Glutathione (GSH) Subcutaneous Research Dosing Protocol
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@keurimm My rat prefers his Glutathione IM, 400mg-500mg 3x per week in the thigh or glute. It's good stuff! Haven't been sick once, no seasonal allergies and skin that's never looked better.
@mrjoshua44 I guess I could go do the math on the calculator but wondering how you are reconstituting to get that dose. Any burn like copper or NAD?
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@mrjoshua44 That is exactly what I bought…how many ml of bac water and units are you planning on running?
@beachfun I used 9mL's of GTB water since it was my first time reconstituting glutathione. Probably could've used less but that's ok. Haven't tried it yet, my first dose will be later today. But that GTB water has taurine in it so it's supposed to take the bite out of the shot. Anyway, I have my dose set at 200mg which in this concentration is 150cc/units or 1.5mL. But since I normally pin 400mg 3x a week, I'll be pushing 300cc/units or 3mL's IM.
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Yay! Just got a couple of purple tops delivered.
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I would LOVE to do Glutathione subq. I got infusions which had more B12 than anything, IMO. Please let me know if you dd subq and your recipe and how it turned out.
I asked my Dr. about this, "Since Gluta speeds up detox in phase two, it shouldn't speed up the detox of other peptides, should it?" She didn't know how to answer this; wasn't sure.
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This post is deleted!
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I would LOVE to do Glutathione subq. I got infusions which had more B12 than anything, IMO. Please let me know if you dd subq and your recipe and how it turned out.
I asked my Dr. about this, "Since Gluta speeds up detox in phase two, it shouldn't speed up the detox of other peptides, should it?" She didn't know how to answer this; wasn't sure.
@Eleanor I mainly pin my Glutathione IM in either my thigh or glutes. And that's due to the volume of the injection. I just reconstituted a 1200mg vial the other day using GTB water (Glutathione Transport Bacteriostatic Water). I used 9mL's of GTB. So that solution came out to be 133.33mg/mL and my dose is 200mg. And that worked out to be 150 Units or 1.5mL. I try not to pin anything SubQ that's going to be more than 100 units or 1mL. Next time I'm going to decrease the amount of mL's used to reconstitute it. To answer your second question, no. It does not affect other peptides.
Here is why it doesn't arbitrarily speed up the detox/clearance of other peptides:
Different Processing Pathways: Peptides are chains of amino acids. The breakdown and clearance of specific functional peptides are generally handled by specialized enzymes (like peptidases and proteases) spread throughout the blood and tissues, not just the liver's Phase 2 detox pathways.
Specialized Conjugation: In Phase 2, Glutathione S-transferase (GST) enzymes only attach glutathione to specific electrophilic (reactive) toxins or free radicals to make them water-soluble. It generally does not bind to or speed up the degradation of beneficial peptides.
Biological Targets: Rather than breaking other peptides down, Glutathione often interacts with them synergistically. It serves as a master antioxidant to protect them from free radical damage and oxidative stress so they can properly bind to their intended cell receptors.
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@Eleanor I mainly pin my Glutathione IM in either my thigh or glutes. And that's due to the volume of the injection. I just reconstituted a 1200mg vial the other day using GTB water (Glutathione Transport Bacteriostatic Water). I used 9mL's of GTB. So that solution came out to be 133.33mg/mL and my dose is 200mg. And that worked out to be 150 Units or 1.5mL. I try not to pin anything SubQ that's going to be more than 100 units or 1mL. Next time I'm going to decrease the amount of mL's used to reconstitute it. To answer your second question, no. It does not affect other peptides.
Here is why it doesn't arbitrarily speed up the detox/clearance of other peptides:
Different Processing Pathways: Peptides are chains of amino acids. The breakdown and clearance of specific functional peptides are generally handled by specialized enzymes (like peptidases and proteases) spread throughout the blood and tissues, not just the liver's Phase 2 detox pathways.
Specialized Conjugation: In Phase 2, Glutathione S-transferase (GST) enzymes only attach glutathione to specific electrophilic (reactive) toxins or free radicals to make them water-soluble. It generally does not bind to or speed up the degradation of beneficial peptides.
Biological Targets: Rather than breaking other peptides down, Glutathione often interacts with them synergistically. It serves as a master antioxidant to protect them from free radical damage and oxidative stress so they can properly bind to their intended cell receptors.
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@mrjoshua44 Thank you, Sir! Excellent information. I don't like IM's because as a redhead, I bruise easily and I never seem to get the poke 100% right.
How many times per week to you pin?
@Eleanor 3x per week.
