SS-31 Virgins. If it's your first time taking SS-31, please post.
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What I'm learning about SS-31:
There are researchers who ask if it's worth the price, or say it's not working, and a myriad of other things. Let me just say that IMO, if you're under 50 yoa and NOT mito compromised with chemotherapy or heavy antibiotic or anti protozoan treatment, etc. it is NOT worth it.
Quite frankly, you just might need some NAD+ (buffered), if your diet is wrong, or, you're stressing yourself in some way. It will take 2 to 4 weeks to really tell if you take it every other day.
SS31 - Most 'community' protocols advocate up to 8 weeks daily, I beg to differ; it's closer to 12 to 16 weeks. I'm on week 9 now and plan to take the 12-16 weeks. The fact is, I might not know how well it's worked, or worked at all until I stop the protocol and just stay with NAD+BUFFERED (can't stress that enough). Time is the factor, as well as a reasonable dose, which does not mean 10+mg or 40mg. TIME is the factor that most people are not giving some of these peps. Depending upon your body weight, I would not go over 4mg daily; you don't need to do that and it's expensive. TIME is the factor with SS31, maybe Cartalax and others; maybe a bit sooner, but not much.
Please do NOT take MOTS-C with SS-31; wait until your done, else you're just muddying the waters and can't be sure if the SS31 worked for you or not. I know that's counter to what's written, but you're just wasting money, time and will eventually claim SS31 doesn't work, which might not be true. I am thoroughly convinced that time is the factor. 12 to 16 weeks. Yes, you can take some 'helper peps'; TA-1 is good, as it's thymus related and might help. NAD+ is good. Again, after you stop at the end of the protocol time is when you'll really find out what's worked.
A few things I'd definitely take along with helper peps (if you so choose) is a complete vit. C and a METHYLATED complete vit. B. Do not take unmethylated B; no 'cyano' anything, no folic acid, it needs to be methylfolate.
I will always take NAD+. I didn't think it would work at first, but after the 2nd week, what a difference it made, but I am (hopefully 'was') pretty mito compromised, so, will see.
12 to 16 weeks, otherwise, it's a waste. I will honestly let you know if I think SS-31 has done anything for me a month or so after stopping, but I'm convinced...It takes a longer duration than the popular protocols state.
Make of this what you will.
I’ll comment on some community “protocol” bullshit. I got nothing out of it I could point to until AFTER I went above 5mg. Went rapidly to 10 after that and now I’m on 20mg/day. I CAN DEFINITELY TELL it’s working above 10mg. Don’t fall for the “well it takes a while to do its job and correct the system “. If you’ve already done a month below 10mg you have gotten things systemically as far as they can go at those levels.
Hit that 10-20mg range and discover what this stuff will really do for you. Huge difference in effect.
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I’ll comment on some community “protocol” bullshit. I got nothing out of it I could point to until AFTER I went above 5mg. Went rapidly to 10 after that and now I’m on 20mg/day. I CAN DEFINITELY TELL it’s working above 10mg. Don’t fall for the “well it takes a while to do its job and correct the system “. If you’ve already done a month below 10mg you have gotten things systemically as far as they can go at those levels.
Hit that 10-20mg range and discover what this stuff will really do for you. Huge difference in effect.
I read some chatter about these wicked high doses from some bodybuilders a while back and was hoping someday to try 100mg. However, my first week on 5mg SS-31 was profound -- I could not mix it with caffeine!
I think the community protocols are a good safety net for starting, but yeah, with peptides the operative word is individual "research." -
I’ll comment on some community “protocol” bullshit. I got nothing out of it I could point to until AFTER I went above 5mg. Went rapidly to 10 after that and now I’m on 20mg/day. I CAN DEFINITELY TELL it’s working above 10mg. Don’t fall for the “well it takes a while to do its job and correct the system “. If you’ve already done a month below 10mg you have gotten things systemically as far as they can go at those levels.
Hit that 10-20mg range and discover what this stuff will really do for you. Huge difference in effect.
@ogsteve This is interesting, thanks for the input. I'm waiting on more ss-31 now, I did about 18 weeks on but never went above 3.5mg daily. Maybe I've noticed less energy while not taking, but also not sure. When I start again I'll try 5-10 next go round, after about a month off. I guess I'm pretty conservative (skeered?
