SS-31 (Elamipretide) — Research Dosing Protocol
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@researchcat My game plan is to take ATX-0304, then layer in SS-31, and then transition to MOTS-C. I'll add NAD+ at some point.
My curiousity was around the effective dosage for SS-31.
I'm 48. I'm looking at SS-31 like an oil change for my mitochondria, not an engine overhaul. I've seen claims that 40mg daily of SS-31 has the same effect as 4mg daily for most people.
Here is a video recommending 5-10mg/day.
https://www.youtube.com/watch?v=cjUm5gkSwRkHere is an article recommending 5mg/day.
https://www.innerbody.com/ss-31-peptideIf that is the case, that is a huge cost variance from the protocol Randy posted above - Roughly 300mg vs 1000mg over a 60 day period.
I was curious if people felt like sticking with the 4-5mg dose for 60 days was effective, based on their research.
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As mentioned above, I just completed Phase 1 and 2 of the protocol Randy recommended (~300mg total). It’s hard to say with certainty how effective it is given my goal was to seek long term benefits that are not easily measurable, and that I am researching MOTS-C and NAD+ now.
I’d suggest trying the lower dose protocol and see if you think it benefits you before ramping up to a higher dose. You can always accelerate research if you think it may benefit you more.
Anecdotally, a friend is currently researching the combination SS-31/MOTS-C/NAD+ protocol and aside from getting some tiredness after higher doses, his rat feels amazing.
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Reminded by the @researchcat that I as well experienced tiredness/energy drained feeling upon ramping up dose/frequency of SS31 which subsided and indeed reversed over a few weeks. A feature not a bug methinks.
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This post is deleted!
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I was generally researching before bed, so I didn’t really notice.
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I started the SS 31 and would feel a crash at 4, tried MotsC then crashed again, NAD+ did nothing for me either. This was the low and slow phase while finishing 6 weeks 5 amino 1mq. So tried the Lipo-C with glutathione and WOW!!! All day energy and no crash into the 2nd day. I bought a kit and started 3rd week of Lipo-C with 75 units IM 2xs a week with a great mood too. I will try the 5mg MotsC but was only at 2.5mg but thought Id share my great experience with LipoC and will do SS31 later. Im 62 and working hard on a big kitchen remodel job solo, so I need to feel good to perform well working hard physically.
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Just putting this out there for anyone else with 10x 30mg vials that may want to adopt a similar RandyRat Cycle on their critter:
Phase 1: .4mg x15 days, first 2 vials 1.5mL 20u a draw
Phase 2: 10mg x 12 days, vials 3-6 .6mL 20u draw
Phase 3: 30mg every third day, last 4 vials .5mL 50u draw
I'm starting tomorrow, suggestions are welcome.
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Just putting this out there for anyone else with 10x 30mg vials that may want to adopt a similar RandyRat Cycle on their critter:
Phase 1: .4mg x15 days, first 2 vials 1.5mL 20u a draw
Phase 2: 10mg x 12 days, vials 3-6 .6mL 20u draw
Phase 3: 30mg every third day, last 4 vials .5mL 50u draw
I'm starting tomorrow, suggestions are welcome.
@Stan-Douglas Please keep us posted. No way I would attempt the heavy protocol on my kitty, but the one you posted sounds fairly reasonable. Please confirm your Phase 1 as .4mg? Much thanks and I wish you great success.
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Yep, 400mcg.No it isn't it's 4MG, my bad!
Think I may just do a week of it then add an extra 3 days at 10mg or 1 at 30...
I dunno, still haven't given the uniratasuarus his first dose yet, today.
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By “most demanding,” I mean mainly physiologically demanding, not just expensive.
The pulse phase uses a much larger single dose (50 mg at once), so on dose days some people notice more pronounced short-term effects than they did at 4–10 mg daily. The most common “demanding” effect reported is a temporary fatigue/heaviness or needing extra rest for several hours (sometimes into the next day). Others feel no fatigue at all and only notice benefits. It’s simply a “bigger swing” compared to the steadier daily phases.
It can be demanding monetarily too because 50 mg doses add up quickly, but that wasn’t the main point.
Practical advice: treat the first 1–2 pulse doses as a tolerability test (don’t schedule them before a big training day or important event), then adjust if you notice a consistent post-dose dip.
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