Thymulin Research thus far
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I've been on a quest to find a treatment/complementary RA treatment for my lab rat since December. Did a few cycles of TA-1, subtle effects. Took a step back, did more research and found Thymulin, there are clinical studies, and it's was used in RA studies. Figured I'd add TA-1 back in after a month.
So, I picked up 4 vials, began my research 2 weeks ago, low and slow. .5mg titrated up to 3.5mg. BUT one very important thing I missed/mixed-up, was the protocol I should be be following: Protocol A vs Protocol B. I was using Protocol B, 1mg daily for 30 days. For RA research, Protocol A should be used, which is a whole different ball game. 5mg daily for 3-6 months!! This is going to get very expensive, and not a lot of vendors carry it.
My decisions just got more complicated.
There's that old saying: “The more I learn, the more I realize I haven’t learned"
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Studies use HIGH therapeutic doses to evaluate if it merits further study and to assess “harm”. In my past research I have been able to conclude the same results as the study using half the dose. My personal example is ARA was studied at 4mg for 30 days, I achieve similar results with 2mg.
Another example is the various glp studies. Many have achieved results at the starting doses without going up to the higher doses the peptide was originally studied at. After the initial high mg studies to asses “harm” there was follow-up studies at lower doses that showed results but at a slower pace, which is the protocol many follow now. -
@PeptideEd said in Thymulin Research thus far:
@wisgal64 where are you getting your Thymulin?
Southern Aminos and BioLongevity. I just found some at Skye Peptides as well. I do like Skye's lineup, the price is decent.
Edit: Looking at their CoA, it's dated back to Sept 25, I'm guessing they may not get many orders for it? But it does raise another question, how old is considered too old for a CoA?
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Studies use HIGH therapeutic doses to evaluate if it merits further study and to assess “harm”. In my past research I have been able to conclude the same results as the study using half the dose. My personal example is ARA was studied at 4mg for 30 days, I achieve similar results with 2mg.
Another example is the various glp studies. Many have achieved results at the starting doses without going up to the higher doses the peptide was originally studied at. After the initial high mg studies to asses “harm” there was follow-up studies at lower doses that showed results but at a slower pace, which is the protocol many follow now.@MyB said in Thymulin Research thus far:
Studies use HIGH therapeutic doses to evaluate if it merits further study and to assess “harm”. In my past research I have been able to conclude the same results as the study using half the dose. My personal example is ARA was studied at 4mg for 30 days, I achieve similar results with 2mg.
Another example is the various glp studies. Many have achieved results at the starting doses without going up to the higher doses the peptide was originally studied at. After the initial high mg studies to asses “harm” there was follow-up studies at lower doses that showed results but at a slower pace, which is the protocol many follow now.These are good points.
ARA worked great for me for the nerve pain at 2mg. Never went any higher. I'll hold steady at 3.5mg for a couple of weeks, and assess.Edit: the clinical studies are old according to Peptidewiki, they say:
The Logic: Studies comparing 1mg, 5mg, and 10mg found that 5mg was the “sweet spot.” It provided the maximum reduction in joint swelling without added benefit from going higher.
I'm going my sweet spot is lower
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Good grief, I just went to place an order with Southern, because it's back in stock. On Feb 22, it was $90 retail price, used a discount code so it was less. Anyway, this morning, checked to see if it was back in stock, ohh it's back in stock, BUT, the retail price is now $154, sale price is $115.50???
I realize they upped their testing, but a $64 increase(25.50 for sale price)? HARD pass for me
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Well, I decided to halt this project for now, too expensive and my lab rat wasn't experiencing anything meaningful after 4 vials, there are no leaves left on my tree for finding that sweet spot, at least until I can find a vendor who is offering better prices. A Thymalin +TA1 is in a future project, more affordable.
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PGB had THY-10 for $60 as recently as a couple of weeks ago, although they appear to be out of stock for now. An interesting vendor, has some hard to find stuff like P21 (I haven't found another vendor that has this).
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PGB had THY-10 for $60 as recently as a couple of weeks ago, although they appear to be out of stock for now. An interesting vendor, has some hard to find stuff like P21 (I haven't found another vendor that has this).
@bangkokiscool said in Thymulin Research thus far:
PGB had THY-10 for $60 as recently as a couple of weeks ago, although they appear to be out of stock for now. An interesting vendor, has some hard to find stuff like P21 (I haven't found another vendor that has this).
OMG that price, wow. Do they have a site? or TG?
