Have a 120lb female that would like some advice on dossing? She is currently researching KLOW 2.5mg daily and Reta 0.5 each week. Considering 1mg each day of SS-31. What time of day?

Hey @Randy, you want to know how to get all the girls to swoon over ya?
By doing a giveaway like this one!

What is the suggested protocol. Just got confused by other posts. @randy you love it please chime in. I am titrating starting at 1mg up to 5 for the last 5 days for 20 days total. Just started

My lab rat over worked his little legs on his wheel, so I got him a little something to help him with his leg muscle and tendon.
Genpeptide has good prices, fast shipping and secure discrete packaging.

I noticed the majority of posts on this site with regard to Pinealon research because of sleep issues. I'm wanting neuro benefits of memory, clarity, etc.

Is there anyone here who's gotten benefits other than better sleep?

I also see most info favors researching it in morning hours. I don't want kitty to fall asleep at work...

I previously bought Dihexa from Limitless bio chem, but tbh i'm not feeling any difference after 3 weeks of using it. I have heard people saying they saw difference as week 1, so I'm curious which would be a trustworthy vendor to buy from for the best quality.

This is at least the 2nd time this has happened with a vendor. I will not send any of them my DL info. Sent them a refusal note on the grounds that I already had an account with them and they sent the order through. (Other than that, I like their products.)

I hope this doesn't become a habit with vendors.

On another thread here was a discussion of TB4 and BPC157, 1 to 1 ratio in premixed formulas not being accurate with regard to the individual dosages of the two. I agree with this assessment and since I cannot afford to dose kitty individually, I'm going to try Cartalax first and see if it resolves any of the joint and other tissue pain she has. As we all know, the cost of peptides can be prohibitive, at least for us.

Any comments/information is welcomed. Wish cat the best. She's old and hurting.

This is a vendor review submitted by StevenKing on PeptideCritic.com.

Rating: (1/5)

Review

I completely agree with Chad here, something is definitely off with this vendor. I’m into my fourth week on their batch, and honestly, it’s been a total letdown. Not only am I getting zero noticeable results from my usual dose, but I’ve also suddenly come down with a brutal headache and stomach pain. There’s a chance I just caught a bug from someone who was sick around me, but the timing is just too sketchy to ignore. When you get none of the actual benefits but all of these random, miserable side effects, it really makes you question the purity of what they're shipping out. Just like Chad said, the difference between a solid vendor and this one is night and day. On another note, my MOT-C effects seems fine.

Shop Glacier Aminos

Read the full review: Something Off

Discuss this review, share your own experiences, or ask questions about the vendor.

Please keep discussions respectful and factual.

For research use only. Not medical advice.

The goal:

Tirzepatide = GLP-1 + GIP
Survodutide or Mazdutide = GLP-1 + Glucagon
→ Combined effect = GLP-1 + GIP + Glucagon, i.e., a retatrutide-like profile.

Because both second agents have a glucagon hit, titration must be slower than usual to avoid nausea, low appetite floor, or excessive gastric slowing.

Why do this?

1. You stockpiled too much tirz.
2. Break a stall.
3. Reta itch/allodynia or other intolerable side effects when researching reta.

1. Tirzepatide + Survodutide

Survodutide has a stronger glucagon hit than mazdutide. This is the more potent combination.

Weekly Titration Schedule

Weeks 1–4

Tirzepatide: 2.5 mg weekly

Survodutide: 0.3 mg weekly
Purpose: Establish baseline tolerability. Survo kicks hard early.

Weeks 5–8

Tirzepatide: 5 mg weekly

Survodutide: 0.6 mg weekly
Notes: Appetite suppression becomes extremely strong for many subjects here.

Weeks 9–12

Tirzepatide: 7.5 mg weekly

Survodutide: 1.0 mg weekly

This is the sweet spot for most research models. Strong “reta-like” effect emerges.

Week 13+ Maintenance

Two viable approaches:

Standard Maintenance

Tirzepatide: 7.5–10 mg

Survodutide: 1.0–1.5 mg

High-End (Aggressive) Maintenance

Tirzepatide: 10–12.5 mg

Survodutide: 1.5–2.0 mg

Only for researchers replicating the high-end metabolic punch of retatrutide.

Notes

Survodutide plus tirz amplifies appetite suppression so hard that most people do not need high tirz dosing.

Escalate slowly — both compounds slow gastric emptying.

This combo is more GC-heavy than mazdutide, so itch issues are less common compared to retatrutide, but GI load is higher.

2. Tirzepatide + Mazdutide (Ghetto Reta v2 — Milder, Cleaner)

Mazdutide has a slightly softer glucagon hit and a less aggressive appetite cliff.
This stack is smoother and usually more tolerable.

Tirzepatide + Mazdutide

Weeks 1–4

Tirzepatide: 2.5 mg weekly

Mazdutide: 2 mg weekly

Weeks 5–8

Tirzepatide: 5 mg weekly

Mazdutide: 4 mg weekly

Weeks 9–12

Tirzepatide: 7.5 mg weekly

Mazdutide: 6 mg weekly

This combo mimics a “mid-dose retatrutide” effect without the itch or violent GI spike.

Week 13+ Maintenance

Tirzepatide: 7.5–10 mg

Mazdutide: 6–8 mg

High-End (Not common)

Tirzepatide: 10–12.5 mg

Mazdutide: 8–10 mg

Notes

Mazdutide is smoother but still synergistic with tirz.

Appetite suppression is strong but less harsh than survo stacks.

GI load increases if escalated too fast — keep 4-week steps.

