Dysesthesia, less or worse from different vendors for Reta?
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Did any of you have this? Did you notice it with certain vendors over other ones? If yours went away how long did it take?
If it's vendor related, what do you think could be causing it? I really like that Crush has heavy metal screening. It's concerning that there is any in the products at all but there are heavy metals in our foods and environmental too. Do we trust ILS with those scores.
Would a filter clean these out too? Seem worth a try?
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Did any of you have this? Did you notice it with certain vendors over other ones? If yours went away how long did it take?
If it's vendor related, what do you think could be causing it? I really like that Crush has heavy metal screening. It's concerning that there is any in the products at all but there are heavy metals in our foods and environmental too. Do we trust ILS with those scores.
Would a filter clean these out too? Seem worth a try?
@Trex I have it fairly bad. It feels like a sunburn on the top of my thighs and the sides of my arms. Clothing or a blanket will bother me. So far I live with it because they say it goes away between one and two months. I have only been on it for about one month, so I’m hoping it will start to fade. I’ve only read one plausible explanation for why this happens and it is in this YouTube video. This guy who is supposedly an MD says it’s because there are glucagon receptors in nerve cells, and that this skin thing is actually a sign that your glucagon receptors are getting activated. I’ve never heard of that, but I haven’t heard of a lot of things. Regardless, I’ve read the data, and at 4 mg, 8% of people have it. But at higher doses, up to 20% of people have it. If it feels like it does with me, this is not going to be a side effect many people would put up with. Lilly is going to have to do something about that.
Anyway, this YouTube video is pretty interesting. He found a tidbit of data somewhere that seems to imply that the glucagon receptor doesn’t get activated until you get to higher doses like 4 mg. If that’s true, that is a pretty significant piece of information for those people that microdose this.https://youtu.be/oUL18iO18Oc?is=kZofD9_WawjoiSm4
The stuff I talked about above is at the two minute mark.
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I'm sorry you have it too. I'm still only at 2mg and have worked my way up very slowly over several months. I used to have neuropathy but it randomly went away but this feels kinda similar. Like I wore something too tight and all my hairs are laying in the wrong direction when I touch my skin. Or like my fine hairs are little thin cactus tines.
I'm finally losing weight and I'm not able to be really active right now so I'm trying to be grateful and increase my movement and circulation as much as possible.
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Ive definitely experienced it worse from certain vendors. One vendor it was my thigh for weeks. Another vendor it was my scalp. Current vendor I dont have that effect.
Personally crush is on my shitlist because they switched to ILS then switched back and when I purchased I ended up with vials from 3 COAs back which was ILS tested. I do not trust ILS -
I’ve had it from the beginning. Center lower neck / upper back, and back of arms. Vendor of Nexaph, aavant, and two china vials, did not change it. Compression wear so there’s no rubbing is my answer.
@MyB yes, compression worked for me. Antihistamines did not. But it’s still a side effect I wouldn’t put up with if not for appreciating the underlying mechanism. I don’t know if the general population will tolerate it if Lilly brings it to market like this. 5-20% risk of this side effect is nuts. And I have a rise in resting heart rate of about 10 beats, and I don’t think that’s a side effect most can avoid due to the glucagon agonist. I think our population is more forgiving of these things than when doctors start pushing it in the same breath as statins. I think people would have loved statins as a class if they had no side effects that impacted quality of life.
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Dysesthesia is not the vendors. It is in the dose. Thats why it is suggested to start low and titrate up slowly. Allow the body to adjust.
"Glucagon Receptor Activation: Glucagon receptors are present on peripheral nerve endings. Data from clinical trials suggests that when retatrutide binds to these receptors—particularly at higher doses—it can trigger abnormal, spontaneous firing in the sensory nerves right below the skin. This is why retatrutide has a significantly higher rate of dysesthesia (up to 21% at maximum doses) compared to single-hormone alternatives." -
Dysesthesia is not the vendors. It is in the dose. Thats why it is suggested to start low and titrate up slowly. Allow the body to adjust.
