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  3. Dysesthesia, less or worse from different vendors for Reta?
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Dysesthesia, less or worse from different vendors for Reta?

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  • J jennn

    @EXTROPIAN I had to stop reta. My last pin was last Thursday. The skin sensation was not going away. I held out for a month, and it became so bothersome I couldn’t sleep. I don’t know if I will try again with another vendor as some here suggested or just do Randy’s ghetto reta with tirz and maz/sourvo.
    It’s been a week, and it’s still there, though. I’m kinda afraid the skin thing won’t ever go away. In the papers, it says ‘most’ people with the symptom see it resolve after discontinuation. I’m not being a baby about it. In fact, I probably let it go on too long just because I wanted very badly to like reta. Just walking is uncomfortable with the fabric moving against my legs. Sigh.

    EXTROPIANE Offline
    EXTROPIANE Offline
    EXTROPIAN
    wrote last edited by EXTROPIAN
    #19

    @jennn I assure you it will go away but did wonder what if. It take a few weeks but it does go away. I resently stopped tesa because i got it again and it is going away. And I thought it was a glucagon thing. It was more prominent on my abdoment and legs where I pin. Maybe it was the body telling me something. "Pss we are here already" I am happy with the results.
    When I got it with Reta at 3mg. Yes it was so uncomfortable. And yes I was wondering if it was.going away. I did try 3mg again and it didn't happen but personally it felt like the 2mg. I am curious why tesa gave me dys' if it wasn't the glucagon. I did read somewhere that tesa does as well. Answer was fluid compression against nerves.

    2M

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    • S Offline
      S Offline
      Shaqdiesel
      wrote last edited by
      #20

      I've been on reta for almost a year. I get this sensation on my scalp, sometimes part of my face and my forearms and hands. Intensity varies but it has never been super bad. However, now at 5mg and it still hasn't vanished.

      BeeKindB 1 Reply Last reply
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      • S Shaqdiesel

        I've been on reta for almost a year. I get this sensation on my scalp, sometimes part of my face and my forearms and hands. Intensity varies but it has never been super bad. However, now at 5mg and it still hasn't vanished.

        BeeKindB Offline
        BeeKindB Offline
        BeeKind
        wrote last edited by
        #21

        @Shaqdiesel I get it in my scalp and my left thigh. Its been at least a month since I last felt it. Idk if it was just me but certain suppliers had that effect and others didnt. But in the end it all comes from one-ish place right?

        Just someone with a fridge full of research and a browser history that would concern my doctor.

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        • J Offline
          J Offline
          JustinWalker2002
          wrote last edited by
          #22

          I experienced this with the ghetto stack tirz /maz, tirz 5mg Sunday & maz 6mg Wednesday, I had been running tirz 5mg for several months (diabetics maintaince dose)
          titrated up on the maz from 2mg to 6 mg over 2 months the 6mg dose kicked it off, two days later I stopped both doses this week and it has got better almost completely gone. I think Ill titrate back up and stop at 4mg because it was helping.
          when it was at its worse I dreaded riding to work the railroad tracks where my worst enemy if you know you know.

          J 1 Reply Last reply
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          • J JustinWalker2002

            I experienced this with the ghetto stack tirz /maz, tirz 5mg Sunday & maz 6mg Wednesday, I had been running tirz 5mg for several months (diabetics maintaince dose)
            titrated up on the maz from 2mg to 6 mg over 2 months the 6mg dose kicked it off, two days later I stopped both doses this week and it has got better almost completely gone. I think Ill titrate back up and stop at 4mg because it was helping.
            when it was at its worse I dreaded riding to work the railroad tracks where my worst enemy if you know you know.

            J Offline
            J Offline
            jennn
            wrote last edited by
            #23

            @JustinWalker2002 yeah I guess anything that hits the glucagon receptor hard will have the potential to trigger this. I’m not looking forward to it happening again with ghetto reta or just a different vendor. Whatever I try next, I’ll go waaay slower. I did more of the higher dose that was in the studies instead of starting with 0.5.
            My resting heart rate average also jumped 10 point per my watch data. That hasn’t gotten any better off reta yet either. More glucagon receptor activation issues.

            1 Reply Last reply
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            • D Offline
              D Offline
              dustingrieser
              wrote last edited by
              #24

              I have it bad. Back of scalp, under arms and thighs - just like a lot of people here mentioned. From what I've read, and has already been stated here, it's the receptors firing off and, to be honest...and I'm weird, but I am kinda partial to it. It lets me know that the shitty grey market/dark alley RETA I've been getting is actually RETA. The RHR and all the other listed side effects are definitely along for the ride as well. Lilly will definitely have to fight this one if they bring it to market for most people, though. This is through 4 different vendors and titrating up from 1 mg to 5 mg where I am at now. It started pretty heavy at around 2.5 mg. All in the name of research!

