Tesamorelin cycling
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@vpeps @beekind I started with a Tesa/Ipa cycle but stopped the Ipa part after 2 weeks. I didn't like the way I felt (suspect is was mostly water retention) and decided it was either the Tesa or Ipa or both. I stopped the Ipa (and the side effects went away) but have continued the Tesa on the same 5/2 schedule. I feel much better on just the Tesa and decided to extend that cycle to 16 weeks. That has been my experience, but your mileage may vary.
@vpeps @beekind I started with a Tesa/Ipa cycle but stopped the Ipa part after 2 weeks. I didn't like the way I felt (suspect is was mostly water retention) and decided it was either the Tesa or Ipa or both. I stopped the Ipa (and the side effects went away) but have continued the Tesa on the same 5/2 schedule. I feel much better on just the Tesa and decided to extend that cycle to 16 weeks. That has been my experience, but your mileage may vary.
It wasn't the Ipamorelin. It was too high of a dosage of both causing the water retention, a side effect of excessive GH levels. Ipamorelin makes Tesa work that much better. Stopping the Ipa just lowered your GH levels enough to reduce the side effects from GH. You'd be better off actually taking less Tesa, because its not only the one moving most of the load here, it's also a lot more expensive (and comparing the two, has more side effects, like antibody build-up, which Ipamorelin doesn't seem to have).
As far as your 5/2 cycle protocol, it's not the most effective way to go about it, see above and my posts in this thread.
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@BeeKind Good question, I wonder how much it can help versus just Tesamorelin. Maybe it can allow to use a lower dose of Tesa, for example instead of 1.5 mg a day use 1.0 mg + 0.2mg Ipa (I just guess the numbers) to get the same IGF1 boost with less Tesa side effects, also a bit cheaper. The trade-off is that you have to make pauses with Ipa.
@BeeKind Good question, I wonder how much it can help versus just Tesamorelin. Maybe it can allow to use a lower dose of Tesa, for example instead of 1.5 mg a day use 1.0 mg + 0.2mg Ipa (I just guess the numbers) to get the same IGF1 boost with less Tesa side effects, also a bit cheaper. The trade-off is that you have to make pauses with Ipa.
Your thinking is correct here regarding using Ipamorelin "to get the same IGF1 boost with less Tesa side effects, also a bit cheaper". You need to make pauses with Tesa too (see my responses above about antibody build-up over time).
But I'm with you, I think the doses most are using with Tesa are exceedingly too high. Everyone's basing it on the clinical research using 2mg, but remember, that was based on a sick cohort of users who also were using outdated, less effective methods who needed that kind of dosing to overcome their obstacles. What were they? Multiple comorbitities including HIV, weren't pinning it around fasted windows, didn't pair it with Ipamorelin, and very likely weren't health conscious fitness people.
I suspect that if you correct the mistakes made in the trials with more advanced protocols and a healthier user base, the dosages needed for a favorable response are much, much lower than the 2mg used. Pairing it with Ipamorelin, I'd start with 500mcg and adjust up from there.
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@vpeps @beekind I started with a Tesa/Ipa cycle but stopped the Ipa part after 2 weeks. I didn't like the way I felt (suspect is was mostly water retention) and decided it was either the Tesa or Ipa or both. I stopped the Ipa (and the side effects went away) but have continued the Tesa on the same 5/2 schedule. I feel much better on just the Tesa and decided to extend that cycle to 16 weeks. That has been my experience, but your mileage may vary.
@coondogesq I have researched CJC/ipa, tesa, and serm, and it’s definitely the tesa that causes swelling and pain. If/when I research it again, I’ll take a lower dose.
I ran the clinical 2mg dose and next time I will run 1mg tesa and maybe 250mcg ipa as there is a lot of recent buzz about that and everybody here seems happy with the results vs other protocols I’ve tried with limited results.
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@neil-mccauley do you think 500mcg tesa/250mcg ipa separately w tesa am ipa PM would be a good starting range?
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I would personally run one at a time to see the difference of each compound separately in different cycles.
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@neil-mccauley do you think 500mcg tesa/250mcg ipa separately w tesa am ipa PM would be a good starting range?
