Tesamorelin Research Dosing Protocol
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Hey friends, @randy might have opined on this also, but curious to hear what others think. I saw another video that nightly tesamorelin might be impacted for those taking Tirz or Reta due to slowed gastric emptying, meaning that folks are not as truly fasted and still carrying heavier insulin when they poke before bed.
I like Tesamorelin/ipa at nights due to restful and deeper sleep (even with toddlers), but I am on tirz and try to have my last bite 3 hours before bed. Not sure if eating dinner 4 hrs before is doable..
Curious to hear your thoughts about a morning routine instead? For you morning folks, do you just wait at least 30 mins before a pre workout? I was gonna try Tesa at night and Cjc in the morning but might be reconsidering this to not have duplicative secretagogues at the same time. Ty! -
I am researching Tirz and have cycled sermorelin and CJC/Ipa, fasting 2 hours before, and it works. Don’t let the perfect be the enemy of the good.
Currently pinning tesa right when I get up and trying to fast for 2 hours after because I get home late and fasting 2-3 hours before bed makes it hard to hit my macros. Will let you know in a few weeks how it’s working.
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Hey friends, @randy might have opined on this also, but curious to hear what others think. I saw another video that nightly tesamorelin might be impacted for those taking Tirz or Reta due to slowed gastric emptying, meaning that folks are not as truly fasted and still carrying heavier insulin when they poke before bed.
I like Tesamorelin/ipa at nights due to restful and deeper sleep (even with toddlers), but I am on tirz and try to have my last bite 3 hours before bed. Not sure if eating dinner 4 hrs before is doable..
Curious to hear your thoughts about a morning routine instead? For you morning folks, do you just wait at least 30 mins before a pre workout? I was gonna try Tesa at night and Cjc in the morning but might be reconsidering this to not have duplicative secretagogues at the same time. Ty!@jborja said in Tesamorelin Research Dosing Protocol:
Hey friends, @randy might have opined on this also, but curious to hear what others think. I saw another video that nightly tesamorelin might be impacted for those taking Tirz or Reta due to slowed gastric emptying, meaning that folks are not as truly fasted and still carrying heavier insulin when they poke before bed.
I like Tesamorelin/ipa at nights due to restful and deeper sleep (even with toddlers), but I am on tirz and try to have my last bite 3 hours before bed. Not sure if eating dinner 4 hrs before is doable..
Curious to hear your thoughts about a morning routine instead? For you morning folks, do you just wait at least 30 mins before a pre workout? I was gonna try Tesa at night and Cjc in the morning but might be reconsidering this to not have duplicative secretagogues at the same time. Ty!I only research my GHRH/GHRP peptides in the a.m., first thing fasted now, for a whole bunch of reasons. It's just easier and more convenient for me, I know I'm totally fasted with insulin at its lowest point (and therefore getting the strongest amount of receptor saturation as possible).
Plus I'm just more awake/alert in the a.m., easier to pin and reconstitute if need be. I spent many late nights in years past pinning/researching before bed after a long day and when tired, it's just difficult.
I wait 2 hours before eating anything. I drink black coffee right away in the morning after pinning and the combo of peptides, coffee and being fasted in the a.m. is a superpower for getting stuff done. Plus I find GH peptides stimulating in a way in the morning.
I like the idea of going natural at night (no GH peps) and really letting my natural production do its thing. I have found that there must be some carry over anyways, because on cycle my rat sleeps better even though he pins in the a.m only.
Rather than trying to find a way to squeeze in Tesa/CJC in the same day, I'd recommend you use one or the other during your cycle. You can flip flop them as well, going back and forth when one vial runs out.
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Want to give a shoutout to Tesa from a 60-year-old male. I have been injecting 1mg Sun-Thurs for 12 weeks (among other things including Testosterone, Reta, GHK-Cu and Semax/Selank). Scan from yesterday showed a drop in visceral fat from 112 cm² to 70.3 cm² (37% reduction). Obviously, the Testosterone and Reta played a part, but I can definitively say it helped me. I'm a big fan. I'm taking a 2-week break and will start another cycle again. Can't say enough good things.
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I left a review for crush when they weren’t listed because I understood it to be open. Think they get added based on reviews?
@WisGal64 oh really? I deleted my post because it didn’t have a tag for the vendor. But I’ll re-upload it
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Thoughts on doing a Tesa/Ipa protocol? I was watching a video yesterday talking about doing that with a morning injection schedule to take advantage of overnight fasting and then not eating for a few hours. This would work well for intermittent fasting regimens, might help with sleep, and is supposed to be better for shredding.