)with all my dosing, except for NAD - I do 100 - 150 because I can certainly tell what that's doing. -
I’ll comment on some community “protocol” bullshit. I got nothing out of it I could point to until AFTER I went above 5mg. Went rapidly to 10 after that and now I’m on 20mg/day. I CAN DEFINITELY TELL it’s working above 10mg. Don’t fall for the “well it takes a while to do its job and correct the system “. If you’ve already done a month below 10mg you have gotten things systemically as far as they can go at those levels.
Hit that 10-20mg range and discover what this stuff will really do for you. Huge difference in effect.
@ogsteve Thanks for letting us know what's working for you. 5mg. for me is not out of the question; maybe a tad more. At this point, it's a matter of progress v. expense and the combo of NAD+ & MOTS-C has produced major improvement in energy. Could be that even smaller doses of SS31 were helpful in assisting with those mechanisms. Probably won't know for a while.
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So iv3 started my first mitochondrial journey starting with ss31 at 5mg daily as we get closer to the end of that we will bridge to motsc then bridge to 5amino then get the nad+ going.
My ss31 experience has been very light but noticeable the first couple days me and my lady were exhausted by the 4th day I felt a bit of an uptick in energy, nothing insanely substantial. From my understanding ss31 helps to repair and renew cells so probably not much to notice but it is a great place to start on the mitochondrial repair path. At least this is what ive gathered so far
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Just start SS-31 today. First does 4mg in the morning, empty stomach, not sure if that is really going to matter. Here is the plan, ensue comments:
- SS-31 - Daily 4mg for 6 weeks
- NAD+ 25mg Monday and Thursday for 2 weeks
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- increase to 50mg for 2 weeks, then 100mg for two weeks.
Second day of SS-31 @ 4mg, not too much to notice. Little ichy, took some antihistamine. Took NAD+ @ 25mg. I did notice this, 24ui, red dot right away, felt stomach move with in 10minutes, and felt a kindof light headedness. This should be an interesting protocol
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I read some chatter about these wicked high doses from some bodybuilders a while back and was hoping someday to try 100mg. However, my first week on 5mg SS-31 was profound -- I could not mix it with caffeine!
I think the community protocols are a good safety net for starting, but yeah, with peptides the operative word is individual "research." -
@ogsteve This is interesting, thanks for the input. I'm waiting on more ss-31 now, I did about 18 weeks on but never went above 3.5mg daily. Maybe I've noticed less energy while not taking, but also not sure. When I start again I'll try 5-10 next go round, after about a month off. I guess I'm pretty conservative (skeered?
)with all my dosing, except for NAD - I do 100 - 150 because I can certainly tell what that's doing.@SkepticJen I have not gone that for with nad yet myself. Skeered the same. Lol
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Second day of SS-31 @ 4mg, not too much to notice. Little ichy, took some antihistamine. Took NAD+ @ 25mg. I did notice this, 24ui, red dot right away, felt stomach move with in 10minutes, and felt a kindof light headedness. This should be an interesting protocol
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SS31 going to the freezer after this vial is done. I've noticed that at this time, I do much better on days when I use NAD+, MOTS-C in AM and KPV in the evening. That's going to be my 3 for a while. Might add the rest of the TA-1 in the evening with KPV. The KPV has made a significant difference in the swelling & pain in my knee (0.750mcg).
Research on this thread has been very interesting and hope it continues. My best to everyone.
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Got a 50mg kit of SS-31 coming, I tried a mini-run with a couple of 50mg vials earlier this year topping out at 5mg a day, results were subtle but I think it did help with energy. MOTS-C was the one I couldn't feel any benefit from, NAD+ on the other hand, burns through brain fog like a torch and gives a marked increase in my ability to handle long stressful days. I'm going to bump the SS up to 10mg this time then repeat the MOTSC run and see if anything changes. I'll keep running the NAD+ continuously, love that stuff.
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@damic don’t let my comments to get to 10mg+ make you skip the titration up. That has real value and gives actionable feedback. It’s worth doing right.
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Got a 50mg kit of SS-31 coming, I tried a mini-run with a couple of 50mg vials earlier this year topping out at 5mg a day, results were subtle but I think it did help with energy. MOTS-C was the one I couldn't feel any benefit from, NAD+ on the other hand, burns through brain fog like a torch and gives a marked increase in my ability to handle long stressful days. I'm going to bump the SS up to 10mg this time then repeat the MOTSC run and see if anything changes. I'll keep running the NAD+ continuously, love that stuff.
