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MOTS-C: Dosing & Blood Pressure Meds

Scheduled Pinned Locked Moved Peptide Discussion
mots-cdosage-discussionother-peptide
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  • E Offline
    E Offline
    Eleanor
    wrote last edited by
    #1

    Looking for some deals on MOTS-C for early Fall use (after I finish current protocols) but have some questions that you fine, experienced folks might be able to answer.

    Using link below:
    https://peptideinitiative.com/peptides/mots-c

    It states a possible effect on blood pressure. Does anyone know if this is a lowering of BP or rise in BP? I have high BP.

    Do those who have a plethora of experience with this recommend the starting dose stated?

    Does it sting? I like extra BAC for stingers.

    Thank you for your kind attention while busy hunting bargains.

    gym.ratG 1 Reply Last reply
    0
    • EXTROPIANE Away
      EXTROPIANE Away
      EXTROPIAN
      wrote last edited by EXTROPIAN
      #2

      Not sure on the degree of your blood pressure. Notnsure if youre on Ace inhibitors, beta blockers... If youre committing to optimize mitochondria? I would try Co-Q10 and Methylene Blue first. Still considering your blood pressure. You need to lower your inflation first. Foundation first and then you can consider researching with peptides on your own.

      "The truth about hypertension" Dr Trevor Backmeyer

      E 1 Reply Last reply
      0
      • EXTROPIANE EXTROPIAN

        Not sure on the degree of your blood pressure. Notnsure if youre on Ace inhibitors, beta blockers... If youre committing to optimize mitochondria? I would try Co-Q10 and Methylene Blue first. Still considering your blood pressure. You need to lower your inflation first. Foundation first and then you can consider researching with peptides on your own.

        "The truth about hypertension" Dr Trevor Backmeyer

        E Offline
        E Offline
        Eleanor
        wrote last edited by
        #3

        @martinmarin said:

        Not sure on the degree of your blood pressure. Notnsure if youre on Ace inhibitors, beta blockers... If youre committing to optimize mitochondria? I would try Co-Q10 and Methylene Blue first. Still considering your blood pressure. You need to lower your inflation first. Foundation first and then you can consider researching with peptides on your own.

        Thank you for your reply. I think you mean my inflammation, which is well lowered. I'm researching SS-31 before MOTS-C. I really have no interest in Co-Q10 or MBlue. I have a personal program I'm trying to follow. Think I will go with 1/2 doses and monitor BP. Thanks much!

        EXTROPIANE 1 Reply Last reply
        1
        • FalcF Offline
          FalcF Offline
          Falc
          wrote last edited by Falc
          #4

          I have been "diagnosed" with chronic hypertension, I am on week 9 of a 12-week cycle of MOTS-c daily at 1mg (M-F), and I have not noticed any increase of my baseline BP average since starting the MOTS-c. No sting at all for me, I usually pen it in the quad.

          E 1 Reply Last reply
          2
          • FalcF Falc

            I have been "diagnosed" with chronic hypertension, I am on week 9 of a 12-week cycle of MOTS-c daily at 1mg (M-F), and I have not noticed any increase of my baseline BP average since starting the MOTS-c. No sting at all for me, I usually pen it in the quad.

            E Offline
            E Offline
            Eleanor
            wrote last edited by
            #5

            @Falc Thanks Falc, I appreciate the information.

            1 Reply Last reply
            0
            • EXTROPIANE Away
              EXTROPIANE Away
              EXTROPIAN
              wrote last edited by
              #6
              This post is deleted!
              1 Reply Last reply
              0
              • Hammertime65H Offline
                Hammertime65H Offline
                Hammertime65
                wrote last edited by
                #7

                I take Amlodipine, Chlorthalidone and dropped Lisinopril and spironolactone while running mots. My blood pressure has stayed the same. I've dropped 78 pounds so that helps also.

                E 1 Reply Last reply
                0
                • Hammertime65H Hammertime65

                  I take Amlodipine, Chlorthalidone and dropped Lisinopril and spironolactone while running mots. My blood pressure has stayed the same. I've dropped 78 pounds so that helps also.

                  E Offline
                  E Offline
                  Eleanor
                  wrote last edited by
                  #8

                  @Hammertime65
                  Dropping the weight IMO helps more than anything; Dr's can rx overdose, one size fits all. I cut my BP rx's in half. Lisinopril was a real problem with a hacking cough that developed only one month after I started it; sounded like I was barking up a lung.

                  1 Reply Last reply
                  0
                  • E Eleanor

                    Looking for some deals on MOTS-C for early Fall use (after I finish current protocols) but have some questions that you fine, experienced folks might be able to answer.

