Dysesthesia, less or worse from different vendors for Reta?
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I’ve had it from the beginning. Center lower neck / upper back, and back of arms. Vendor of Nexaph, aavant, and two china vials, did not change it. Compression wear so there’s no rubbing is my answer.
@MyB yes, compression worked for me. Antihistamines did not. But it’s still a side effect I wouldn’t put up with if not for appreciating the underlying mechanism. I don’t know if the general population will tolerate it if Lilly brings it to market like this. 5-20% risk of this side effect is nuts. And I have a rise in resting heart rate of about 10 beats, and I don’t think that’s a side effect most can avoid due to the glucagon agonist. I think our population is more forgiving of these things than when doctors start pushing it in the same breath as statins. I think people would have loved statins as a class if they had no side effects that impacted quality of life.
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Dysesthesia is not the vendors. It is in the dose. Thats why it is suggested to start low and titrate up slowly. Allow the body to adjust.
"Glucagon Receptor Activation: Glucagon receptors are present on peripheral nerve endings. Data from clinical trials suggests that when retatrutide binds to these receptors—particularly at higher doses—it can trigger abnormal, spontaneous firing in the sensory nerves right below the skin. This is why retatrutide has a significantly higher rate of dysesthesia (up to 21% at maximum doses) compared to single-hormone alternatives."2M
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Dysesthesia is not the vendors. It is in the dose. Thats why it is suggested to start low and titrate up slowly. Allow the body to adjust.
"Glucagon Receptor Activation: Glucagon receptors are present on peripheral nerve endings. Data from clinical trials suggests that when retatrutide binds to these receptors—particularly at higher doses—it can trigger abnormal, spontaneous firing in the sensory nerves right below the skin. This is why retatrutide has a significantly higher rate of dysesthesia (up to 21% at maximum doses) compared to single-hormone alternatives."@EXTROPIAN I have to disagree, my research with my own experience. Same dose various vendors and I've experienced this only with half of them. So I have to assume it's the supply not the dose.
Just someone with a fridge full of research and a browser history that would concern my doctor.
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@EXTROPIAN I have to disagree, my research with my own experience. Same dose various vendors and I've experienced this only with half of them. So I have to assume it's the supply not the dose.
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@EXTROPIAN I have to disagree, my research with my own experience. Same dose various vendors and I've experienced this only with half of them. So I have to assume it's the supply not the dose.
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I've only used Reta from two different U.S. resell vendors; Compound Sciences and Crush. Both are effective and I did experience sunburn sensation including what I would describe the beginning symptoms of Shingles, (intermittent stinging nerve pain similar to fire ant stings.) None of these symptoms lasted very long, and after I got above the 2.5mg weekly dose, it hasn't returned. I will say I've experienced Shingles like nerve pain intermittently just out of the blue a few times a year ever since I had Shingles ten years ago, so maybe I'm just sensitive to products that are known for these side effects.
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@BeeKind what was the lowest dose you has dysesthesia? I experiences it on my first 3mg.
3mg. Now is my last 2mg Reta. A week ago I added Tesa 1mg and entire body has dysesthesia. Rating 1 to 10 its a 4 in intensity but I do feel it. I stopped and its going away. I am about to exit Reta so I shelved tesa. I really dont need it. I was just curious. As for tesa, just fast over night and you'll lose weight for sure. Not as fast but you will. Just stop eating the 'slop.
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3mg. Now is my last 2mg Reta. A week ago I added Tesa 1mg and entire body has dysesthesia. Rating 1 to 10 its a 4 in intensity but I do feel it. I stopped and its going away. I am about to exit Reta so I shelved tesa. I really dont need it. I was just curious. As for tesa, just fast over night and you'll lose weight for sure. Not as fast but you will. Just stop eating the 'slop.
@EXTROPIAN I had to stop reta. My last pin was last Thursday. The skin sensation was not going away. I held out for a month, and it became so bothersome I couldn’t sleep. I don’t know if I will try again with another vendor as some here suggested or just do Randy’s ghetto reta with tirz and maz/sourvo.
It’s been a week, and it’s still there, though. I’m kinda afraid the skin thing won’t ever go away. In the papers, it says ‘most’ people with the symptom see it resolve after discontinuation. I’m not being a baby about it. In fact, I probably let it go on too long just because I wanted very badly to like reta. Just walking is uncomfortable with the fabric moving against my legs. Sigh. -
@EXTROPIAN I had to stop reta. My last pin was last Thursday. The skin sensation was not going away. I held out for a month, and it became so bothersome I couldn’t sleep. I don’t know if I will try again with another vendor as some here suggested or just do Randy’s ghetto reta with tirz and maz/sourvo.
