Nasal Spray Vendors & Questions
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I honestly want to find out how they do those room temp preservatives to see if I can just make my own. And if the preservatives affect potency compared to bac/saline combos for things like adamax and na-selank.
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Ill take a shot at this using Nasonex as an example. I use to get seasonal allergy attacks and was stocked against it for the season. I had bottles of Nasonex at my desk, vehicle and backpacks. Some of these bottle are a year old and still worked. So let's dive in on what they did to keep it stable.
Nasonex can stay effective at normal room temperature because Its active ingredient, mometasone furoate monohydrate (the engineered steroid).
The medicine is made is chemically stable and doesn’t break down easily. The medicine is made as a carefully designed water-based mixture that keeps the ingredient evenly distributed and protected.Nasonex can stay effective at normal room temperature because:
Its active ingredient, mometasone furoate monohydrate, is chemically stable and doesn’t break down easily.
The medicine is made as a carefully designed water-based mixture that keeps the ingredient evenly distributed and protected.
In simple terms, Nasonex is specially made so that ordinary indoor temperatures usually don’t damage it or make it stop working."What is in the nasanex water-based mixture that keeps the ingredient evenly distributed and protected
Nasonex is not simply a solution—the medicine is a suspension, meaning tiny particles of mometasone are mixed throughout water rather than dissolved in it.
The water-based mixture generally contains:
Purified water — the liquid base
Microcrystalline cellulose and carboxymethylcellulose sodium — thickening and suspending agents that help keep the medicine particles from quickly settling; this is why you shake the bottle
Glycerin — helps control moisture and the feel of the spray
Polysorbate 80 — helps the ingredients mix evenly
Sodium citrate and citric acid — help maintain the proper acidity, or pH
Benzalkonium chloride — a preservative that helps prevent microbial growthIn plain language: some ingredients make the liquid thick enough to keep the drug floating, some help everything mix together, some keep the acidity stable, and the preservative helps keep the spray from becoming contaminated. The exact ingredients can vary by product or market, so check your bottle’s package insert. The U.S. Nasonex 24HR Allergy label lists these inactive ingredients."
So yes you can add more stability by adding the above for example. Maybe a little more Benzyl alcohol. If instead of just saline, use only BAC. I DIY all my sprayers with reconstituded BAC and the rest I further dilute with Saline, and keep them in the refrigerator.
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@nobleone Did you reach out to the companies and ask?
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@nobleone Did you reach out to the companies and ask?
@Mydogdaryl423 Lots of googling and AI. I looked over the actual insert and I glazed over it.
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Lots of googling and AI. I looked over the actual insert and I glazed over it. When you read a quote unquote, it is a cut and paste. But it does make sense if you dig deeper. I am sure vendors here are taking good notes. Please correct me if I'm wrong. Its part of "researching". Stupid is the stupid not willing to ask stupid questions. How else will they learn? -
@nobleone Did you reach out to the companies and ask?
@Mydogdaryl423 Forgot to add that to the original post. When I reached out to Crush, I specifically asked for an official formulation and shelf life, which is why I know about the supposed 6 month shelf life.
As for the formulation, the rep said they would talk to the owners to see if they could have the formulation posted on the website itself. I'm not really hopeful on that part though tbh, especially if it's some proprietary formulation.
I'll reach out to Mile High just for info, but their pricing makes it a no go for me regardless.
I only use 3-4 vendors and most of them don't have sprays, which was a big reason for this post, hoping others have vetted vendors that have listed formulations.
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Ill take a shot at this using Nasonex as an example. I use to get seasonal allergy attacks and was stocked against it for the season. I had bottles of Nasonex at my desk, vehicle and backpacks. Some of these bottle are a year old and still worked. So let's dive in on what they did to keep it stable.
Nasonex can stay effective at normal room temperature because Its active ingredient, mometasone furoate monohydrate (the engineered steroid).
The medicine is made is chemically stable and doesn’t break down easily. The medicine is made as a carefully designed water-based mixture that keeps the ingredient evenly distributed and protected.Nasonex can stay effective at normal room temperature because:
Its active ingredient, mometasone furoate monohydrate, is chemically stable and doesn’t break down easily.
The medicine is made as a carefully designed water-based mixture that keeps the ingredient evenly distributed and protected.
In simple terms, Nasonex is specially made so that ordinary indoor temperatures usually don’t damage it or make it stop working."What is in the nasanex water-based mixture that keeps the ingredient evenly distributed and protected
Nasonex is not simply a solution—the medicine is a suspension, meaning tiny particles of mometasone are mixed throughout water rather than dissolved in it.
