Efficacy of nasal vs. subQ for neuro peptides
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I recently did a trial of subQ PE-22-28 to evaluate mood enhancement and increased memory and learning with my post-stroke research guinea pig.
While there was some improvement it was slight so I decided to run a trial with nasal administration. The difference is very noticeable! Onset is much quicker and benefits are much more obvious.
I'm looking into possibly trialing DSIP & pinealon. Curious if anyone has researched others on subQ vs nasal that were revealed to have better efficacy with nasal route?
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I do glutathione as a nasal spray because it crosses the blood brain barrier easier. It also increases glutathione in the brain significantly over subq or iv. As long as your peptide has a molecule weight under 500 daltons it is a candidate for nasal administration. If it is a peptide that crosses the BBB you will get better concentrations in the brain and nervous system via nasal administration.
You can test using a nasal dart. It is an atomizer with luer lock end. It can be reused as long as it is only reused on the same research subject. You will also want to dilute with saline because bac water alone stings something terrible.
