing 1mg tesa and 300mcg ipamorelin Monday-Friday to start. I did read that ipamorelin makes more sense to do in the morning while tesa better at night so would it not really make sense to get the blend then?
@e_kantor2 .... I've run both and I prefer the Tesa/IPA at night before bed 3 hours fasted. but either way you can try Tesa solo for a few months then add the IPA and figure out what you prefer becasue everyone is different.
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@vpeptides FYI - I thought the same for Ipamorellin, but after watching the Alex Kikel GH peptide seminar, that led me to try and to find research on Ipamorellin casuing receptor fatigue, there is no eveidence I can find that Ipamorellin causes receptor desensitization. In fact it was the opposite and my mind was blown becasue I always thought this needed a cycle. I could only find a study showing NO receptor desensitization. Alex claims only Hexarellin casues desesitization and its rapid. Check it out and let me know if you have any other sources showing it does cause receptor fatigue becasyue I can't find it but I've heard many Gurus make the claim so I went with it until I watched the seminar and looked for reearch on it.
Let me know if you can find anything on it though I'm interested in this becasue I love IPA the podcast is bellow
The Prep Coach - GROWTH HORMONE PEPTIDES (SEMINAR & PROTOCOLS)@bfuller You are right. I only referred to the narrative from all the leading influencers in this matter. "12-week timeline" for Ipamorelin desensitization is primarily an anecdote and clinical convention.
One one hand, the target of Ipamorelin, GHS-R1a (ghrelin) receptor undergoes rapid desensitization when exposed to continuous stimulation, is proven science, in general.
But there are no trials for Ipamorelin, specifically. Only a note by Novo Nordisk that Ipamorelin was remarkably unique because it resisted the acute, rapid desensitization seen in Hexarelin.
I would speculate it does desensitize the receptor eventually, but perhaps significantly slower than in 12 weeks, after looking at the evidence (or the absense of it). Thank you!attentiion is all you need
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@bfuller You are right. I only referred to the narrative from all the leading influencers in this matter. "12-week timeline" for Ipamorelin desensitization is primarily an anecdote and clinical convention.
One one hand, the target of Ipamorelin, GHS-R1a (ghrelin) receptor undergoes rapid desensitization when exposed to continuous stimulation, is proven science, in general.
But there are no trials for Ipamorelin, specifically. Only a note by Novo Nordisk that Ipamorelin was remarkably unique because it resisted the acute, rapid desensitization seen in Hexarelin.
I would speculate it does desensitize the receptor eventually, but perhaps significantly slower than in 12 weeks, after looking at the evidence (or the absense of it). Thank you!@vpeptides, I read a mouse study where acute doses were given for 21 days and no measurable receptor desensitization was measured like was recorded with different analogs acutely dosed over the same time frame. But then again mice and short timeline but even so these were acute doses so you would imagine if there was something there it would be measurable. Oh well over the last 10 years I thought all GHRP's caused receptor desensitization, but now I'm learning maybe not?
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My raccoon underwent quite a weight loss journey starting in January and by far the most intense period of it was when I introduced tesa/ipa. Its never gone over 1.5 tesa .3 ipa and it absolutely nuked its midsection fat. It started in size 38 jeans and is now in 30's
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My raccoon underwent quite a weight loss journey starting in January and by far the most intense period of it was when I introduced tesa/ipa. Its never gone over 1.5 tesa .3 ipa and it absolutely nuked its midsection fat. It started in size 38 jeans and is now in 30's
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@Mr-Smurf Did that transition in your raccoon cause any loose skin in the process?
@Reactive3078 yes a little bit. Actively fighting it with extra core exercises to build its muscle outwards, microneedling, ghk serum, ghk/kpv injections, extra aggressive on the ghk (5mg), collagen/glycine supplementing, tretinoin cream, and higher tesa/ipa dose to induce more igf1 locally. It turned out to be a much higher responder than initially planned for and things got out of hand fast, luckily no folding, just some laxity
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@randy should have an AI summary box on this forum. I'm missing out on long discussions if I don't come online for a day or even a few hours.
@pep_researcher if you have AI you can ask it to read the forum and tell you which threads and updates are of interest to you. Over time, it will become alarmingly well tuned to your preferences.
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@Reactive3078 yes a little bit. Actively fighting it with extra core exercises to build its muscle outwards, microneedling, ghk serum, ghk/kpv injections, extra aggressive on the ghk (5mg), collagen/glycine supplementing, tretinoin cream, and higher tesa/ipa dose to induce more igf1 locally. It turned out to be a much higher responder than initially planned for and things got out of hand fast, luckily no folding, just some laxity
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@Mr-Smurf This is exciting to me. My research is having a hard time losing mid-section fat. I'll have to try Tesa. With the Ghkcu you said you have 5mg. Mine is 2.5mg. Is it safe to go up to 5mg?
@tmdeck9904 Start low and go from there. My body seems to take ghk quite well no stinging no drama but it isnt the case for everyone.
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Thank you
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