I just finished a CJC/IPA cycle and between the challenge of fasting (I don’t get home til after 9 a lot) and not sleeping great on it, I’m thinking about alternatives down the road. CJC/IPA definitely works for me but might not be ideal, and sermorelin is quite subtle.
@ResearchCat I was doing my second vial of chc/ipa and was really loving the sleep and recovery. I heard a video of adding tesamoreline so added .5 mg then stopped the cjc and was doing 1 mg of Tesa at night for a week. I had one more dose left but I tossed it.
My back got sore, my joints were stiff and it felt like tesa was working completely against my recovery stack.
Last night, my sleep wasn’t as good and needed to take a KPV to help with all that inflammation. I also ate some yogurt which hunger seems to be working against the body composition goals. Im going to the hotsprings, taking the weekend off and may restart my cjc/ipa Monday night. I also did a BPC 157 this morning with another KPV, which is helping. Tesa is NOT for me… -
Well, all this just kinda blows me out of the water. I need to get rid of a lot of visceral fat; I mean A LOT. The DEXA was horrible! I'm not that overweight, but the Dr. said, and I concur, it's been there a long time and I was raised on a Southern diet. I'm currently taking Tirzep once/wk on Friday night; nothing to eat since lunch, except very light snack later so stomach's not growling. NAD+ M,W & Sat, mornings upon waking, approx 10 hour fast. I have trouble sleeping and get up at 4:30, so not sure where to fit in Tesa. Question for all, but esp. for @randy Do Tesa and NAD+ work well together? I can cut back on the NAD, but not the Tirzep. I could also stay on lower does of Tesa for longer. What do y'all think?
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M.D.? Someone mentioned somewhere on this blog that all the influencers out there are DC's or anything other than MD's. Maybe this one is MD? Got to go to work right now but will look up licensing this weekend.
https://youtu.be/Ky5Hodz3-9A?si=P0iLJhekK0GujTSo -
What is the NAD+ for? I don’t know your history or goals, but almost think that MOTS-C might be more effective if you are trying to burn fat, especially if you are exercising.
I see no issues researching NAD+/MOTS-C with a GHRH. You can research Tesa/Ipa/CJC first thing in the morning fasted or an hour before bed after fasting 2-3 hours.
I am not a doctor, or your doctor, but I like to have a specific goal and purpose for whatever peptides I am researching, even if I am researching several at the same time. ;). At the moment, I am much more bullish on MOTS-C than on NAD+ as part of an ongoing maintenance stack.
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What is the NAD+ for? I don’t know your history or goals, but almost think that MOTS-C might be more effective if you are trying to burn fat, especially if you are exercising.
I see no issues researching NAD+/MOTS-C with a GHRH. You can research Tesa/Ipa/CJC first thing in the morning fasted or an hour before bed after fasting 2-3 hours.
I am not a doctor, or your doctor, but I like to have a specific goal and purpose for whatever peptides I am researching, even if I am researching several at the same time. ;). At the moment, I am much more bullish on MOTS-C than on NAD+ as part of an ongoing maintenance stack.
@ResearchCat NAD+ really kept me on my feet when I first started Tirzep; I still have 4 vials of it and am going to use it. Depending on how I'm feeling when I've used it up will determine if I buy more. When something works, I try not to change it. Problem is that I get relatively wired on it; I have a high stress job, and have trouble sleeping. I've recently reduced the dose, so will see if I can find a sweet spot. Thanks for the ideas! I imagine I will try a number of them before all's said and done.
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If you are suffering a loss of energy while on Tirz, it may be because you aren’t eating enough. I know it is hard to do, but when I was above 7.5 mg tirz, I had to force myself to eat in order to hit my macros. At 10mg, I had no desire to eat at all, so I started lowering the dose.
I am not telling you what to do, but if you can add in exercise, or continue a structured workout program, you will probably find Tesa and MOTS-C to be game-changing additions. IMO, adding these in and not 1) eating enough and 2) exercising, will diminish the potential benefits of using them.
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Also, I totally understand the high stress job thing.
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If you are suffering a loss of energy while on Tirz, it may be because you aren’t eating enough. I know it is hard to do, but when I was above 7.5 mg tirz, I had to force myself to eat in order to hit my macros. At 10mg, I had no desire to eat at all, so I started lowering the dose.
I am not telling you what to do, but if you can add in exercise, or continue a structured workout program, you will probably find Tesa and MOTS-C to be game-changing additions. IMO, adding these in and not 1) eating enough and 2) exercising, will diminish the potential benefits of using them.