It’s been a week, and it’s still there, though. I’m kinda afraid the skin thing won’t ever go away. In the papers, it says ‘most’ people with the symptom see it resolve after discontinuation. I’m not being a baby about it. In fact, I probably let it go on too long just because I wanted very badly to like reta. Just walking is uncomfortable with the fabric moving against my legs. Sigh.@jennn I assure you it will go away but did wonder what if. It take a few weeks but it does go away. I resently stopped tesa because i got it again and it is going away. And I thought it was a glucagon thing. It was more prominent on my abdoment and legs where I pin. Maybe it was the body telling me something. "Pss we are here already" I am happy with the results.
When I got it with Reta at 3mg. Yes it was so uncomfortable. And yes I was wondering if it was.going away. I did try 3mg again and it didn't happen but personally it felt like the 2mg. I am curious why tesa gave me dys' if it wasn't the glucagon. I did read somewhere that tesa does as well. Answer was fluid compression against nerves. -
I've been on reta for almost a year. I get this sensation on my scalp, sometimes part of my face and my forearms and hands. Intensity varies but it has never been super bad. However, now at 5mg and it still hasn't vanished.
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I've been on reta for almost a year. I get this sensation on my scalp, sometimes part of my face and my forearms and hands. Intensity varies but it has never been super bad. However, now at 5mg and it still hasn't vanished.
@Shaqdiesel I get it in my scalp and my left thigh. Its been at least a month since I last felt it. Idk if it was just me but certain suppliers had that effect and others didnt. But in the end it all comes from one-ish place right?
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I experienced this with the ghetto stack tirz /maz, tirz 5mg Sunday & maz 6mg Wednesday, I had been running tirz 5mg for several months (diabetics maintaince dose)
titrated up on the maz from 2mg to 6 mg over 2 months the 6mg dose kicked it off, two days later I stopped both doses this week and it has got better almost completely gone. I think Ill titrate back up and stop at 4mg because it was helping.
when it was at its worse I dreaded riding to work the railroad tracks where my worst enemy if you know you know. -
I experienced this with the ghetto stack tirz /maz, tirz 5mg Sunday & maz 6mg Wednesday, I had been running tirz 5mg for several months (diabetics maintaince dose)
titrated up on the maz from 2mg to 6 mg over 2 months the 6mg dose kicked it off, two days later I stopped both doses this week and it has got better almost completely gone. I think Ill titrate back up and stop at 4mg because it was helping.
when it was at its worse I dreaded riding to work the railroad tracks where my worst enemy if you know you know.@JustinWalker2002 yeah I guess anything that hits the glucagon receptor hard will have the potential to trigger this. I’m not looking forward to it happening again with ghetto reta or just a different vendor. Whatever I try next, I’ll go waaay slower. I did more of the higher dose that was in the studies instead of starting with 0.5.
My resting heart rate average also jumped 10 point per my watch data. That hasn’t gotten any better off reta yet either. More glucagon receptor activation issues. -
I have it bad. Back of scalp, under arms and thighs - just like a lot of people here mentioned. From what I've read, and has already been stated here, it's the receptors firing off and, to be honest...and I'm weird, but I am kinda partial to it. It lets me know that the shitty grey market/dark alley RETA I've been getting is actually RETA. The RHR and all the other listed side effects are definitely along for the ride as well. Lilly will definitely have to fight this one if they bring it to market for most people, though. This is through 4 different vendors and titrating up from 1 mg to 5 mg where I am at now. It started pretty heavy at around 2.5 mg. All in the name of research!
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I have it on my eyelids,
So, is it a good thing? Like, is it waking up or healing my nerves or anything?
i would like to think it is good. -
I have it bad. Back of scalp, under arms and thighs - just like a lot of people here mentioned. From what I've read, and has already been stated here, it's the receptors firing off and, to be honest...and I'm weird, but I am kinda partial to it. It lets me know that the shitty grey market/dark alley RETA I've been getting is actually RETA. The RHR and all the other listed side effects are definitely along for the ride as well. Lilly will definitely have to fight this one if they bring it to market for most people, though. This is through 4 different vendors and titrating up from 1 mg to 5 mg where I am at now. It started pretty heavy at around 2.5 mg. All in the name of research!
@dustingrieser Lol I was the same way at first! I was like, I damn well know I got the right stuff. But after a month, I can’t take it. It’s not any better, maybe worse. It’s been 8 days off and only minimally better. Lilly will have to do something about this. This is not a side effect that normal people will put up with. I’m willing to try another source, but you said it happened with 4 different sources you tried? But it got better despite pushing up the dose??
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