For research use only. Not medical advice.
The goal:
Tirzepatide = GLP-1 + GIP
Survodutide or Mazdutide = GLP-1 + Glucagon
→ Combined effect = GLP-1 + GIP + Glucagon, i.e., a retatrutide-like profile.
Because both second agents have a glucagon hit, titration must be slower than usual to avoid nausea, low appetite floor, or excessive gastric slowing.
Why do this?
- You stockpiled too much tirz.
- Break a stall.
- Reta itch/allodynia or other intolerable side effects when researching reta.
1. Tirzepatide + Survodutide
Survodutide has a stronger glucagon hit than mazdutide. This is the more potent combination.
Weekly Titration Schedule
Weeks 1–4
Tirzepatide: 2.5 mg weekly
Survodutide: 0.3 mg weekly
Purpose: Establish baseline tolerability. Survo kicks hard early.
Weeks 5–8
Tirzepatide: 5 mg weekly
Survodutide: 0.6 mg weekly
Notes: Appetite suppression becomes extremely strong for many subjects here.
Weeks 9–12
Tirzepatide: 7.5 mg weekly
Survodutide: 1.0 mg weekly
This is the sweet spot for most research models. Strong “reta-like” effect emerges.
Week 13+ Maintenance
Two viable approaches:
Standard Maintenance
Tirzepatide: 7.5–10 mg
Survodutide: 1.0–1.5 mg
High-End (Aggressive) Maintenance
Tirzepatide: 10–12.5 mg
Survodutide: 1.5–2.0 mg
Only for researchers replicating the high-end metabolic punch of retatrutide.
Notes
Survodutide plus tirz amplifies appetite suppression so hard that most people do not need high tirz dosing.
Escalate slowly — both compounds slow gastric emptying.
This combo is more GC-heavy than mazdutide, so itch issues are less common compared to retatrutide, but GI load is higher.
- Tirzepatide + Mazdutide (Ghetto Reta v2 — Milder, Cleaner)
Mazdutide has a slightly softer glucagon hit and a less aggressive appetite cliff.
This stack is smoother and usually more tolerable.
Tirzepatide + Mazdutide
Weeks 1–4
Tirzepatide: 2.5 mg weekly
Mazdutide: 2 mg weekly
Weeks 5–8
Tirzepatide: 5 mg weekly
Mazdutide: 4 mg weekly
Weeks 9–12
Tirzepatide: 7.5 mg weekly
Mazdutide: 6 mg weekly
This combo mimics a “mid-dose retatrutide” effect without the itch or violent GI spike.
Week 13+ Maintenance
Tirzepatide: 7.5–10 mg
Mazdutide: 6–8 mg
High-End (Not common)
Tirzepatide: 10–12.5 mg
Mazdutide: 8–10 mg
Notes
Mazdutide is smoother but still synergistic with tirz.
Appetite suppression is strong but less harsh than survo stacks.
GI load increases if escalated too fast — keep 4-week steps.