"Glucagon Receptor Activation: Glucagon receptors are present on peripheral nerve endings. Data from clinical trials suggests that when retatrutide binds to these receptors—particularly at higher doses—it can trigger abnormal, spontaneous firing in the sensory nerves right below the skin. This is why retatrutide has a significantly higher rate of dysesthesia (up to 21% at maximum doses) compared to single-hormone alternatives."@EXTROPIAN I have to disagree, my research with my own experience. Same dose various vendors and I've experienced this only with half of them. So I have to assume it's the supply not the dose.
Just someone with a fridge full of research and a browser history that would concern my doctor.
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@EXTROPIAN I have to disagree, my research with my own experience. Same dose various vendors and I've experienced this only with half of them. So I have to assume it's the supply not the dose.
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@EXTROPIAN I have to disagree, my research with my own experience. Same dose various vendors and I've experienced this only with half of them. So I have to assume it's the supply not the dose.
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I've only used Reta from two different U.S. resell vendors; Compound Sciences and Crush. Both are effective and I did experience sunburn sensation including what I would describe the beginning symptoms of Shingles, (intermittent stinging nerve pain similar to fire ant stings.) None of these symptoms lasted very long, and after I got above the 2.5mg weekly dose, it hasn't returned. I will say I've experienced Shingles like nerve pain intermittently just out of the blue a few times a year ever since I had Shingles ten years ago, so maybe I'm just sensitive to products that are known for these side effects.
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@BeeKind what was the lowest dose you has dysesthesia? I experiences it on my first 3mg.
3mg. Now is my last 2mg Reta. A week ago I added Tesa 1mg and entire body has dysesthesia. Rating 1 to 10 its a 4 in intensity but I do feel it. I stopped and its going away. I am about to exit Reta so I shelved tesa. I really dont need it. I was just curious. As for tesa, just fast over night and you'll lose weight for sure. Not as fast but you will. Just stop eating the 'slop.
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3mg. Now is my last 2mg Reta. A week ago I added Tesa 1mg and entire body has dysesthesia. Rating 1 to 10 its a 4 in intensity but I do feel it. I stopped and its going away. I am about to exit Reta so I shelved tesa. I really dont need it. I was just curious. As for tesa, just fast over night and you'll lose weight for sure. Not as fast but you will. Just stop eating the 'slop.
@EXTROPIAN I had to stop reta. My last pin was last Thursday. The skin sensation was not going away. I held out for a month, and it became so bothersome I couldn’t sleep. I don’t know if I will try again with another vendor as some here suggested or just do Randy’s ghetto reta with tirz and maz/sourvo.
It’s been a week, and it’s still there, though. I’m kinda afraid the skin thing won’t ever go away. In the papers, it says ‘most’ people with the symptom see it resolve after discontinuation. I’m not being a baby about it. In fact, I probably let it go on too long just because I wanted very badly to like reta. Just walking is uncomfortable with the fabric moving against my legs. Sigh. -
@EXTROPIAN I had to stop reta. My last pin was last Thursday. The skin sensation was not going away. I held out for a month, and it became so bothersome I couldn’t sleep. I don’t know if I will try again with another vendor as some here suggested or just do Randy’s ghetto reta with tirz and maz/sourvo.
It’s been a week, and it’s still there, though. I’m kinda afraid the skin thing won’t ever go away. In the papers, it says ‘most’ people with the symptom see it resolve after discontinuation. I’m not being a baby about it. In fact, I probably let it go on too long just because I wanted very badly to like reta. Just walking is uncomfortable with the fabric moving against my legs. Sigh.@jennn I assure you it will go away but did wonder what if. It take a few weeks but it does go away. I resently stopped tesa because i got it again and it is going away. And I thought it was a glucagon thing. It was more prominent on my abdoment and legs where I pin. Maybe it was the body telling me something. "Pss we are here already" I am happy with the results.
When I got it with Reta at 3mg. Yes it was so uncomfortable. And yes I was wondering if it was.going away. I did try 3mg again and it didn't happen but personally it felt like the 2mg. I am curious why tesa gave me dys' if it wasn't the glucagon. I did read somewhere that tesa does as well. Answer was fluid compression against nerves. -
I've been on reta for almost a year. I get this sensation on my scalp, sometimes part of my face and my forearms and hands. Intensity varies but it has never been super bad. However, now at 5mg and it still hasn't vanished.
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