A PRELIMINARY RETA EXIT.
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Today is the day. Instead of 1mg I went for .5mg, the tapering starts. I was talking to a friend and she said after a couple of months of 1-1.5mg she was off for over a month and didn't have a hunger attack. She has been getting off the slop before reta, as I. If there is a rebound I want to feel it. Bring it!
@EXTROPIAN Takes more than a month to completely clear from your system.
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@EXTROPIAN Takes more than a month to completely clear from your system.
@Elysium2132 Yep. It takes 4.5 half lives of a drug to reach steady state or to be eliminated from your system, assuming first order (linear) kinetics. This puts reta at 27 days for elimination with a half life of 144 hours.
Half-Life Comparison
• Tirzepatide: Approximately 5 days (120 hours). It is a dual GLP-1 and GIP receptor agonist.
• Retatrutide: Approximately 6 days (144 hours). It is a triple GLP-1, GIP, and glucagon receptor agonist.
• Survodutide: Approximately 4.5 to 6 days (109 to 144 hours). It is a dual GLP-1 and glucagon receptor agonist.
• Mazdutide: Approximately 7 to 9 days (ranging up to ~8 days in clinical evaluations). It is a dual GLP-1 and glucagon receptor agonist. -
@EXTROPIAN Takes more than a month to completely clear from your system.
@Elysium2132 OK let's do some numbers. If Retatrutide was given a half life of 6 days. That means by the 6 day it will be 50% in concentration in the body. So does this mean the other 50% will be cleared by next week? Reta was design to shield itself from an enzyme (dpp-4) that specifically targets glp, gip. Without the shield glp and gip will be eliminated in minutes. And they also added this fatty acid chain to the molecule to bind to albumin. So the question is. If the biological half-life of albumin in the human body is approximately 18 to 21 days. This means half of the protein is broken down and recycled every three weeks. Note that if retatrutide was left undisturbed it will continue to do what it does indefinitely bindingnto receptor cells for a few minute and on to the next one, like a pimp. There are still other enzyme (proteases and peptidases) circulating in the blood system and tissues that breaks it down before itnis filtered through your liver. So what is the half life 6 days or 18-21 days? If it is 18 to 21 half life because it is attached and circulating with its buddy albumin. Then why am I pinning every week? If it takes over a month to completely clear out of my system. Where is it in the body? It just doesn't add up. But this I can confirm. From 2mg to .5mg on the first week of tapering. Food is starting to taste pretty good. The supressed dopamine, endorphines are starting to fire up, serotonin is still holding its ground.
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Yeah my plan was tapering off slow. Try to get under 2mg so i can maintain on a 10mg kit. Then double the bac and get into mcgs until zero.
@quicksilver80
were u taking 2 mg once a week? -
Second day with .5mg. I am not hungry but as soon as I took the first bite it taste sooo good. I am still filling up quick. Stomach feels kinda raw. Tomorrow I am going to do some key amino acids see if it makes any different.
Can I ask what company u order from? Ive been burned by stuff that the peptide isnt even in it. No change for 2 months. I need a legit company
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Can I ask what company u order from? Ive been burned by stuff that the peptide isnt even in it. No change for 2 months. I need a legit company
@lorihinson So many good vendors to choose from. If you want the cheapest kit (10 vials at a time) Nexaph.com is the way to go.
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Good time to look into ss31 and mots-c if dropping reta gives you any issues.Do your research, get your testosterone optimized, will be the best approach.
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Can I ask what company u order from? Ive been burned by stuff that the peptide isnt even in it. No change for 2 months. I need a legit company
@lorihinson It use to be Peptide Sciences (Shut down) and most recent Peptide Hackers from California. I still have the Peptide Hackers kit of Reta 10mg. I also have gotten plenty of sample from this girl in my building that just started her own pep business under LuxElite peptides. My most recent kits are straight from China. No issues, yet. The few I have shared with are satisfied. I have a list of peps I would like to try. I'll be giving Peptide Cridic list of vendors a try soon.
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@quicksilver80
were u taking 2 mg once a week?@lorihinson im currently at max dose. Im planning to taper down once i get down to my goal weight. I started at 2mg though several months back.
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@lorihinson im currently at max dose. Im planning to taper down once i get down to my goal weight. I started at 2mg though several months back.
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@quicksilver80 max dose at 4mg or the rediculous 12mg?
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I split dose, 1.5mg every three days to try to reduce the pressure and valleys, and reduce nausea. Down 16 pounds in 1.5 months. Is anyone else doing a split dose protocol, is it more or less effective? I didn't start that way, but titrating up on the 7 day protocol was making me sick.
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@EXTROPIAN 12
Wow that's crazy. How long have you been on it? Did you follow the absurd trial titration?
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I split dose, 1.5mg every three days to try to reduce the pressure and valleys, and reduce nausea. Down 16 pounds in 1.5 months. Is anyone else doing a split dose protocol, is it more or less effective? I didn't start that way, but titrating up on the 7 day protocol was making me sick.
I split dose, 1.5mg every three days to try to reduce the pressure and valleys, and reduce nausea. Down 16 pounds in 1.5 months. Is anyone else doing a split dose protocol, is it more or less effective? I didn't start that way, but titrating up on the 7 day protocol was making me sick.
I've split dose the whole time. So I dont have real world experience to compare. Although not the same, I was on Tirz once weekly dose last year. For comparison I like the split dose Reta better. With Tirz once weekly I couldn't eat after taking and starving a day or 2 before next dose. Didn't like the peaks and troughs. Smooth sailing this year. You also answered your own question. This is what worked for you so that is what was effective. I dont know how much weight you have to lose but 2.5 pounds per week sounds like a great place to be.
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@quicksilver80 man I walked in to that one as well. I heard the trail 12mg but never met anyone who has. What are the effects at 12mg?
@EXTROPIAN just more of the same. Maybe a little more rhr. Never hungry. Just getting expensive to feed it is the worst side effect.
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@EXTROPIAN 12
Wow that's crazy. How long have you been on it? Did you follow the absurd trial titration?
@Mydogdaryl423 been almost 8.5 months? Yeah titrate 2mg every 4 weeks. May have stayed at 8mg longer than the rest because i got into some gastro sides.
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@quicksilver80 I bet you did. You are the only person that Ive heard so far that went that high. The difference in the results in the trials from 10mg to 12mg was tiny but the side effect difference was huge. I maxed at 8 for a short period of time. I was always looking for the lowest effective dose. Started at .5mg twice a week. By week 16 I was at 2mg twice a week.
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@quicksilver80 I bet you did. You are the only person that Ive heard so far that went that high. The difference in the results in the trials from 10mg to 12mg was tiny but the side effect difference was huge. I maxed at 8 for a short period of time. I was always looking for the lowest effective dose. Started at .5mg twice a week. By week 16 I was at 2mg twice a week.
@Mydogdaryl423 yeah get on meso. Ive seen higher. So im not too worried. 20 more pounds and ill start bumping down.
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@Mydogdaryl423 yeah get on meso. Ive seen higher. So im not too worried. 20 more pounds and ill start bumping down.
@quicksilver80 So, you are on 12mg of reta now? What was your starting weight?
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