Nasal PT-141

[Anthony]

I’m interested in researching with PT-141 and have heard some instances of using it mixed in a nasal solution. Does anyone have any experience or feedback with this method? I am thinking it would just be one less injection into the rat and more discrete also. Thanks!

[melissasutton]

I tried the nasal spray that was already prepared from a vendor and it did not do anything for me. Tried it a couple times and then threw it away. I am a female though so maybe it's different for men

[MyB]

The molecular weight of PT-141 is larger than 500 daltons, making it ineffective as a nasal spray. Molecular weights 300 and under work best when no carrier for absorption is used. Molecular size is mentioned on page 18 of 21 on this pdf.
https://wjbphs.com/sites/default/files/fulltext_pdf/WJBPHS-2025-0913.pdf

[Anthony]

@MyB Thank you, that is exactly the information I was looking for, much appreciated!!

[hunt_ak]

@anthony did you have any updated experience with the PT-141? I've tried 3 separate instances sub-q (500mc and twice at 1mg) and nada...absolutely zero response it seemed

[gym.rat]

I've never used the product, but the amount of anecdotal evidence I've come across bashing the nasal as useless is so overwhelming that I find it 100% convincing.

[vpeptides]

Pt-141 is basically the same as melanotan-2 - a 7-aa-ring-shaped peptide. It might make it really hard to be absorbed that way.