My rat name Extropy has been researching for 5mo with great results. From metabolic reset, mitochondria optimizing, mental health, longevity, immune and yes she went all in. She is filtering all the peps into pen cartridges as suggested here. In one sitting Extropy has been able to push a set of 2-4 cartridges through one 33Gx4mm pin tip. After she finish the pen tip it gets discarted. She hasn't had any issues. Anyone doing the same or?

This is a vendor review submitted by WesEqualshXc on PeptideCritic.com.

Rating: (5/5)

Review

Have you ever developed a crush on somebody and couldn't help but want to text them? Yeah, that happened to me with this company. After I received my first order, which shipped pretty quickly, I found myself going back to their website several times debating whether or not I should spend the money to buy more stuff. For my money, they strike a perfect balance between price, packaging, convenience, and detailed COAs. I’ll probably continue to buy from these guys.

Shop Crush Research

Read the full review: I’m developing a massive Crush!

Discuss this review, share your own experiences, or ask questions about the vendor.

Please keep discussions respectful and factual.

Aavant just announced another restock. They are usa based, lio in the states (allegedly), ships from ohio and sells out quick. These prices are lower than grey (unless buying 100 kits).

Join here https://t.me/+zyQ_V2wK4vY1NDg5

Test groups always form and its a wonderful community.

These sell out FAST.

My rat Extropy has been using V2 pens for 3mo now and I'm about to upgrade. When she pinch, pin and pray. Extropy lets it sit in her for 10-20 seconds before pulling out slowly. She still notices a drop of peps on the pin tip. She is now using 33G x 4mm, but also it did the same with a 32G. There is a few MCGs lost in every pin. Lately she has been unscrewing the pen reservoir to not lose any more peps. Yes she did use to remove the pen tip but by the time you cap it and unscrew the mcgs add up. It a decent little drop. I didn't mind it, considering it is clear there isn't a backwash into the cartridge. Time to upgrade, "this is the way"...? Follistatin-344 and tesa are not cheap. Please advise.

Well I just had an unpleasant experience. I just wasted a half a vial of NAD+. Upon filling some pen cartridges I had the bottom plug pop out the bottom of not one, but two cartridges (spilling all of the energy juice into oblivion). I was using a 31 gauge breather needle and a 31 gauge needle on the end of the .2-13mm filter. I've done it this way before with no issues. I didn't think I was pushing too hard or fast on the plunger but I guess I could have. I changed the breather needle on the next two cartridges and everything went as planned. Could it have been a bad breather needle? 31 gauge needles are too small (for breather or filter)? Or was I simply pushing too fast and didn't realize it?

What's your theory as to what the problem may have been. I lost half of my 10mL vial due to this mistake, so I darn sure want to learn from it.

I hate to be an enabler for all the FOMO and hoarder peeps out there, but I thought it might be a good idea to have a centralized location for all of the July 4th sales. This wouldn't necessarily be an endorsement for any particular vendor or a review, but rather an FYI for what's out there.

Genpeptide - 25% off peptides. An additional 10% discount of purchases over $1000. Valid June 26th to July 6th.
-EDIT- FREEDOM25 is the discount code.

Received via email marketing. Out of curiosity, I tested the code and it appears (as of this writing) that it will not apply to their "Build a Kit". Only one coupon code is allowed so it isn't stackable with the Peptide Critic 10% off code.

One of the vendors I use mainly have test results from AFI. I cannot find any information about them anywhere on the internet. I have seen reddit posts stating they are fake. I have seen your review saying they are not, but it somehow still seems sketchy. Others have stated their methods for testing are not exactly up to Janoshik standards. At this point I don’t mnow what to believe and am just looking for a more believable reason to trust them. I have inventory that I have not touched because of this. Any help is appreciated. Thanks in advance

Tucson-based company with a solid selection of research nootropics and powders. I find their peptides generally overpriced, but their bulk powders appear to be better value from my estimation. I’ve ordered from them several times without any issues and was generally happy with the product quality. I can verify their MT2 definitely gave my rat a dark tan.
Unfortunately, my most recent order went wrong. I placed a ~$195 order that included four items, but they only shipped three, the $85 bottle of enclomiphene was missing. I emailed them twice regarding the missing item and never received a response. It’s disappointing that a relatively straightforward issue like this wasn’t addressed.
I had a good experience with them previously, but this situation has made me hesitant to order again.

UPDATE: After a couple more email attemps, they did make it right & sent me the missing package! Great vendor.

I've heard of very few who have not regained their weight, sometimes more, once they stop Semi/Tirz/Reta. There are some that claim to not have regained the weight, or a large portion of it but no proof to back it up that I know of. It's possible; I just don't know any of them.

Most of us here at least have the notion that we're probably going to be taking weight loss peptides for the rest of our lives, with the only other choice being micro-dosing, instead of higher doses.

The 'therapeutic dose' of Tirz is 5mg, therefore, IMO, anything under that is micro-dosing. I know lots of experts are saying 2.5 or less are the levels, but that doesn't make sense to me. Whatever.

I'm at 6 Tirz/1 Survo right now and after a month-long stall after dropping 30#'s, my weight is starting to drop again due to the Survo, albeit slowly. Think it's going to be this way for the next 20 lbs that I need to lose, unless I really exercise hard (Not likely)

Anyone else considering micro-dose? Doesn't mean you have to give up the other peps, just the ones for weight loss.

Note: If you want Tirz (Zepbound) from ELilly, you get quick pens, no other options. I'm spoiled now since joining this forum and want to determine my own doses but there are GREAT options now for those who want and need them.

https://youtu.be/A-huqMRkvk4?si=L9erpJraVYs_7ypO