Calcified tendonitis in shoulder possibly caused by peptides.
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Which AI did this?
Here is Chat's summary:What's grounded:
BPC-157 has shown pro-angiogenic (blood vessel promoting) effects in many animal and cell studies.
TB-500 (thymosin β4 fragment) is also associated with angiogenesis, cell migration, and tissue repair in preclinical research.
VEGF is indeed a major driver of new blood vessel formation.
Calcific tendinitis can enter a resorptive phase, during which macrophages and other immune cells break down calcium deposits. Ironically, this phase is often the most painful stage because of the inflammation and increased pressure.Where it becomes speculative:
That taking BPC-157 and TB-500 caused a dormant calcium deposit to enter the resorptive phase.
That they caused it by creating "massive angiogenesis."
That this sequence is a recognized "healing crisis."There are no human clinical trials demonstrating that BPC-157 or TB-500 reliably trigger rapid dissolution of calcific deposits in rotator cuff tendons through this mechanism. It's biologically plausible as a hypothesis, but it's not something that's been established in clinical evidence.
If you're going to use AI you have to use a couple, they really don't mind factchecking one another.
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5 weeks ago i stared the glow stack. 7 days on no breaks. I am sure that i have had calcium
Deposits on my rotator cuff for years. I have been doing the same upper body/shoulder workout for the past 16 months. I could never progressively overload more weight beyond what I currently am doing so I would increase reps/volume. Well 4 days ago my shoulder started to really hurt and by Friday I needed to go to the hospital out of the shear pain I was in. NOTHING compares to this pain. I had 36 hours of backlabor with no drugs and this was worse! I got an xray that showed a large calcium buildup on my rotator cuff and they gave my a steroid shot and percocet. I asked AI if the glow stack had anything to do with this event and it’s said possibly. Anyone have anything like this? I thought it would have been prevented by faking glow but boy was I wrong!@Capricorn74 your AI answer will heavily depend on what you ask it and how exactly you ask it. AI tries to align the words in the answer to the words in your question. What you may do is try to describe to AI your diet, your lifestyle, your previous diagnosis and health history to give it the full picture to choose from. Don't limit it with one peptide, there are many things happening in your life simultaneously. Macronutrients, micronutrients, food supplements, Rx medications, injuries, stresses - there are so many things that can have an effect, by itself or in combination.
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I asked AI a question this morning, it gave me an answer. I told it the answer was wrong, and it gave me a completely different answer. If you let it, it’s going to regurgitate the lowest quality and most frequently stated information, which is why posting AI info about peptides and other stuff is often extremely low value.
Even worse, the answer AI gives you might reflect perfectly what your favorite YouTuber says, which is a huge problem.
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As an example of a session, I have loaded my labs into Copilot and asked specifically what supplements and other stuff I should or should not use, what practices are good and bad, and gone back and forth with it based on the responses. I have had different sessions for hormones, peptides, cardiovascular risk, and autoimmune because they are all separate convos. With peps, you have to be really careful because there is so much bad info out there and you have to force it to give you the info you want.
FWIW, my shoulders were complete
before Wolv, Glow, and Klow and now I have 90% range of motion, few limitations on lifting, and can do things I couldn’t do for 10 years. Frayed labrum, bursitis, tendonitis, and possibly frozen shoulder syndrome. -
Upload files of data that you want AI to only consider - research papers, podcasts, whatever narrows down what you want it to consider. Tell it to only consider the data within. Word this carefully.
I have done this successfully for other topics - like design a workout plan. Of course, you have to have the background to evaluate the results. -
@Stan-Douglas which chat gpt model
That one was Sol 5.6 Extra High.
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@capricorn74
The one thing I didn't see you mention is your starting dose and how at what points in your research you increased it and the amount of increase. By no means am I an expert, but I take KLOW about every other day or every two days, which is not protocol, but I'm careful with copper (nothing to do with the other peps), and once done with present vial will not be researching it again for some time. IF your intuition leads you to feel sure that GLOW might be the problem, then please stop taking it. In this case, it might be best to trust yourself. -
5 weeks ago i stared the glow stack. 7 days on no breaks. I am sure that i have had calcium
Deposits on my rotator cuff for years. I have been doing the same upper body/shoulder workout for the past 16 months. I could never progressively overload more weight beyond what I currently am doing so I would increase reps/volume. Well 4 days ago my shoulder started to really hurt and by Friday I needed to go to the hospital out of the shear pain I was in. NOTHING compares to this pain. I had 36 hours of backlabor with no drugs and this was worse! I got an xray that showed a large calcium buildup on my rotator cuff and they gave my a steroid shot and percocet. I asked AI if the glow stack had anything to do with this event and it’s said possibly. Anyone have anything like this? I thought it would have been prevented by faking glow but boy was I wrong!Angiogenesis is the biological process by which new blood vessels form from pre-existing ones to support growth, wound healing, and tumor expansion. It is triggered by pathogens, physical trauma, or toxic chemicals.
Inflammation on the other hand is a protective chemical and cellular process triggered by cell injury or infection, driven primarily by key mediators like histamine, prostaglandins, and cytokines. Angtiogenesis doesn't cause inflammation. In a case like yours, a chronic existing injury & damage had already triggered an inflammatory state as your body attempted to repair the damage. You said you had had issues for 16 years, so as in many cases, the repair process was ineffective but ongoing. As these calcium deposits continue to accumulate and grow bigger, they become irritated and can cause severe pain. Your body attempts to repair the damage in several ways including sending macrophages to breakdown the hardened crystals. It also triggers an inflammatory response to create a protective cushion around the injury in an attempt to limit movement and stop further injury. As it heals from calcification, it can be painful as the tissues reabsorb the calcium. When the body is not able to heal quickly due to aging or continued injury to the area then the constant inflammation can actually cause even more damage to surrounding blood vessels and tissue creating an ongoing vicious cycle.
TB500 and BPC157 are similar to the body's own peptides that are used in this process. They focus on signaling progenitor and repair cells & promote nutrient and oxygen delivery to the injury by angiogenesis which is the formation of new blood vessels. While they also help to regulate and decrease inflammation, the process of forming new blood vessels will increase blood flow to the area which will cause pain.
Had your body been able to repair itself without supplementing with peptides, it would have gone through the same painful steps.Basically, to sum it up, the peptides did not cause your increased pain, they just jumpstarted and sped up a stalled healing process in which pain is already a byproduct.
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The glow stack likely didn't cause this but there is no way to know for sure. You are a researcher after all.
Ai is going to default to the safest answer due to its guardrails and the model. It's responsible for a lot of bad information and even worse influencers.
Calcific tendinitis is something older people in my circle have dealt with. One inevitably had it cleaned out and hasn't looked back.
@Randy I just used Google AI. I have an appointment on the 25th of this month to hopefully get both shoulders cleaned out. Barbotage procedure. For now I have stopped all peptides. Except Reta. I can’t really workout right now and I am not gaining my weight back! Oh and yeah, I am on the older side. 52. It’s a weird space to be in. I’m not old but not young and trying to accept the aging process and its effects. I was taking the glow stack to fix my left shoulder and ended up with shoulder pain on my right. I guess this is what I get.
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The glow stack likely didn't cause this but there is no way to know for sure. You are a researcher after all.
Ai is going to default to the safest answer due to its guardrails and the model. It's responsible for a lot of bad information and even worse influencers.
Calcific tendinitis is something older people in my circle have dealt with. One inevitably had it cleaned out and hasn't looked back.
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