@SwollStreetBets
I talked to my PCP yesterday who is pep friendly and she said that if even at low dose SS31 gave just a bump up, but NAD+ gave a big boost, there's probably nothing seriously wrong with the mitos, except that they're not getting enough fuel; likely because I'm a non-methylator (have MTHFR). The fact that MOTS-C is giving me a small boost on top of NAD+ means it's probably working off the methyl groups and to be careful. Another poster on here said same thing about MOTS-C using up methyl groups. I was taking a lot of methylated B vits and it was detoxing the hell out of me so might be MOTS-C could be utilizing the excess. I'm taking starting dose MOTS-C.Agree with you about NAD+! One of the greatest things since sliced bread! On my table, probably for life, along with KPV (0.750 mcg). Ahh, relief...
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@SwollStreetBets
I talked to my PCP yesterday who is pep friendly and she said that if even at low dose SS31 gave just a bump up, but NAD+ gave a big boost, there's probably nothing seriously wrong with the mitos, except that they're not getting enough fuel; likely because I'm a non-methylator (have MTHFR). The fact that MOTS-C is giving me a small boost on top of NAD+ means it's probably working off the methyl groups and to be careful. Another poster on here said same thing about MOTS-C using up methyl groups. I was taking a lot of methylated B vits and it was detoxing the hell out of me so might be MOTS-C could be utilizing the excess. I'm taking starting dose MOTS-C.Agree with you about NAD+! One of the greatest things since sliced bread! On my table, probably for life, along with KPV (0.750 mcg). Ahh, relief...
@Eleanor Take 1000mg of TMG daily and with all of the NAD and mito work, urolithin A is also a good idea along with pqq and ibiquinol.
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@Eleanor Take 1000mg of TMG daily and with all of the NAD and mito work, urolithin A is also a good idea along with pqq and ibiquinol.
@Shaqdiesel No thanks. I'm missing over 5' of bowel and not stressing it. I feel fine and have no reason to change for the time being.
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Just start SS-31 today. First does 4mg in the morning, empty stomach, not sure if that is really going to matter. Here is the plan, ensue comments:
- SS-31 - Daily 4mg for 6 weeks
- NAD+ 25mg Monday and Thursday for 2 weeks
-
- increase to 50mg for 2 weeks, then 100mg for two weeks.
6th day of SS-31, second pin of NAD+. One of the days i notice some reaction on the back shoulder, bumps, however might not be related, it was the first NAD+ day. I can tell you on the upper body day, recovery was easier. However today I was drained, and had to nap. I think I remember reading the first few weeks of SS-31 can be draining....I think this might be that. Will keep you all posted.
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6th day of SS-31, second pin of NAD+. One of the days i notice some reaction on the back shoulder, bumps, however might not be related, it was the first NAD+ day. I can tell you on the upper body day, recovery was easier. However today I was drained, and had to nap. I think I remember reading the first few weeks of SS-31 can be draining....I think this might be that. Will keep you all posted.
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6th day of SS-31, second pin of NAD+. One of the days i notice some reaction on the back shoulder, bumps, however might not be related, it was the first NAD+ day. I can tell you on the upper body day, recovery was easier. However today I was drained, and had to nap. I think I remember reading the first few weeks of SS-31 can be draining....I think this might be that. Will keep you all posted.
@damic I believe if your mitochondria are in bad shape SS-31 can initially cause some drowsiness and people can be lethargic. As they get repaired there is significant improvement. The bumps are concerning. Where did you buy your peptides from? Keep in mind everyone is different. We all react differently. What is right for one person may be wrong for another.
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@damic
That is not good -- if you think it is the NAD+, maybe try it in supplement form to help with a differential diagnosis.@mary yeah, I was a bit concerned about the bumps as they came out of no where. However I do have alergic reactions to some stuff. And have been doing a lot of things, exercise, events in life. The bumps have pretty much gone away now, so were around for 3-4 days. The second NAD+ hasn't produce a similar reaction....so unknown.
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@damic I believe if your mitochondria are in bad shape SS-31 can initially cause some drowsiness and people can be lethargic. As they get repaired there is significant improvement. The bumps are concerning. Where did you buy your peptides from? Keep in mind everyone is different. We all react differently. What is right for one person may be wrong for another.
@Stevepep Understood. NAD+ and SS-31 are both from crush. Yeah its the start of it, so will see how it progresses. I will give SS-31 a couple of weeks. Not sure the state of my my mitochondria.....anyone know of a way to tell? I saw some videos of a test, but didn't see any place were the test was actively performed.
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