Klotho / FLGR242 (albumin-bound new tech)
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Hey Klotho contingent. So picked up a stash for me and the missus to run 6 months each. Thoughts on using standard dosing every 2 weeks vs half dose weekly. Chime in dudes!
@Stones67 i dont think @vpeptides is correct in his reply to you. Hes not on Klotho @peptidepete is and so im I.
The bottle of Klotho is 10mg and the dose was intended to take 1 bottle 10mg Every 2 weeks.
Some ppl actually take it every 13 days.
If you get the same 10mg dose and split it m, your taking 5mg weekly, its not a higher dose.
I actually take it weekly splitting the dose.
Maybe Pete can chime in to see if he dose 5mg weekly or 10mg every 13 days or 14days
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@Stones67 i dont think @vpeptides is correct in his reply to you. Hes not on Klotho @peptidepete is and so im I.
The bottle of Klotho is 10mg and the dose was intended to take 1 bottle 10mg Every 2 weeks.
Some ppl actually take it every 13 days.
If you get the same 10mg dose and split it m, your taking 5mg weekly, its not a higher dose.
I actually take it weekly splitting the dose.
Maybe Pete can chime in to see if he dose 5mg weekly or 10mg every 13 days or 14days
@diegoc I don't see that your reply is much different than mine, other than you confused micrograms with milligrams. Klotho from Biolongevity Labs is dosed in 10 mcg vials.
But the point of splitting the dose is usually to smooth-out the concentration, but in this case the biggest danger comes from overdosing it. I read it directly from BLL flyer on Klotho.! CRITICAL SAFETY WARNING - DO NOT
EXCEED DOSE
Supraphysiological Klotho causes the OPPOSITE of its
benefits: vascular calcification, hypophosphatemia,
hypokalemia, kidney damage, cardiac arrhythmia, and
endothelial malfunction. The body naturally produces
only -4 mcg/day. NEVER exceed 10 mcg every 2 weeks.It's up to you how you dose it. I wouldn't suggest it to tweak the schedule though. What are you trying to achieve with it?
With albumin half-life of 20 days, if you use 5mcg, then, in 7 days, another 5mcg, and another 5mcg in another 7 days, you may end up with potentially albumin from all 3 injections in the body, with higher concentration from last 2 injections. If you do as suggested, the maximum concentration will not be as high.
You may play with https://peptidesplotter.com/ to evaluate what protocol is safer. Again, it's your body, but I would play safe in this case.
Yes, I'm not using it yet, but it's in my fridge, waiting for its time
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Thanks guys. For clarification I'm asking about split dosing. 5mcg weekly vs 10mcg every 2 weeks. I've heard ya clearly not to exceed the 10mcg/2weeks. Unlike FLGR I'm not trying to be fancy and constantly tweak the dosing and schedule. The question stems from some of the discussion up-thread about dosing and stability after reconstitution. The wifely likes the idea of taking a smaller, weekiy dose. And since we'd split it there's little concern about degradation. I'll let you guys know how this sorts out!
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This is a great thread and I appreciate everyone’s thoughts, experiences, and recommendations. FWIW, I am lurking hard.
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@diegoc I don't see that your reply is much different than mine, other than you confused micrograms with milligrams. Klotho from Biolongevity Labs is dosed in 10 mcg vials.
But the point of splitting the dose is usually to smooth-out the concentration, but in this case the biggest danger comes from overdosing it. I read it directly from BLL flyer on Klotho.! CRITICAL SAFETY WARNING - DO NOT
EXCEED DOSE
Supraphysiological Klotho causes the OPPOSITE of its
benefits: vascular calcification, hypophosphatemia,
hypokalemia, kidney damage, cardiac arrhythmia, and
endothelial malfunction. The body naturally produces
only -4 mcg/day. NEVER exceed 10 mcg every 2 weeks.It's up to you how you dose it. I wouldn't suggest it to tweak the schedule though. What are you trying to achieve with it?
With albumin half-life of 20 days, if you use 5mcg, then, in 7 days, another 5mcg, and another 5mcg in another 7 days, you may end up with potentially albumin from all 3 injections in the body, with higher concentration from last 2 injections. If you do as suggested, the maximum concentration will not be as high.
You may play with https://peptidesplotter.com/ to evaluate what protocol is safer. Again, it's your body, but I would play safe in this case.
Yes, I'm not using it yet, but it's in my fridge, waiting for its time
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@vpeptides Nd whats the time your waiting for, more research on timing and dosing?
Or do you buy first research later?
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Thanks guys. For clarification I'm asking about split dosing. 5mcg weekly vs 10mcg every 2 weeks. I've heard ya clearly not to exceed the 10mcg/2weeks. Unlike FLGR I'm not trying to be fancy and constantly tweak the dosing and schedule. The question stems from some of the discussion up-thread about dosing and stability after reconstitution. The wifely likes the idea of taking a smaller, weekiy dose. And since we'd split it there's little concern about degradation. I'll let you guys know how this sorts out!
-
Thanks guys. For clarification I'm asking about split dosing. 5mcg weekly vs 10mcg every 2 weeks. I've heard ya clearly not to exceed the 10mcg/2weeks. Unlike FLGR I'm not trying to be fancy and constantly tweak the dosing and schedule. The question stems from some of the discussion up-thread about dosing and stability after reconstitution. The wifely likes the idea of taking a smaller, weekiy dose. And since we'd split it there's little concern about degradation. I'll let you guys know how this sorts out!
