SS-31 (Elamipretide) — Research Dosing Protocol
-
@PeptidePete let us know how it goes. I just finished it a few days ago. My only real complaint is the itchy ISR i got as the dose went up.
@Randy said in SS-31 (Elamipretide) — Research Dosing Protocol:
@PeptidePete let us know how it goes. I just finished it a few days ago. My only real complaint is the itchy ISR i got as the dose went up.
Will do
Yes, it is a bit itchy for me as well, but no big deal.
I thank you again for sharing this protocol! Not for the faint of heart or wallet but what's the value of having rejuvenated and repaired mitochondria? Priceless in my world.
-
It’s funny, this research world. I was talking to a friend about my upcoming SS-31 research protocol and he thought I was loopy telling him about the one above that I am planning to replicate as best I can up to the pulse phase and see from there.
I guess he is currently running the popular SS-31/MOTS-C one which has you running it if not forever, then quite frequently.
But he is telling me that after 2 weeks at 2mg/day, he is seething with energy. I am mostly looking for the metabolic repair and reset so will run this course after finishing epitalon, then do a MOTS-C cycle, and look into NAD+ down the road.
Funny story; my whole journey into this stuff started last year when I was researching longevity and started taking NAD, NMN, and a few other supplements that turn out to have terrible oral availability. And down the rabbit hole I went. I still take pterostilbene because in theory anyway, this comes from blueberries and has decent bioavailability when taken orally.
-
@PeptidePete let us know how it goes. I just finished it a few days ago. My only real complaint is the itchy ISR i got as the dose went up.
@Randy said in SS-31 (Elamipretide) — Research Dosing Protocol:
@PeptidePete let us know how it goes. I just finished it a few days ago. My only real complaint is the itchy ISR i got as the dose went up.
Currently finishing up some 40mg vials which I was reconstituting with <1ml and it was too uncomfortable at that concentration in one pin in one spot. Switched to doubling the dilution, two 1ml pins in adjacent sites. Everything hunky-dory now.
Also was pinning in the AM, now switched to PM as my pin load is less at night. Less chance of cross-talk issues, and perhaps its magic works better while the body is doing other clean up. Who knows.
-
That is really timely. I was just starting to look at FOX-04 DRI, and just saw a new video on it. It seems like with all the attention SS-31/MOTS-C/NAD+ are getting that FOX is as well. Clearing out senescent cells sounds like a great idea, but I’d be a bit concerned with killing off 10%(one number I saw) of my cells without better understanding of what they get replaced with.
Definitely requires a bit more research on my part. Thank goodness it’s expensive.
@ResearchCat Im a bit conservative about jumping in to that Fox clean out…Doing a 7 day fast should do the clearing out of damaged cells naturally. I started with MotsC now going to run Just SS 31 with 5 amino 1Q for a month. I had been exposed to mold at times and leaning more on healing and recovery before anything too aggressive. Diego has some knowledge but is aggressive. Im 62 and still working hard so I will try this for restoration. I did love the MotC for the week but felt it was needing more each day so fixing the leaking mitochondria seems to be my plan.
-
I just started the SS-31 protocol Randy shared above. Question for the community....what is a good follow up protocol moving onto MOT-C when I finish the SS-31 protocol? When I repair the good remaining cells, what's a good cycle for fueling them? Thank you for your input!
-
I just started the SS-31 protocol Randy shared above. Question for the community....what is a good follow up protocol moving onto MOT-C when I finish the SS-31 protocol? When I repair the good remaining cells, what's a good cycle for fueling them? Thank you for your input!
-
Hey good Afternoon. I have a 10pack of 50mg SS31 on the way to research with. This is about 14 vials short of being able to complete this protocol.
I am looking to do a miniature version of this and would appreciate any feedback from the community on if you think this will work well given my limited supplies or if I’m titrating up too quickly:
Weeks 1-3: 4mg Daily
Weeks 4-6: 8mg Daily
Weeks 7-9: 25mg 3 times per weekThanks!
-
Hey good Afternoon. I have a 10pack of 50mg SS31 on the way to research with. This is about 14 vials short of being able to complete this protocol.
I am looking to do a miniature version of this and would appreciate any feedback from the community on if you think this will work well given my limited supplies or if I’m titrating up too quickly:
Weeks 1-3: 4mg Daily
Weeks 4-6: 8mg Daily
Weeks 7-9: 25mg 3 times per weekThanks!
@MacLeeezy im doing this protocol and i bought the 1gr required.
If you dont have enough probably cut on the 25mg and lower that dosez
-
My rat just got ss-31 in today and after reading this, I think
Weeks 1-3: 4mg Daily
Weeks 4-6: 8mg Dailyshould work yes?
@macleeezy @diegoc since you guys are both using this for your rats also, did you guys notice anything when doign 4mg right off the bat?
just to confirm:
Using the peptide calculator,
Desired dose is 4MG,
Vial size is 10MG
2ML bac waterI would need to give my Rat 80 units daily?
-
@imemphis I've done 4mg (just finished that part and moved to 10mg in the last few days) - was a pretty easy adjustment. That said, and with the caveat that the following comment is a matter of taste, I'd go with 1 mL to a 10mg vial and do 40 units. From where I sit, for me, 80 units is a lot in an injection. When I did 4mg I did specifically 10mg/mL concentration and thus 40 units for 4mg. To be clear, its a matter of taste, there's nothing wrong with your plan if 80 unit shots are comfortable for you
-
Thanks for the heads up @peptideed !
-
My rat just got ss-31 in today and after reading this, I think
Weeks 1-3: 4mg Daily
Weeks 4-6: 8mg Dailyshould work yes?
@macleeezy @diegoc since you guys are both using this for your rats also, did you guys notice anything when doign 4mg right off the bat?
just to confirm:
Using the peptide calculator,
Desired dose is 4MG,
Vial size is 10MG
2ML bac waterI would need to give my Rat 80 units daily?
-
I just finished my SS-31 run. I decided to do phases 1-2 and skip the burst phase mainly due to costs. I did a concentration of 10mg in 40 units (~24mg/ml). I occasional mild ISR but no worse than from 12 units of glow. I found using the gansulin pen made it a breeze.
Now running MOTS-C and planning to add NAD+.
-
@researchcat Dr Sawicki dropped a short on YouTube about how antioxidants block Mot-C from entering the cell. So you’ll probably want to research Mot and NAD on different runs.
https://youtube.com/shorts/W2a9qZ7vP1k?si=3-iRJFN2so7hVyLx -
@researchcat Dr Sawicki dropped a short on YouTube about how antioxidants block Mot-C from entering the cell. So you’ll probably want to research Mot and NAD on different runs.
https://youtube.com/shorts/W2a9qZ7vP1k?si=3-iRJFN2so7hVyLx@MyB that’s interesting. My inclination was to do them all separately, but it seems a lot of people (YouTubers) are suggesting you blast everything all together. Appreciate the tip.
Edit: Oh, I see, so not saying you can’t research them together, but that you shouldn’t research them at the same time of day.
-
@researchcat i made a post under the mot-c dosing topic. https://community.peptidecritic.com/post/2819
Based on half life’s, dosing Mot-C then dose NAD+ 8 hrs later would get full benefits of both without overlap. -
@researchcat Dr Sawicki dropped a short on YouTube about how antioxidants block Mot-C from entering the cell. So you’ll probably want to research Mot and NAD on different runs.
https://youtube.com/shorts/W2a9qZ7vP1k?si=3-iRJFN2so7hVyLx