                    Using link below:
                    https://peptideinitiative.com/peptides/mots-c

                    It states a possible effect on blood pressure. Does anyone know if this is a lowering of BP or rise in BP? I have high BP.

                    Do those who have a plethora of experience with this recommend the starting dose stated?

                    Does it sting? I like extra BAC for stingers.

                    Thank you for your kind attention while busy hunting bargains.

                    gym.ratG Online
                    gym.ratG Online
                    gym.rat
                    wrote last edited by gym.rat
                    #9

                    @Eleanor I can tell you right now I would throw that website in the trash. Right off the bat it says to use 5mg dose of MOTS-c which is 100% off the rocker nonsense. Zero credibility and I wouldn't touch any piece of info from there. MOTS-c can send you to the hospital if not careful. Certain people should NOT touch it. It makes me so mad there is such bad info out there. TRASH IT!

                    I've sent you this link before, but use it. The info here is correct, frequently updated and heavily researched. No stone unturned. https://peptideprotocols.app/peptides/mots-c

                    For all those in the peanut gallery, if you are taking MOTS-c start small and work your way up. If you have a history of histamine reactions I would not use this pep or proceed with extreme caution. Reactions are more common with this pep than any other I have researched and anaphylactic shock while rare is a possibility. Hives are unfortunately more common than you'd like as well. Don't recon it with BAC water either. All this info is present on the site above. Read before you pin people!!!

                    Data collector for https://peptideprotocols.app/

                    E 2 Replies Last reply
                    1
                    • gym.ratG gym.rat

                      @Eleanor I can tell you right now I would throw that website in the trash. Right off the bat it says to use 5mg dose of MOTS-c which is 100% off the rocker nonsense. Zero credibility and I wouldn't touch any piece of info from there. MOTS-c can send you to the hospital if not careful. Certain people should NOT touch it. It makes me so mad there is such bad info out there. TRASH IT!

                      I've sent you this link before, but use it. The info here is correct, frequently updated and heavily researched. No stone unturned. https://peptideprotocols.app/peptides/mots-c

                      For all those in the peanut gallery, if you are taking MOTS-c start small and work your way up. If you have a history of histamine reactions I would not use this pep or proceed with extreme caution. Reactions are more common with this pep than any other I have researched and anaphylactic shock while rare is a possibility. Hives are unfortunately more common than you'd like as well. Don't recon it with BAC water either. All this info is present on the site above. Read before you pin people!!!

                      E Offline
                      E Offline
                      Eleanor
                      wrote last edited by
                      #10

                      @gym.rat Thank you! I was actually looking for the link you have posted above. Less is always better as far as I'm concerned. If the starting dose is 1mg, it's 500mcg for me. Thank you very much!

                      gym.ratG 1 Reply Last reply
                      0
                      • gym.ratG gym.rat

                        @Eleanor I can tell you right now I would throw that website in the trash. Right off the bat it says to use 5mg dose of MOTS-c which is 100% off the rocker nonsense. Zero credibility and I wouldn't touch any piece of info from there. MOTS-c can send you to the hospital if not careful. Certain people should NOT touch it. It makes me so mad there is such bad info out there. TRASH IT!

                        I've sent you this link before, but use it. The info here is correct, frequently updated and heavily researched. No stone unturned. https://peptideprotocols.app/peptides/mots-c

                        For all those in the peanut gallery, if you are taking MOTS-c start small and work your way up. If you have a history of histamine reactions I would not use this pep or proceed with extreme caution. Reactions are more common with this pep than any other I have researched and anaphylactic shock while rare is a possibility. Hives are unfortunately more common than you'd like as well. Don't recon it with BAC water either. All this info is present on the site above. Read before you pin people!!!

                        E Offline
                        E Offline
                        Eleanor
                        wrote last edited by
                        #11

                        @gym.rat Do you have a favored site where you like to buy BAC saline?

                        gym.ratG 1 Reply Last reply
                        0
                        • E Offline
                          E Offline
                          Eleanor
                          wrote last edited by Eleanor
                          #12

                          Found it.
                          https://peptidetest.com/products/pfizer-hospira-bacteriostatic-sodium-chloride-for-injection-30-ml?_pos=1&_sid=321b006db&_ss=r
                          Looks like I probably need to wait until cooler weather to order this, per peptide test instructions that it might be more unstable that regular BAC.

                          gym.ratG 1 Reply Last reply
                          1
                          • E Eleanor

                            @gym.rat Do you have a favored site where you like to buy BAC saline?

