Tesamorelin Research Dosing Protocol

[Randy]

For research use only. Not medical advice.

Overview

Tesamorelin is a synthetic 44–amino acid GHRH analog that stimulates endogenous GH release and raises IGF-1 levels.
It is FDA-approved for reducing visceral fat and is widely researched for body composition, metabolic enhancement, and aging-related applications.
Most research follows the standard 2 mg once-daily subcutaneous protocol.

Daily Dosing Protocol (Subcutaneous)

Standard Daily Dose

2 mg once daily

Administered consistently at the same time each day (often in the evening to align with nocturnal GH rhythms).

Optional Titration Schedule

Some researchers prefer to begin with a short ramp to improve tolerability.

Week 1

1 mg daily

Weeks 2–12+

2 mg daily

This is the typical working and maintenance dose used in clinical and research settings.

Cycle Length

While Tesamorelin can be used continuously, the most common research patterns are:

8–12 weeks on protocol, followed by

2–4 weeks off, then repeat as needed.

Longer continuous use (12–24+ weeks) is also documented in research settings.

Alternate Timing Strategies

Although daily evening administration is the classic model, researchers may use morning Dosing

Chosen when subjects report improved energy or reduced nighttime hunger signals.

Split Dosing

1 mg twice daily

Used occasionally to blunt injection-site reactions or flatten GH spikes.

[lancerlot23]

I’ve been taking Tesamorelin for 2 weeks—1 mg during the first week and 2 mg at night during the second week. I inject it about 30 minutes before bed, with no food for at least 3 hours beforehand.
Since starting it, my nighttime heart rate has increased. My average resting heart rate used to be around 60, but recently it’s been 86, 70, and 69. My stress levels have been very high, I’m not getting any REM sleep, and I’m having trouble sleeping overall.
I know that this is an evening Peptide, but would AM hour work better maybe? I could pause for a couple of days and see if my heart rate and sleep normalize also.

[Randy]

I do it in the morning fasted with my AOD and just don't touch food for 3-4 hours. It makes it easier on GLP as well where digestion is slow and you need to wait longer.

Sleep disturbances are a common occurrence with tesa on lab rats.

[lancerlot23]

Thank you sir....

[Randy]

I should also note weve seen researchers say an hour is all you need after but randy hates breakfast and only gets lunch if he sits still when we record videos.

[ResearchCat]

Thoughts on doing a Tesa/Ipa protocol? I was watching a video yesterday talking about doing that with a morning injection schedule to take advantage of overnight fasting and then not eating for a few hours. This would work well for intermittent fasting regimens, might help with sleep, and is supposed to be better for shredding.

I just finished a CJC/IPA cycle and between the challenge of fasting (I don’t get home til after 9 a lot) and not sleeping great on it, I’m thinking about alternatives down the road. CJC/IPA definitely works for me but might not be ideal, and sermorelin is quite subtle.

[TShivers]

@ResearchCat.... I've been on the Tesamorelin and Ipamorelin injections for several wks now so far with EXCELLENT results.... I do (2) injections daily of Ipamorelin....0.25mg of Ipamorelin dose in the mornings (fasted before breakfast) and another 0.25mg dose of Ipamorelin at night before bed for 5 days a wk.
The Tesamorelin I take just once nightly at a 2mg dose before bed for 5 days a week.
Saturday and Sundays are my days off
Hope this helps answer your question.

[justalittleprick]

@TShivers said in Tesamorelin Research Dosing Protocol:

@ResearchCat.... I've been on the Tesamorelin and Ipamorelin injections for several wks now so far with EXCELLENT results.... I do (2) injections daily of Ipamorelin....0.25mg of Ipamorelin dose in the mornings (fasted before breakfast) and another 0.25mg dose of Ipamorelin at night before bed for 5 days a wk.
The Tesamorelin I take just once nightly at a 2mg dose before bed for 5 days a week.
Saturday and Sundays are my days off
Hope this helps answer your question.

Did you start at 2mg and .5mg or did you titrate up to that level?