Tesamorelin Research Dosing Protocol
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I find it very curious (and awesome btw) that so many older people are experiencing such positive effects from tesamorelin. That tells me a couple things. First, it means the pituitary somatotrophs, even when in advanced age, can still function with proper exogenous help.
Second, that means other GHRH peptide drugs would work on those same people, because if Tesa is working (via GHRH stimulus) then the others must work to some (or full) extent as well.
The ongoing, and previously published tesa clinical data used many older patients, all with what should be a pretty harsh comorbitity all things considered (AIDS & advanced age) and despite this, produced a strong GHRH response from the pituitary. Same with the Sermorelin data from years past as well.
All this and I'm pretty sure the study participants were nowhere near as rigorous with there research as we are in terms of pinning around fasted times. I'm certain that none of the Sermorelin data participants even bothered with this at all (this was an unknown benefit at the time) and I don't think the Tesa participants did either but I'm not certain about that. Imagine how much better the results would have been had they made that a priority in their protocols.
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Want to give a shoutout to Tesa from a 60-year-old male. I have been injecting 1mg Sun-Thurs for 12 weeks (among other things including Testosterone, Reta, GHK-Cu and Semax/Selank). Scan from yesterday showed a drop in visceral fat from 112 cm² to 70.3 cm² (37% reduction). Obviously, the Testosterone and Reta played a part, but I can definitively say it helped me. I'm a big fan. I'm taking a 2-week break and will start another cycle again. Can't say enough good things.
What time of day of the injection? Thanks!
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@rburger01 I’m researching 2mg a day M-F. I use 2ml BAC in a 10mg vial. Daily dosage is 40 units.
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@rburger01
Tonight I am mixing up 4 vials into one cart with 3ml bac water and will research 14 units ~2mg/day.I research first thing after waking up (fasted) and typically don’t eat for 2 hours.
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@neil-mccauley I have researched Serm, Tesa, and CJC/Ipa and I can tell you with 100% certainty they work. I think the reason CJC/Ipa has the reputation and popularity it does is that you start noticing results in weeks, not months. Sermorelin is ‘gentler’ and takes months to notice a difference(great for revenue streams at the T clinic). I am only a few weeks into Tesa and have been injured so I can’t speak to results yet.
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Week 4 of Tesa and my Hume is telling me that my visceral fat index is up. Not sure exactly what that means. Will continue to monitor through the next month as I get back into a full workout schedule. After that will be cycling back to CJC/Ipa.
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I ordered from a vendor and they sent me 'free' sterile water with a note that said we reccomend sterile water instead of BAC. I am confused since I was going to use the 10mg within a week. So watching Randy's video, I should be fine and not have the thickening issue. Is this correct?
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I always use Hospira BAC for my Tes/Ipa and have never had a problem. I did a 12 week course this past winter and I am 4 weeks in on a 16 week course currently.
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I always use Hospira BAC for my Tes/Ipa and have never had a problem. I did a 12 week course this past winter and I am 4 weeks in on a 16 week course currently.
I always use Hospira BAC for my Tes/Ipa and have never had a problem. I did a 12 week course this past winter and I am 4 weeks in on a 16 week course currently.
16 weeks on the same bottle of bac?
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No I go through BAC fairly quickly with all of the other peps I do in that time. Probably from 3 different BACs.
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Just a quick update. I don’t know with certainty that it is from the Tesa, but since starting research, I have noticed not that my hands are swollen, but that they feel kind of swollen, if that makes sense, and my thumbs and wrists have been pretty sore. I’ve generally had more joint soreness as well despite continued KLOW research. I will give it another couple weeks but am likely going to accelerate the move back to CJC/Ipa, which was working very well for me.
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I get a puffy in the finger joints feeling from both, but feel it more so with tesa. It does not make physiological sense unless the GH pulse is higher with tesa. Probably largely my imagination but it's the main reason why I run CJC/Ipa. Never compared Igf levels between the two so who knows.
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Just a quick update. I don’t know with certainty that it is from the Tesa, but since starting research, I have noticed not that my hands are swollen, but that they feel kind of swollen, if that makes sense, and my thumbs and wrists have been pretty sore. I’ve generally had more joint soreness as well despite continued KLOW research. I will give it another couple weeks but am likely going to accelerate the move back to CJC/Ipa, which was working very well for me.
@ResearchCat I don't have any experience on Tesa but I've read and talked to people that said it causes water retention and sometimes joint pain.
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Im really struggling with Tesa over CJC. It requires much higher dosing (like 8x more expensive just based on 250mcg vs 2mg dosing), is less stable in the vial from what I gather, and essentially does the same thing.
Is it the FDA approval? I know it is hailed as the 'visceral fat' pick for these GHRH analogs but the reason for that is because it was tested for it...the others are going to do the same thing, which is getting the downstream IGF-1 boost.
What am I missing?
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Nope, you nailed it. People do it for the visceral fat. IMO, If you tolerate it well, CJC/IPA is the answer.
Yeah, well, I’m just here for the research, man. - The Dude
If I haven’t liked your post, no offense. I have exceeded my daily allowance.
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Nope, you nailed it. People do it for the visceral fat. IMO, If you tolerate it well, CJC/IPA is the answer.
@hunt_ak Tesamorelin is claimed to be effective for visceral fat because it was FDA-approved for that purpose, so there were studies confirming it. But all it is - a slightly modified 44-amino-acid Growth Hormone-Releasing Hormone (GHRH). CJC-1295 is also, a slightly modified 29-amino-acid fragment of the same GHRH hormone (while Sermorelin is 1-29 unmodified fragment, btw). So, it's smaller, which means more molecules per mg, and it may be as effective in smaller doses. CJC-1295 wasn't tested for visceral fat as much as Tesamorelin, not that it would fail the testing. It could be as effective or even more effective than Tesamorelin, we just don't have the trials.
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I saw an influencer state that due to the length of the amino chain structure of Tesa being longer than most peptides, that it should be stored at room temperature and used within 7 days. He was saying that due to the length it has a tendency to fold on itself, and refrigeration makes that more likely. Sounded convincing, but so does a lot of things that aren't necessarily true.
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@hunt_ak Tesamorelin is claimed to be effective for visceral fat because it was FDA-approved for that purpose, so there were studies confirming it. But all it is - a slightly modified 44-amino-acid Growth Hormone-Releasing Hormone (GHRH). CJC-1295 is also, a slightly modified 29-amino-acid fragment of the same GHRH hormone (while Sermorelin is 1-29 unmodified fragment, btw). So, it's smaller, which means more molecules per mg, and it may be as effective in smaller doses. CJC-1295 wasn't tested for visceral fat as much as Tesamorelin, not that it would fail the testing. It could be as effective or even more effective than Tesamorelin, we just don't have the trials.
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