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@beachfun I used 9mL's of GTB water since it was my first time reconstituting glutathione. Probably could've used less but that's ok. Haven't tried it yet, my first dose will be later today. But that GTB water has taurine in it so it's supposed to take the bite out of the shot. Anyway, I have my dose set at 200mg which in this concentration is 150cc/units or 1.5mL. But since I normally pin 400mg 3x a week, I'll be pushing 300cc/units or 3mL's IM.
@mrjoshua44 I have that Korean Glutathione but not the bac water for it. Going to the clinic tomorrow so will see if they can get me started. Thanks so it looks like a IM shot
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@beachfun I used 9mL's of GTB water since it was my first time reconstituting glutathione. Probably could've used less but that's ok. Haven't tried it yet, my first dose will be later today. But that GTB water has taurine in it so it's supposed to take the bite out of the shot. Anyway, I have my dose set at 200mg which in this concentration is 150cc/units or 1.5mL. But since I normally pin 400mg 3x a week, I'll be pushing 300cc/units or 3mL's IM.
@mrjoshua44 I have that Korean Glutathione but not the bac water for it. Going to the clinic tomorrow so will see if they can get me started. Thanks so it looks like a IM shot
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Yay! Just got a couple of purple tops delivered.
@mrjoshua44 I just got some from Puratek as well (they ran a great special) this is how I learned about the purple caps...Product is great so now I'm on the hunt for a more direct supply. ANYONE GOT A LEAD?
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@mrjoshua44 I just got some from Puratek as well (they ran a great special) this is how I learned about the purple caps...Product is great so now I'm on the hunt for a more direct supply. ANYONE GOT A LEAD?
@rafdanelczyk
Well, I went to the clinic and they charged me $250 for a 50mg premixed vial of glutathione. Im looking too… -
I dropped this link in another conversation but wanted to share here. This is where I’ve gotten my Korean glutathione from for years. It currently $60 for a case of 10. $30 shipping no matter what you order. I haven’t placed an order since tariffs went into place. I know they use to mark a package value at 10% of what you paid.
https://www.acecosm.com/categories/health-booster/ki-glutaone-inj-glutathione-1200mgI dropped this link in another conversation but wanted to share here. This is where I’ve gotten my Korean glutathione from for years. It currently $60 for a case of 10. $30 shipping no matter what you order. I haven’t placed an order since tariffs went into place. I know they use to mark a package value at 10% of what you paid.
https://www.acecosm.com/categories/health-booster/ki-glutaone-inj-glutathione-1200mgI ordered a kit last week for acecosm it arrived Monday thanks for the link @myb
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So does this need to be refrigerated after being reconstituted, or are you guys just keeping it in a "cool, dark place?"
Also, I'm assuming you can filter glutathione just like any other peptide? I plan on reconstituting my first vial tonight. I plan to use 9ml of hospira BAC in a 1500mg fuan and then filter it into a fresh 10ml vial.
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It needs to be refrigerated once reconstituted (not while still lyophilized), otherwise it is happy to quickly degrade at room temp. I warm a vial under my armpit for a couple minutes to get it to flow. For SURE keep it away from light.
Gluta is one of the few I do not filter because I'm either using pharma (Fuan) or I've conducted my own testing. As far as I know it is filterable.
I use 7ml diluent only for the fact I want minimum 400mg+ (my daily dose) gluta in two 100 unit pins. Less viscous with 9ml that's for sure, and if you are using lower doses it is a good choice.
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Thanks for the clarification. I ended up filtering it just to be safe. 2 doses in and so far no sting or ISR's so 9ml seems to do the trick. Still only at 100mg 3x a week though. Probably bump up to 200 next week and then 300 the week after if all goes well. My rat has higher than normal lead levels due to work so I'm interested to see if glutathione helps at all. Been taking NAC daily aswell.
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@beachfun do you have IV infusion places in your area. Highly recommend glutathione IV infusion over shots, if you’re going the clinical route.
@MyB WHATS THE DOSE ON IV INFUSION. I HAVE ACCESS TO DO IN HIME INFUSIONS BUT DON'T KNOW THE DOSAGE AND FREQUENCY. I HAVE 1500MG -FUAN
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W WisGal64 referenced this topic on
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Hi guys been researching a lot on Glutathione. I’m particularly intersted in its effects on combating oxidative stress and its ability to combat the effects from heavy medication like accutane. Saying that do you think a dosing schedule of 100-200 mg Sub-Q 2-3 times a week is practical for combating the liver stress caused by accutane?
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Just got my delivery, I thought I should test these out since everyone is raving about them. I've never tried sub Q only transdermal Glutaryl by Auro.
Question to the community, is glutathione transport bac water necessary or just optimal? I can't seem to find any.
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