GHK-Cu Subcutaneous Research Dosing Protocol
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@peptidepete - take all of this with a grain of salt as my background is in physics, not chemistry.
Also, just to be clear: your body your rules
Just thought it might be useful to someone to see how one semi-misguided physicist thought about the issue 
I always consider copper toxicity. But I don't fear it, I evaluate my risk.
If one trusts wikipedia then GHKCU has a molecular mass of 340.38 g/mol and a chemical formula of C14H24N6O4 - the important detail from which is that it has one Cu atom. Copper's atomic weight is 63.546 - meaning that's roughly the contribution of that single copper atom to the molecular mass of GHKCU.
So GHKCU is 64.546/340.38 = 0.1896292379 % copper by mass. Lets call it 19% for conversational purposes.
So 10mg per day of GHKCU is ~1.9mg of copper per day.
So the question is: is that a lot? is it enough to cause copper toxicity?
NIH recommendations for copper intake are about 0.9 mg per day. Please note that is likely for food... which means you would need to consider absorption (zinc competes). Please also note you get copper from your food as well.
So off the cuff - I'd worry enough to look deeper about taking 10 mg of GHKCU (1.9 mg of copper) per day. Panic - no. But I'd look more deeply into issues of bioaccumulation, how badly NIH is lowballing copper recommendation, absorption rate corrections for the NIH's recommendation etc.
Please note: I do take 2mg per day of GHKCU - but that 380 mcg (0.38 mg) doesn't worry me particularly.
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When researching, quantify the risks
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@peptidepete - totally agree. That's why I also run copper rbc to try to capture cellular copper levels as well
Speaking of which UltaLabs is a super easy (and cheap... often cheaper than with insurance) way to run your own lab tests. I'm checking my copper rbc (along with many other things) monthly currently. I don't expect to see it go out of range... but I'm cautious
Good to run standard liver and kidney markers as well... I recently discovered that way I was getting a little too happy with the glutathione, and paradoxically if you take that one to far, your liver enzymes can get grumpy... so I have backed off.
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@diegoc For the moment I've cut out my glutathione subq until my next monthly blood work shows my liver enzymes go back to normal. That would confirm my hypothesis and allow me to look at some re-introduction. Previously I'd been doing ~ 50mg morning and evening daily (100mg per day) and biweekly 1200mg glutathione IVs. In retrospect that dosing was always probably pushing things... but it was one of the things I could feel immediately in my body positively, so I got carried away
As to the 2mg vs 10mg of GHKCU. I've never gone about 2mg per day, so I can't speak to the 10mg utility (that's a question for @peptidepete ). I am doing the 2mg per day for general healing and skin and hair. I have received complements since starting it on my skin appearance, but I also have a lot of other things in motion positively, so am reluctant to solely ascribe that to GHKCU.
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@peptideed now im intrigued and very interested. Lol
Right now im injecting 2mg GHK- which i will upload my crazy madness way (painfree) im also doing a Timeshift face cream with some GHK and on Thursday I receive some mouth strips…. Thats my secret weapon, whats yours.
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Folks understandably ask "why" the heroic dosing. To see what is on the other side is the answer
Strikes me as a reasonable experiment. Primary curiosity- assist in keeping my post-GLP3 skin tight. I am only looking to lose my ~20lbs of visceral fat but still getting some "drapy" skin nevertheless. Also, will it affect my male pattern baldness. I experienced no negative sides on daily 7.5-10mg GHK-Cu.Pain, yes, it can vary between nothing, and 24-36 hours not sleeping on that side pain...lol. For me the upper-outer quadrant of the buttock is where the magic is. Belly/Midriff area inevitably gets me a lump, sometimes for weeks.
Will update thread as time passes- cheers
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Update- Continuing with 10mg GHK-Cu per day, every day. Sub-Q. Typically upper/outer quadrant of buttock and especially just above the buttock between where where the love handles used to be and the top of the cheek, about an inch or so wide.