                            gym.ratG Online
                            gym.ratG Online
                            gym.rat
                            wrote last edited by gym.rat
                            #13

                            @Eleanor Yes, I get all my Hospira BAC from peptidetest.com. Zero issues and good pricing. Been ordering from them for the last 12 months or so. In fact I just placed an order the other day b/c I'm about to do a cycle of SS-31 myself starting manana. Screenshot 2026-07-04 at 1.28.56 AM.png

                            Data collector for https://peptideprotocols.app/

                            E 1 Reply Last reply
                            1
                            • E Eleanor

                              Found it.
                              https://peptidetest.com/products/pfizer-hospira-bacteriostatic-sodium-chloride-for-injection-30-ml?_pos=1&_sid=321b006db&_ss=r
                              Looks like I probably need to wait until cooler weather to order this, per peptide test instructions that it might be more unstable that regular BAC.

                              gym.ratG Online
                              gym.ratG Online
                              gym.rat
                              wrote last edited by
                              #14

                              @Eleanor The product will be fine, just don't let it sit on your porch or in your mailbox unattended. I make sure I'm home the minute it arrives and off it goes to a room temp dark place.

                              Data collector for https://peptideprotocols.app/

                              E 1 Reply Last reply
                              0
                              • E Eleanor

                                @gym.rat Thank you! I was actually looking for the link you have posted above. Less is always better as far as I'm concerned. If the starting dose is 1mg, it's 500mcg for me. Thank you very much!

                                gym.ratG Online
                                gym.ratG Online
                                gym.rat
                                wrote last edited by
                                #15

                                @Eleanor When it comes to MOTS-c, you want to do the repair phase with SS-31 either first or with MOTS-c. They are synergetic. I personally prefer to get 2-3 weeks into an 8 week SS-31 cycle and then add MOTS-c on top M - W - F. I start MOTS-c at 500mcg myself. It's just not a pep I like to screw around with and then slowly titrate up. The goal is to get around or close to 10mg a week once your body adjusts, meaning work up to 3mg a pin. Bacteriostatic saline (0.9% sodium chloride with benzyl alcohol) is a must in my book for MOTS recon. Its isotonic formulation may help reduce injection-site redness, swelling, itching, welts, or hives in sensitive users. For the 45 or so peps I track, MOTS-c has the highest ratio in a side effect profile and the funny thing is those sides (hives or rashes) often come several weeks into the cycle. So far I have not yet come across these side effects with BAC saline, but its still a smaller sample size comparatively.

                                Data collector for https://peptideprotocols.app/

                                S E 3 Replies Last reply
                                3
                                • gym.ratG gym.rat

                                  @Eleanor When it comes to MOTS-c, you want to do the repair phase with SS-31 either first or with MOTS-c. They are synergetic. I personally prefer to get 2-3 weeks into an 8 week SS-31 cycle and then add MOTS-c on top M - W - F. I start MOTS-c at 500mcg myself. It's just not a pep I like to screw around with and then slowly titrate up. The goal is to get around or close to 10mg a week once your body adjusts, meaning work up to 3mg a pin. Bacteriostatic saline (0.9% sodium chloride with benzyl alcohol) is a must in my book for MOTS recon. Its isotonic formulation may help reduce injection-site redness, swelling, itching, welts, or hives in sensitive users. For the 45 or so peps I track, MOTS-c has the highest ratio in a side effect profile and the funny thing is those sides (hives or rashes) often come several weeks into the cycle. So far I have not yet come across these side effects with BAC saline, but its still a smaller sample size comparatively.

                                  S Offline
                                  S Offline
                                  Stevepep
                                  wrote last edited by
                                  #16

                                  @gym.rat super helpful I really want to try MotsC on a future cycle.

                                  1 Reply Last reply
                                  0
                                  • E Eleanor

                                    @martinmarin said:

                                    Not sure on the degree of your blood pressure. Notnsure if youre on Ace inhibitors, beta blockers... If youre committing to optimize mitochondria? I would try Co-Q10 and Methylene Blue first. Still considering your blood pressure. You need to lower your inflation first. Foundation first and then you can consider researching with peptides on your own.

                                    Thank you for your reply. I think you mean my inflammation, which is well lowered. I'm researching SS-31 before MOTS-C. I really have no interest in Co-Q10 or MBlue. I have a personal program I'm trying to follow. Think I will go with 1/2 doses and monitor BP. Thanks much!