@Stones67 Albumin breakdown in the body follows a first-order exponential decay, which can be described with formula {initial amount} * (0.5)^({day} / 20)
Assuming all klotho binds to albumin, it will degrade as fast as albumin does. We can easily create a table for both schedules.
It looks like you'll be fine either way, weekly is smoother.
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@Stones67 Albumin breakdown in the body follows a first-order exponential decay, which can be described with formula {initial amount} * (0.5)^({day} / 20)
Assuming all klotho binds to albumin, it will degrade as fast as albumin does. We can easily create a table for both schedules.
It looks like you'll be fine either way, weekly is smoother.
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@Stones67 Albumin breakdown in the body follows a first-order exponential decay, which can be described with formula {initial amount} * (0.5)^({day} / 20)
Assuming all klotho binds to albumin, it will degrade as fast as albumin does. We can easily create a table for both schedules.
It looks like you'll be fine either way, weekly is smoother.
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Slight update. Two of the guys working for bll are running dexas currently for their befores and afters. Should be interesting information.
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@vpeptides i do 5mcg weekly and you stated since the albunin binder last 20 days there is risk of overlap on week 3 and now your stated its smoother.
So which it?
@diegoc well, I didn't know what kind of a curve of the degradation it was, then I researched and it looked at least not worse than the original protocol. I thought the levels stay higher and sharply drop at the end of the period of 19-21 days, in which case the more often dose would lead to an overdose.
At the same time Jay says "the human body only makes about 4mcg of Klotho daily" and "This dose allows you to optimize Klotho levels in a range that keeps it within the parameters of good health (the range of 2.5-15 mcg)". But in my calculation the levels are settled above 22 mcg (not even counting 4 mcg endogenous klotho). So I hope their advice is based on their deep knowledge and experience, and they know what they are talking about. Possibly they take into account that it is not a full-length klotho but a short fragment and its effect is milder.
13 or 14 days period doesn't make a big difference in levels, only the inconvenience of application. 14 days cycle will stabilize at 26 mcg level while 13 days cycle at 27.5 mcg level.
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@diegoc well, I didn't know what kind of a curve of the degradation it was, then I researched and it looked at least not worse than the original protocol. I thought the levels stay higher and sharply drop at the end of the period of 19-21 days, in which case the more often dose would lead to an overdose.
At the same time Jay says "the human body only makes about 4mcg of Klotho daily" and "This dose allows you to optimize Klotho levels in a range that keeps it within the parameters of good health (the range of 2.5-15 mcg)". But in my calculation the levels are settled above 22 mcg (not even counting 4 mcg endogenous klotho). So I hope their advice is based on their deep knowledge and experience, and they know what they are talking about. Possibly they take into account that it is not a full-length klotho but a short fragment and its effect is milder.
13 or 14 days period doesn't make a big difference in levels, only the inconvenience of application. 14 days cycle will stabilize at 26 mcg level while 13 days cycle at 27.5 mcg level.
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@vpeptides i understand but they asked a question and you made a statement , i guess without doing the research.
Only when i told you, you changed to that it was more stable.
@diegoc yes. But it is safe to suggest to stay within guidelines, even without a research. It's a proper advice, especially when this particular product has a big letter warning "Do not overdose". Also, maybe those seesaw levels of 14-days cycles are useful too. Some treatments benefit from levels going up and down, and they will be smoothed out with 7-day cycle. I simply don't know, do you?
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@diegoc yes. But it is safe to suggest to stay within guidelines, even without a research. It's a proper advice, especially when this particular product has a big letter warning "Do not overdose". Also, maybe those seesaw levels of 14-days cycles are useful too. Some treatments benefit from levels going up and down, and they will be smoothed out with 7-day cycle. I simply don't know, do you?
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And also im in the belief which i have been doing Testosterone over 15-20 years.
Everything in low dose with more frequency gives more stable BW. So i do daily test shots, when i did Reta i did EOD and mostly all the peptides i have taken or take are done daily, in there own pens or syringes.
Thats why FLGR has a long binding and they see better results with more frequency dosing.
Thats why i keep on telling you i give information and what I personally do or have tested, not second hand info or research
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@vpeptides i usually dont like to suggest if im not doing it myself or have the research.
Ive done Klotho for 5months and i have always dosed it weekly as for the research done by inner circle members inside Jays group.
@diegoc now, that's a valuable information, thank you for sharing. Do you use a half of a vial and leave another half for a week? I recall you do some blood tests, how were your kidneys the last 5 months, like creatinine, egfr, cystatine-c? How was the potassium? Any positive changes you noticed?
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I have tested mostly every Peptide or compound but i have not done FLGR, and plan to in January.
So you will not see give my opinion on a peptide i have not tested myself
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@diegoc I respect that position. Speculating, while entertaining, often results in necessity to defend a statement I am not very confident about, and I don't like doing it.
@vpeptides One of the biggest challenges in this space is that there is a lot of echo chamber info, where people from influencers and ‘experts’ to slobs on forums just regurgitate what they read somewhere, and a lot of times they might sound like they know what they’re talking about.
Part of what I love about this place is that there isn’t a lot of that nonsense.
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