The water-based mixture generally contains:
Purified water — the liquid base
Microcrystalline cellulose and carboxymethylcellulose sodium — thickening and suspending agents that help keep the medicine particles from quickly settling; this is why you shake the bottle
Glycerin — helps control moisture and the feel of the spray
Polysorbate 80 — helps the ingredients mix evenly
Sodium citrate and citric acid — help maintain the proper acidity, or pH
Benzalkonium chloride — a preservative that helps prevent microbial growthIn plain language: some ingredients make the liquid thick enough to keep the drug floating, some help everything mix together, some keep the acidity stable, and the preservative helps keep the spray from becoming contaminated. The exact ingredients can vary by product or market, so check your bottle’s package insert. The U.S. Nasonex 24HR Allergy label lists these inactive ingredients."
So yes you can add more stability by adding the above for example. Maybe a little more Benzyl alcohol. If instead of just saline, use only BAC. I DIY all my sprayers with reconstituded BAC and the rest I further dilute with Saline, and keep them in the refrigerator.
@EXTROPIAN This is awesome! I definitely thought about doing a pure bac spray, but the hippie in me is admittedly a little concerned a pure bac spray could mess up my nasal microbiome...lol
Haven't actually seen anything on this, it just makes logical sense to me personally.
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For what it’s worth, I’m currently using NAD+ Nasal, no discomfort whatsoever. Most people that inject it complain about ISRs. I haven’t injected it before so I don’t have a reference on that. I AM curious about GHK-Cu nasal though.
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@EXTROPIAN This is awesome! I definitely thought about doing a pure bac spray, but the hippie in me is admittedly a little concerned a pure bac spray could mess up my nasal microbiome...lol
Haven't actually seen anything on this, it just makes logical sense to me personally.
@NobleONe
The only thing I’ve heard about BAC nasally is that it can dry your sinus membranes, but it not concentrated enough to be antiseptic. I still use sterile saline, and never had an issue with anything for as long as 60-90 days refrigerated. Although having it not need refrigeration would be sweet.“Knowledge is the ultimate power.
It’s not what you know that defines you, it’s that which you share that defines you.” -
@NobleONe
The only thing I’ve heard about BAC nasally is that it can dry your sinus membranes, but it not concentrated enough to be antiseptic. I still use sterile saline, and never had an issue with anything for as long as 60-90 days refrigerated. Although having it not need refrigeration would be sweet.@Snake-Pepskin Will they share their secret sauce?
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I’m sure it something easy enough to get, I just haven’t looked into it for nasal compounds. If smell a rabbit hole ahead.
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@EXTROPIAN This is awesome! I definitely thought about doing a pure bac spray, but the hippie in me is admittedly a little concerned a pure bac spray could mess up my nasal microbiome...lol
Haven't actually seen anything on this, it just makes logical sense to me personally.
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For what it’s worth, I’m currently using NAD+ Nasal, no discomfort whatsoever. Most people that inject it complain about ISRs. I haven’t injected it before so I don’t have a reference on that. I AM curious about GHK-Cu nasal though.
@Snake-Pepskin Only one way to find out.
Personally I would keep metabolic, repair, michondria... Anything to do with the body subq. Anything ralated the brain nasal. I believe is a target delivery. Ghkcu nasal might be a good delivery if you want to target facial. But what are the neurological implications? I do get a light face flush with nasal reta. If ghkcu does the same. Hmmm -
@Snake-Pepskin Only one way to find out.
Personally I would keep metabolic, repair, michondria... Anything to do with the body subq. Anything ralated the brain nasal. I believe is a target delivery. Ghkcu nasal might be a good delivery if you want to target facial. But what are the neurological implications? I do get a light face flush with nasal reta. If ghkcu does the same. Hmmm -
@EXTROPIAN Nasal reta is interesting...what made you want to try that out? lol
@NobleONe I been meaning to do a Retanasal for quite sometime. I am going to finish my 5mg nasal sprayer. I am updating my personal experience in my post under "Retatrutide The Mount Nose More Battle (Intranasal Reta)". Definantely has application.
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Here's what Mile High said to me after I asked them about their formulation:
"Our sprays are formulated with the compound and a 0.9% benzyl alcohol preservative blend specifically to support stability in solution. They are designed and tested to remain stable without refrigeration under normal shipping and storage conditions and do not require refrigeration once received.
We have third-party testing through Vanguard supporting the stability of these products as shipped. If you’d like to verify directly, you’re welcome to contact Vanguard Scientific regarding the testing performed on our spray formulations. We’re happy to provide any batch or product details needed to facilitate that."
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I followed up with Mile High and asked them to break down the specific preservative blend and received this response:
"The preservative is 0.9% benzyl alcohol and it does not need to be refrigerated."I may be over thinking all of this, but figured I would share the info. I've received.
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I followed up with Mile High and asked them to break down the specific preservative blend and received this response:
"The preservative is 0.9% benzyl alcohol and it does not need to be refrigerated."I may be over thinking all of this, but figured I would share the info. I've received.
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