                                    EXTROPIANE Away
                                    EXTROPIANE Away
                                    EXTROPIAN
                                    wrote last edited by EXTROPIAN
                                    #17

                                    @Eleanor Well if youre all in then MOTSC and NAD+ definitely to get the engines running. As soon as you get going in between the cycle throw in SS31. MOTSC signal what to do. NAD+ is the fuel to all mitochondria. SS31 repairs. A car analogy- You need a driver on board to to drive step on the pedal (MOTSC). You need the proper fuel (NAD+). Need a mechanic to repair and patch up the car and engine SS31. The engine cannot be repaired without a driver on low to no fuel? As far as I am concern there isn't anything left to move the needle but mitochondria. Give what you have of mitochondria to run the best they can. Then start repairing. All three do way more then what I described. When you get all three or along the way you will start Mitochondrial biogenesis (make more mitochondria). If you later wants to level up you can clears out dead mitochondria via a cellular process called mitochondria mitophagy by doing a MOTSC, NAD+ and Humanin. Personally I never done it but Humanin is in bucket list of peps. Man there are so many like FOXO4-p53, CRUNCH and of course NAD that clean up dead cells.

                                    Here is a video of this guy who did a cleaning along the way. There are alot of jewels in there. All including Mitochondria optimizations and cleaning with peptides.

                                    https://youtu.be/2SETwRnzvrw?is=Wmi5CvC4wPZoQ7Re

                                    1 Reply Last reply
                                    0
                                    • gym.ratG gym.rat

                                      @Eleanor When it comes to MOTS-c, you want to do the repair phase with SS-31 either first or with MOTS-c. They are synergetic. I personally prefer to get 2-3 weeks into an 8 week SS-31 cycle and then add MOTS-c on top M - W - F. I start MOTS-c at 500mcg myself. It's just not a pep I like to screw around with and then slowly titrate up. The goal is to get around or close to 10mg a week once your body adjusts, meaning work up to 3mg a pin. Bacteriostatic saline (0.9% sodium chloride with benzyl alcohol) is a must in my book for MOTS recon. Its isotonic formulation may help reduce injection-site redness, swelling, itching, welts, or hives in sensitive users. For the 45 or so peps I track, MOTS-c has the highest ratio in a side effect profile and the funny thing is those sides (hives or rashes) often come several weeks into the cycle. So far I have not yet come across these side effects with BAC saline, but its still a smaller sample size comparatively.

                                      S Offline
                                      S Offline
                                      Stevepep
                                      wrote last edited by
                                      #18

                                      @gym.rat What does of ss-31 the doses seem so high

                                      gym.ratG 1 Reply Last reply
                                      0
                                      • gym.ratG gym.rat

                                        @Eleanor Yes, I get all my Hospira BAC from peptidetest.com. Zero issues and good pricing. Been ordering from them for the last 12 months or so. In fact I just placed an order the other day b/c I'm about to do a cycle of SS-31 myself starting manana. Screenshot 2026-07-04 at 1.28.56 AM.png

                                        E Offline
                                        E Offline
                                        Eleanor
                                        wrote last edited by
                                        #19

                                        @gym.rat said:

                                        @Eleanor Yes, I get all my Hospira BAC from peptidetest.com. Zero issues and good pricing. Been ordering from them for the last 12 months or so. In fact I just placed an order the other day b/c I'm about to do a cycle of SS-31 myself starting manana. Screenshot 2026-07-04 at 1.28.56 AM.png

                                        Ok, well, it's 97 degrees here and up to 90% humidity. Most items delivered during height of heat and I don't get home until 6pm.

                                        1 Reply Last reply
                                        0
                                        • gym.ratG gym.rat

                                          @Eleanor When it comes to MOTS-c, you want to do the repair phase with SS-31 either first or with MOTS-c. They are synergetic. I personally prefer to get 2-3 weeks into an 8 week SS-31 cycle and then add MOTS-c on top M - W - F. I start MOTS-c at 500mcg myself. It's just not a pep I like to screw around with and then slowly titrate up. The goal is to get around or close to 10mg a week once your body adjusts, meaning work up to 3mg a pin. Bacteriostatic saline (0.9% sodium chloride with benzyl alcohol) is a must in my book for MOTS recon. Its isotonic formulation may help reduce injection-site redness, swelling, itching, welts, or hives in sensitive users. For the 45 or so peps I track, MOTS-c has the highest ratio in a side effect profile and the funny thing is those sides (hives or rashes) often come several weeks into the cycle. So far I have not yet come across these side effects with BAC saline, but its still a smaller sample size comparatively.

                                          E Offline
                                          E Offline
                                          Eleanor
                                          wrote last edited by
                                          #20

                                          @gym.rat Understand and agree! I appreciate your help, I really do. I'm so tired; this is the first real time I've had off in 2 years. so...gotta do something. I plan to do SS31 & MOTSC separately.

                                          gym.ratG 1 Reply Last reply
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