@neil-mccauley do you think 500mcg tesa/250mcg ipa separately w tesa am ipa PM would be a good starting range?
Do them both at same time. Ipamorelin is going to suppress somatostatin tone which will help not only increase the GH pulse from Tesa but also extend the pulse tail, thus resulting in more GH released. Separating them destroys the synergy, and is just more work, more pinning, more supplies, etc.
I'd use a much lower dosage of Ipamorelin to start too. If you have the 10/3 blend, that's going to be 500mcg/150mcg. 150 seems low, but remember receptor saturation point starts at 1mcg/kg, so thats double that amount. If you're pulling them out of separate vials, I'd go 500/100.
Remember, the higher the Ipa dosage the faster/more receptor desensitization will occur (and probably the same can be said about antibody build-up with Tesa). So it really is important to use lower end dosages and use outside methods to help things work synergistically.
This is why I think really being strict about your fasted windows is hugely beneficial (3 hours prior/2 hours after). This will help amplify response and lesson the need for ever increasing dosages. Also, utilizing a 30 day cycle break after 90 days. Exercise is huge, as it lowers fasted insulin/glucose, again, allowing for a more favorable GH response. I think eating a higher protein, less junky carb diet and staying away from all day grazing/snacking and tightening up meal windows with no snacking in between is critical. So is DHEA supplementing if levels are < 300 (improves insulin sensitivity and helps restore GH pulse via several mechanisms).
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@neil-mccauley Appreciate the clarity in these posts.
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@neil-mccauley Thank you, sir!
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@neil-mccauley @researchcat While I’m only doing 1 mg of Tesa, I suspect you may be tight that the aggregate of the two was too high. Stopping one dropped it to a more tolerable level. Which one I stopped may have been somewhat arbitrary at the time. Now that I’ve been on the Tesa for 7 weeks, it might make sense to add the ipa back. Going to daily be 5/2 makes some sense for the rest of my planned 14-16 week total Tesa cycle. Open to thoughts and advice. One of the reasons I like the exchanges here.
As far as impact, tough to say for sure but my waist size is down 2 inches since starting Tesa and 6 inches since starting Reta the first week of June. The last two inches were with much less accompanying weight loss. I’m also noticing more rem and deep sleep time since starting Tesa.
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Question about recon Tesa. I usually filter with .22 micron filter when transferring from vial to pen vial.
However, I’ve recently read that since Tesa is a large fragile molecule, filtering is not recommended.
Is there any truth to that? @randy always filters and those videos are what got me on the filtering train….
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Question about recon Tesa. I usually filter with .22 micron filter when transferring from vial to pen vial.
However, I’ve recently read that since Tesa is a large fragile molecule, filtering is not recommended.
Is there any truth to that? @randy always filters and those videos are what got me on the filtering train…. -
I take Tesa 2mg / Ipa 6 days a week. The only reason I don’t take it 7 days a week is because I take Reta 2mg weekly. The night I take the Reta I don’t take anything else (at night). I havr been on it straight for 7 months and it has worked wonders. I don’t plan on stopping… I may drop the ipa here and there, but not the Tesa. It isn’t cheap, but nothing good is.
Please excuse my typos. Small Phone & Bad Eyes
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I take Tesa 2mg / Ipa 6 days a week. The only reason I don’t take it 7 days a week is because I take Reta 2mg weekly. The night I take the Reta I don’t take anything else (at night). I havr been on it straight for 7 months and it has worked wonders. I don’t plan on stopping… I may drop the ipa here and there, but not the Tesa. It isn’t cheap, but nothing good is.
@Commander How much Ipa are you doing with the 2mg of Tesa?
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I take Tesa 2mg / Ipa 6 days a week. The only reason I don’t take it 7 days a week is because I take Reta 2mg weekly. The night I take the Reta I don’t take anything else (at night). I havr been on it straight for 7 months and it has worked wonders. I don’t plan on stopping… I may drop the ipa here and there, but not the Tesa. It isn’t cheap, but nothing good is.
@Commander
What do you think would happen if you stopped tesa?
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