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Yes very good price especially for 10 vials. https://pgbmemberpass.com/ and COA info is at https://support.pgb.shipsync.pro/portal/en/kb/pgb/product-information
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Yes very good price especially for 10 vials. https://pgbmemberpass.com/ and COA info is at https://support.pgb.shipsync.pro/portal/en/kb/pgb/product-information
@bangkokiscool said in Thymulin Research thus far:
Yes very good price especially for 10 vials. https://pgbmemberpass.com/ and COA info is at https://support.pgb.shipsync.pro/portal/en/kb/pgb/product-information
Thank you
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If you talk about Thymulin, 9-amino acid (nonapeptide), or as it is also called, FTS, see this article https://peptideinitiative.com/peptides/thymulin-fts
The research dosage is quite low, very effective from 100 mcg. However, it is often used in a lot higher doses, partially because people confuse it with "Thymalin" - which is in literature a naturally extracted thymic compound https://peptideinitiative.com/peptides/thymalin , and people use dosages from it, but Thymalin is a different compound and likely does not even include Thymulin.
Also, Thymulin in low dosage sometimes may (strangely enough) cause a side effect (an increased reaction to any kind of pain), and in higher doses this side effect is absent. It is considered safe even in 10 mg doses or more, but may be just a waste of money.
Also, make sure to get it from a better vendor, as I had a bad experience with one popular vendor, that even publishes Janoshik COAs on it (only purity though), and it causes very bad systemic reactions (to my lab rat) even in 300 mcg doses. At least make sure you have tests on purity, quantity, endotoxins, microbial activity, and it's good to also test heavy metals. -
If you talk about Thymulin, 9-amino acid (nonapeptide), or as it is also called, FTS, see this article https://peptideinitiative.com/peptides/thymulin-fts
The research dosage is quite low, very effective from 100 mcg. However, it is often used in a lot higher doses, partially because people confuse it with "Thymalin" - which is in literature a naturally extracted thymic compound https://peptideinitiative.com/peptides/thymalin , and people use dosages from it, but Thymalin is a different compound and likely does not even include Thymulin.
Also, Thymulin in low dosage sometimes may (strangely enough) cause a side effect (an increased reaction to any kind of pain), and in higher doses this side effect is absent. It is considered safe even in 10 mg doses or more, but may be just a waste of money.
Also, make sure to get it from a better vendor, as I had a bad experience with one popular vendor, that even publishes Janoshik COAs on it (only purity though), and it causes very bad systemic reactions (to my lab rat) even in 300 mcg doses. At least make sure you have tests on purity, quantity, endotoxins, microbial activity, and it's good to also test heavy metals.@vpeptides said in Thymulin Research thus far:
If you talk about Thymulin, 9-amino acid (nonapeptide), or as it is also called, FTS, see this article https://peptideinitiative.com/peptides/thymulin-fts
The research dosage is quite low, very effective from 100 mcg. However, it is often used in a lot higher doses, partially because people confuse it with "Thymalin" - which is in literature a naturally extracted thymic compound https://peptideinitiative.com/peptides/thymalin , and people use dosages from it, but Thymalin is a different compound and likely does not even include Thymulin.
Also, Thymulin in low dosage sometimes may (strangely enough) cause a side effect (an increased reaction to any kind of pain), and in higher doses this side effect is absent. It is considered safe even in 10 mg doses or more, but may be just a waste of money.
Also, make sure to get it from a better vendor, as I had a bad experience with one popular vendor, that even publishes Janoshik COAs on it (only purity though), and it causes very bad systemic reactions (to my lab rat) even in 300 mcg doses. At least make sure you have tests on purity, quantity, endotoxins, microbial activity, and it's good to also test heavy metals.I've reviewed studies on it. Specifically for the RA protocol. Experiences won't be the same across research. I haven't read peptideinitiative, but reviewed others, e.g. peptidewiki. Hyperalgesia was definitely a concern, but with the dosage amount, in the protocol I was following it was less of a concern.
It's interesting, because I've come across multiple vendors who market Thymulin, but what they are actually selling is Thymalin, CoA prove it. It's something I've pointed out to a few, because there is a difference between the 2 is my understanding from all of the literature I've read, including how they are manufactured.
From my notes:
Thanks for sharing the resource, I'll have a look at it.
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Agree, many vendors seem like to have no clue how to name it. I had a conversation with limitlesslifenootropics which is generally a very good source, and they insisted that their Thymalin is synthetic and their Thymulin (they sell both) is thymus-derived. But the formula they provided are the same, both seem to be tested to be a 9-peptide. Go figure. Others just sell Thymulin marked as Thymalin (for increased sales, I guess).
That "Thymalin" you quoted is a thymus-derived compound, having Vilon (as the main peptide) and also Thymogen, Crystagen, etc., all in 1%-5% proportions. No Thymulin there.
Anyway, be sure to take Zinc 20-50 mg (2 hours before if orally).
I would be careful about that mentioned PGB. They look suspicious to me.
Beyond Limitless, if you figure out what they sell, (their thymalin 100mg is 126.49 now), there is canlabintl, but it kind of expensive, and they don't publish COA so you have to trust. Also BioEdge has it 45$/10mg and they tested for endotoxins.