              J 1 Reply Last reply
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              • M Offline
                M Offline
                mussels4muscles
                wrote last edited by
                #25

                I have it on my eyelids,
                So, is it a good thing? Like, is it waking up or healing my nerves or anything?
                i would like to think it is good.

                J 1 Reply Last reply
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                • D dustingrieser

                  I have it bad. Back of scalp, under arms and thighs - just like a lot of people here mentioned. From what I've read, and has already been stated here, it's the receptors firing off and, to be honest...and I'm weird, but I am kinda partial to it. It lets me know that the shitty grey market/dark alley RETA I've been getting is actually RETA. The RHR and all the other listed side effects are definitely along for the ride as well. Lilly will definitely have to fight this one if they bring it to market for most people, though. This is through 4 different vendors and titrating up from 1 mg to 5 mg where I am at now. It started pretty heavy at around 2.5 mg. All in the name of research!

                  J Offline
                  J Offline
                  jennn
                  wrote last edited by
                  #26

                  @dustingrieser Lol I was the same way at first! I was like, I damn well know I got the right stuff. But after a month, I can’t take it. It’s not any better, maybe worse. It’s been 8 days off and only minimally better. Lilly will have to do something about this. This is not a side effect that normal people will put up with. I’m willing to try another source, but you said it happened with 4 different sources you tried? But it got better despite pushing up the dose??

                  D 1 Reply Last reply
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                  • M mussels4muscles

                    I have it on my eyelids,
                    So, is it a good thing? Like, is it waking up or healing my nerves or anything?
                    i would like to think it is good.

                    J Offline
                    J Offline
                    jennn
                    wrote last edited by
                    #27

                    @ed1 I heard eyelids are actually a common site for this to happen. And it’s not good or bad… it’s just that you know you have real reta if it’s happening. Not a vial of nondescript white powder you’re shooting up. Lol
                    But I feel like the tops of my thighs have to have blisters. I can’t believe there is no physical sign on me. It feels like a real burn, not a sunburn anymore. I had to stop it.

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                    • J jennn

                      @dustingrieser Lol I was the same way at first! I was like, I damn well know I got the right stuff. But after a month, I can’t take it. It’s not any better, maybe worse. It’s been 8 days off and only minimally better. Lilly will have to do something about this. This is not a side effect that normal people will put up with. I’m willing to try another source, but you said it happened with 4 different sources you tried? But it got better despite pushing up the dose??

                      D Offline
                      D Offline
                      dustingrieser
                      wrote last edited by dustingrieser
                      #28

                      @jennn said:

                      @dustingrieser Lol I was the same way at first! I was like, I damn well know I got the right stuff. But after a month, I can’t take it. It’s not any better, maybe worse. It’s been 8 days off and only minimally better. Lilly will have to do something about this. This is not a side effect that normal people will put up with. I’m willing to try another source, but you said it happened with 4 different sources you tried? But it got better despite pushing up the dose??

                      I wouldn't say it got worse with the higher dosage but it certainly didn't get better. The level of burn stayed about the same after 2.5 on up. Feel the burn. Edit -yes, the source did not matter. It's just a straight up effect of RETA and there's no way most people are going to put up with it if the numbers are true at 20% at higher doses.

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                      • T taryn

                        Did any of you have this? Did you notice it with certain vendors over other ones? If yours went away how long did it take?

                        If it's vendor related, what do you think could be causing it? I really like that Crush has heavy metal screening. It's concerning that there is any in the products at all but there are heavy metals in our foods and environmental too. Do we trust ILS with those scores.

                        Would a filter clean these out too? Seem worth a try?

                        bfullerB Offline
                        bfullerB Offline
                        bfuller
                        wrote last edited by
                        #29

                        @Trex I don't think you can claim it is caused by heavy metals becasue it is a side effect witnessed in the Triumph trials by Eli Lilly, and rest assured they have a clean source of Reta for thir clinical trials.

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                        • EXTROPIANE Offline
                          EXTROPIANE Offline
                          EXTROPIAN
                          wrote last edited by
                          #30

                          Its mainly caused by the glucogon and the glp1 at high dosages.

                          2M

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                          • EXTROPIANE Offline
                            EXTROPIANE Offline
                            EXTROPIAN
                            wrote last edited by
                            #31

                            https://youtu.be/nYUMLbjE2wA?is=LK7UMlipPZXToeFz

                            2M

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