@ResearchCat I understand your concern. I'm eating plenty, trust me! I have other considerations, ex: I had an advanced case of Lyme Disease and 3 co-infections that took about 13 years (on & off) to get under control. Somewhere during that process, I lost 5.5' of bowel; to say I have absorption problems is an understatement, plus the MTHFR. There's a long laundry list my 70 yrs has collected. The energy loss started from the very beginning, but love the weight loss results. I think I'm probably taking NAD too many times per week, or too much. I cannot toss peps to the side, unless they're truly making me ill; my budget is so limited. Experimenting right now to find a good mix.
I definitely want to add Tesa and will just have to deal with more experimenting.
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Well, all this just kinda blows me out of the water. I need to get rid of a lot of visceral fat; I mean A LOT. The DEXA was horrible! I'm not that overweight, but the Dr. said, and I concur, it's been there a long time and I was raised on a Southern diet. I'm currently taking Tirzep once/wk on Friday night; nothing to eat since lunch, except very light snack later so stomach's not growling. NAD+ M,W & Sat, mornings upon waking, approx 10 hour fast. I have trouble sleeping and get up at 4:30, so not sure where to fit in Tesa. Question for all, but esp. for @randy Do Tesa and NAD+ work well together? I can cut back on the NAD, but not the Tirzep. I could also stay on lower does of Tesa for longer. What do y'all think?
@Eleanor Instead of Tesa you may want to try Survo with your Tirzepatide first. That with hit your glucagon receptor and cause you to burn fat for energy like a Reta effect. Also I ran 5 amino 1mq when I stalled and it helps with energy by blocking NAD loss
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@Eleanor Instead of Tesa you may want to try Survo with your Tirzepatide first. That with hit your glucagon receptor and cause you to burn fat for energy like a Reta effect. Also I ran 5 amino 1mq when I stalled and it helps with energy by blocking NAD loss
@beachfun Thanks for the idea! Does Survo target belly fat? What vendor do you like to research with? My weight hasn't really stalled, but the belly fat concentration is high. I'm fearful of Tesa because of the possibly of edema and joint pan; both of which I already have because of a desk job. Any additional might be unbearable, esp. at my age (70).
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Want to give a shoutout to Tesa from a 60-year-old male. I have been injecting 1mg Sun-Thurs for 12 weeks (among other things including Testosterone, Reta, GHK-Cu and Semax/Selank). Scan from yesterday showed a drop in visceral fat from 112 cm² to 70.3 cm² (37% reduction). Obviously, the Testosterone and Reta played a part, but I can definitively say it helped me. I'm a big fan. I'm taking a 2-week break and will start another cycle again. Can't say enough good things.
Want to give a shoutout to Tesa from a 60-year-old male. I have been injecting 1mg Sun-Thurs for 12 weeks (among other things including Testosterone, Reta, GHK-Cu and Semax/Selank). Scan from yesterday showed a drop in visceral fat from 112 cm² to 70.3 cm² (37% reduction). Obviously, the Testosterone and Reta played a part, but I can definitively say it helped me. I'm a big fan. I'm taking a 2-week break and will start another cycle again. Can't say enough good things.
What time of day of the injection? Thanks!
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I find it very curious (and awesome btw) that so many older people are experiencing such positive effects from tesamorelin. That tells me a couple things. First, it means the pituitary somatotrophs, even when in advanced age, can still function with proper exogenous help.
Second, that means other GHRH peptide drugs would work on those same people, because if Tesa is working (via GHRH stimulus) then the others must work to some (or full) extent as well.
The ongoing, and previously published tesa clinical data used many older patients, all with what should be a pretty harsh comorbitity all things considered (AIDS & advanced age) and despite this, produced a strong GHRH response from the pituitary. Same with the Sermorelin data from years past as well.
All this and I'm pretty sure the study participants were nowhere near as rigorous with there research as we are in terms of pinning around fasted times. I'm certain that none of the Sermorelin data participants even bothered with this at all (this was an unknown benefit at the time) and I don't think the Tesa participants did either but I'm not certain about that. Imagine how much better the results would have been had they made that a priority in their protocols.
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Want to give a shoutout to Tesa from a 60-year-old male. I have been injecting 1mg Sun-Thurs for 12 weeks (among other things including Testosterone, Reta, GHK-Cu and Semax/Selank). Scan from yesterday showed a drop in visceral fat from 112 cm² to 70.3 cm² (37% reduction). Obviously, the Testosterone and Reta played a part, but I can definitively say it helped me. I'm a big fan. I'm taking a 2-week break and will start another cycle again. Can't say enough good things.
What time of day of the injection? Thanks!
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