No negative sides. No longer have ISR (seriously I do not). My skin looks freaking awesome and feels like silk, my perpetual heel calluses are no longer cracking. As a man's man (lol) who has never done any kind of skin care, my skin to me is a reflection of overall health, ergo the high-dose GHK is justified.
Now I wonder what 15-20mg per day would result in? Crazy talk!
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@peptidepete Take this with the affection intended: watch your copper rbc numbers
You are probably fine. But its too cheap a hedge not to take -
@peptidepete Take this with the affection intended: watch your copper rbc numbers
You are probably fine. But its too cheap a hedge not to take @PeptideEd said in GHK-Cu Subcutaneous Research Dosing Protocol:
@peptidepete Take this with the affection intended: watch your copper rbc numbers
You are probably fine. But its too cheap a hedge not to take Will do
Labs coming up in approx 30 days. Copper is on that. Always good to stay on top of comprehensive lab work when researching aggressively!PS- Grok (which is very good for peptide stuff) has this to say:
"The likelihood of experiencing copper-related problems (such as toxicity or overload) from dosing 10 mg of GHK-Cu daily appears to be low for most healthy adults without pre-existing conditions like Wilson's disease or copper metabolism disorders. Here's a breakdown of the reasoning: Copper Content in GHK-Cu (glycyl-L-histidyl-L-lysine copper) contains approximately 15-19% elemental copper by weight, depending on the exact formulation.
At 10 mg of GHK-Cu, this equates to roughly 1.5-1.9 mg of elemental copper per dose.
The Recommended Dietary Allowance (RDA) for copper in adults is about 0.9-1.3 mg per day, primarily from diet. Average daily dietary intake is 1-1.6 mg.
The Tolerable Upper Intake Level (UL) for elemental copper from all sources (diet + supplements) is 10 mg per day for adults, per health authorities like the NIH. Exceeding this chronically can increase risks, but 10 mg GHK-Cu adds only ~1.5-1.9 mg, bringing total daily copper (including diet) to around 2.5-3.5 mg—well below the UL."Looking good for that boost to 20mg!
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@peptidepete Take this with the affection intended: watch your copper rbc numbers
You are probably fine. But its too cheap a hedge not to take @PeptideEd hey bud, are you going to give us some of your copper tricks of the trade?
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@diegoc LOL - I don't feel like I'm that sophisticated a GHKCU user... but the meager tricks I do have I'm happy to share.
I get my blood work done via Ultalabs which uses Quest under the covers. The two tests I do roughly monthly for copper are:
- Copper RBC - which is a decent proxy for cellular copper status - I use this to watch out for copper toxicity.
- Zinc RBC - which I use to check zinc cellular levels.
Having the Zinc/Copper ratio to far out of balance leads to all kinds of downstream mischief... independent of actual copper toxicity. In my case my zinc rbc pointed to the need to supplement zinc more than I had been doing.
My only other trick really is to dilute with more bac water to reduce stinging as @randy recommended in this video.
Hope some of that helps
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Just a little update on me. Im doing 3mgs a day now. Might go to 5 for the culture. If one of you goes to 20 ill have no choice but to go to 21.
@Randy said in GHK-Cu Subcutaneous Research Dosing Protocol:
Just a little update on me. Im doing 3mgs a day now. Might go to 5 for the culture. If one of you goes to 20 ill have no choice but to go to 21.
LOL!I remain on 10mg daily and my wife got pissed at my skin and demanded to start pinning it even though she does not care for multiple shots per day. She tolerated 2.5mg with no ISR and I bumped her to 5mg where she is now.
I am finishing off 63mg vials with 3ml BAC, then I dilute again in the inj syringe prior to pinning.
I really like Dr Kristi Sawicki on YT, smart independent thinking person: Link
Her perspective on GHK and cancer, with her background, is quite thought provoking. Quite...
